King's College London

Research portal

Dr Thomas Iskratsch

  1. Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching

    Swiatlowska, P., Sit, B., Feng, Z., Marhuenda, E., Xanthis, I., Zingaro, S., Ward, M., Zhou, X., Xiao, Q., Shanahan, C., Jones, G. E., Yu, C-H. & Iskratsch, T., 15 Apr 2022, In: Science Advances. 8, 15, p. eabm3471 eabm3471.

    Research output: Contribution to journalArticlepeer-review

  2. Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861

    Pedrosa, A. R., Bodrug, N., Gomez-Escudero, J., Carter, E. P., Reynolds, L. E., Georgiou, P. N., Fernandez, I., Lees, D. M., Kostourou, V., Alexopoulou, A. N., Batista, S., Tavora, B., Serrels, B., Parsons, M., Iskratsch, T. & Hodivala-Dilke, K. M., 1 Sep 2019, In: Cancer Research. 79, 17, p. 4371-4386 16 p.

    Research output: Contribution to journalArticlepeer-review

  3. Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

    Pandey, P., Hawkes, W., Hu, J., Megone, W. V., Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. & Iskratsch, T., 5 Feb 2018, In: Developmental Cell. 44, 3, p. 326-336

    Research output: Contribution to journalArticlepeer-review

  4. Polymer fiber-based models of connective tissue repair and healing

    Lee, N. M., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W. N. & Lu, H. H., Jan 2017, In: Biomaterials. 112, p. 303-312 10 p.

    Research output: Contribution to journalArticlepeer-review

  5. α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions

    Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M. R., Iskratsch, T., Mathur, A., Ghassemi, S., Gauthier, N., Tabdanov, E., Lohner, J., Gondarenko, A., Chander, A. C., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M. P., 7 Nov 2016, In: Molecular biology of the cell. 27, 22, p. 3471-3479 9 p.

    Research output: Contribution to journalArticlepeer-review

  6. Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

    Santos, L. C., Blair, D. A., Kumari, S., Iskratsch, T., Cammer, M., Herbin, O., Alexandropoulos, K., Dustin, M. L. & Sheetz, M. P., 30 Jun 2016, (E-pub ahead of print) In: Immunology and Cell Biology.

    Research output: Contribution to journalArticlepeer-review

  7. Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

    Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M., Iskratsch, T., Ghassemi, S., Roca-Cusachs, P., O'Shaughnessy, B., Hone, J. & Sheetz, M., 1 Jan 2016, In: Nature Cell Biology. 18

    Research output: Contribution to journalArticlepeer-review

  8. Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

    Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M., Sheetz, M., Kam, L. & Iskratsch, T., 5 Oct 2015, In: Integrative Biology. 7, 10, p. 1272-1284 13 p.

    Research output: Contribution to journalArticlepeer-review

  9. Early events in cell spreading as a model for quantitative analysis of biomechanical events

    Wolfenson, H., Iskratsch, T. & Sheetz, M. P., 2 Dec 2014, In: Biophysical Journal. 107, 11, p. 2508-2514 7 p.

    Research output: Contribution to journalArticlepeer-review

  10. Appreciating force and shape—the rise of mechanotransduction in cell biology

    Iskratsch, T., Wolfenson, H. & Sheetz, M. P., Dec 2014, In: Nature reviews. Molecular cell biology. 15, 12, p. 825-833 9 p.

    Research output: Contribution to journalArticlepeer-review

  11. The formin FHOD1 in cardiomyocytes

    Dwyer, J., Pluess, M., Iskratsch, T., Dos Remedios, C. G. & Ehler, E., Sep 2014, In: Anatomical Record. 297, 9, p. 1560-1570 11 p.

    Research output: Contribution to journalArticlepeer-review

  12. N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

    Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P., 1 Apr 2014, In: Journal of cell science. 127, 7, p. 1394-1405 12 p.

    Research output: Contribution to journalArticlepeer-review

  13. FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration

    Iskratsch, T., Yu, C-H., Mathur, A., Liu, S., Stévenin, V., Dwyer, J., Hone, J., Ehler, E. & Sheetz, M., 9 Dec 2013, In: Developmental Cell. 27, 5, p. 545-559 15 p.

    Research output: Contribution to journalArticlepeer-review

  14. Two distinct phosphorylation events govern the function of muscle FHOD3

    Iskratsch, T., Reijntjes, S., Dwyer, J., Toselli, P., Dégano, I. R., Dominguez, I. & Ehler, E., Mar 2013, In: Cellular and Molecular Life Sciences. 70, 5, p. 893-908 16 p.

    Research output: Contribution to journalArticlepeer-review

  15. Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions

    Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. & Sheetz, M. P., Jan 2013, In: Molecular biology of the cell. 24, 1, p. 21-30 10 p.

    Research output: Contribution to journalArticlepeer-review

  16. Finding the weakest link: exploring integrin-mediated mechanical molecular pathways

    Roca-Cusachs, P., Iskratsch, T. & Sheetz, M. P., 28 Aug 2012, (E-pub ahead of print) In: Journal of cell science. 125, 13, p. 3025-3038 14 p.

    Research output: Contribution to journalArticlepeer-review

  17. Actin in striated muscle: recent insights into assembly and maintenance

    Dwyer, J., Iskratsch, T. & Ehler, E., Mar 2012, In: Biophysical Reviews. 4, 1, p. 17-25 9 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  18. Formin-g muscle cytoarchitecture

    Iskratsch, T. & Ehler, E., 15 Mar 2011, In: BioArchitecture. 1, 2, p. 66-68 3 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  19. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance

    Iskratsch, T., Lange, S., Dwyer, J., Kho, A. L., dos Remedios, C. & Ehler, E., 13 Dec 2010, In: The Journal of cell biology. 191, 6, p. 1159 - 1172 14 p.

    Research output: Contribution to journalArticlepeer-review

  20. Aberrant development of neuromuscular junctions in glycosylation-defective Large(myd) mice

    Herbst, R., Iskratsch, T., Unger, E. & Bittner, R. E., May 2009, In: Neuromuscular Disorders. 19, 5, p. 366-378 13 p.

    Research output: Contribution to journalArticlepeer-review

  21. Mammalian cells contain a second nucleocytoplasmic hexosaminidase

    Gutternigg, M., Rendić, D., Voglauer, R., Iskratsch, T. & Wilson, I. B. H., 1 Apr 2009, In: Biochemical Journal. 419, 1, p. 83-90 8 p.

    Research output: Contribution to journalArticlepeer-review

  22. Specificity analysis of lectins and antibodies using remodeled glycoproteins

    Iskratsch, T., Braun, A., Paschinger, K. & Wilson, I. B. H., 15 Mar 2009, In: Analytical Biochemistry. 386, 2, p. 133-146 14 p.

    Research output: Contribution to journalArticlepeer-review

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