Tibor Hortobagyi

Kovacs, G. G., Rozemuller, A. J. M., van Swieten, J. C., Gelpi, E., Majtenyi, K., Al-Sarraj, S., Troakes, C., Bodi, I., King, A., Hortobagyi, T., Esiri, M. M., Ansorge, O., Giaccone, G., Ferrer, I., Arzberger, T., Bogdanovic, N., Nilsson, T., Leisser, I., Alafuzoff, I., Ironside, J. W., & 2 othersKretzschmar, H. & Budka, H., Feb 2013, In: Neuropathology and Applied Neurobiology. 39, 2, p. 166-178 13 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion

Mitchell, J. C., McGoldrick, P., Vance, C., Hortobagyi, T., Sreedharan, J., Rogelj, B., Tudor, E. L., Smith, B. N., Klasen, C., Miller, C. C. J., Cooper, J. D., Greensmith, L. & Shaw, C. E., Feb 2013, In: Acta Neuropathologica. 125, 2, p. 273-288 16 p.

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

Smith, B. N., Newhouse, S., Shatunov, A., Vance, C., Topp, S., Johnson, L., Miller, J., Lee, Y., Troakes, C., Scott, K. M., Jones, A., Gray, I., Wright, J., Hortobágyi, T., Al-Sarraj, S., Rogelj, B., Powell, J., Lupton, M., Lovestone, S., Sapp, P. C., & 26 othersWeber, M., Nestor, P. J., Schelhaas, H. J., Asbroek, A. A. T., Silani, V., Gellera, C., Taroni, F., Ticozzi, N., Van den Berg, L., Veldink, J., Van Damme, P., Robberecht, W., Shaw, P. J., Kirby, J., Pall, H., Morrison, K. E., Morris, A., de Belleroche, J., Vianney de Jong, J. M. B., Baas, F., Andersen, P. M., Landers, J., Brown, R. H., Weale, M. E., Al-Chalabi, A. & Shaw, C. E., Jan 2013, In: European Journal of Human Genetics. 21, 1, p. 102-108 7 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

192 Citations (Scopus)

2012

An MND/ALS phenotype associated with C9orf72 repeat expansion: Abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline

Troakes, C., Maekawa, S., Wijesekera, L., Rogelj, B., Siklos, L., Bell, C., Smith, B., Newhouse, S., Vance, C., Johnson, L., Hortobagyi, T., Shatunov, A., Al-Chalabi, A., Leigh, N., Shaw, C. E., King, A. & Al-Sarraj, S., Oct 2012, In: Neuropathology. 32, 5, p. 505-514 10 p.

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Transportin 1 co-localisation with FUS inclusions is not characteristic for ALS-FUS confirming disrupted nuclear import of mutant FUS and distinguishing it from FTLD-FUS

Troakes, C., Hortobágyi, T., Vance, C., Al-Sarraj, S., Rogelj, B. & Shaw, C. E., 31 Aug 2012, In: Neuropathology and Applied Neurobiology. 39, 5, p. 553-561 9 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

2011

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

Tollervey, J. R., Wang, Z., Hortobagyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., Zupan, B., Rogelj, B., Shaw, C. E. & Ule, J., Oct 2011, In: Genome Research. 21, 10, p. 1572 - 1582 11 p.

Research output: Contribution to journal › Article › peer-review

186 Citations (Scopus)

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

Tollervey, J. R., Curk, T., Rogelj, B., Briese, M., Cereda, M., Kayikci, M., Koenig, J., Hortobagyi, T., Nishimura, A. L., Zupunski, V., Patani, R., Chandran, S., Rot, G., Zupan, B., Shaw, C. E. & Ule, J., Apr 2011, In: Nature Neuroscience. 14, 4, p. 452 - 458 7 p.

Research output: Contribution to journal › Article › peer-review

864 Citations (Scopus)

Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

Engmann, O., Hortobagyi, T., Thompson, A. J., Guadagno, J., Troakes, C., Soriano, S., Al-Sarraj, S., Kim, Y. & Giese, K. P., 15 Jul 2011, In: Biological psychiatry. 70, 2, p. 159 - 168 10 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Early and Presenting Symptoms of Dementia with Lewy Bodies

Auning, E., Rongve, A., Fladby, T., Booij, J., Hortobagyi, T., Siepel, F. J., Ballard, C. & Aarsland, D., Dec 2011, In: Dementia and Geriatric Cognitive Disorders. 32, 3, p. 202 - 208 7 p.

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

Mulder, J., Zilberter, M., Pasquare, S. J., Alpar, A., Schulte, G., Ferreira, S. G., Koefalvi, A., Martin-Moreno, A. M., Keimpema, E., Tanila, H., Watanabe, M., Mackie, K., Hortobagyi, T., de Ceballos, M. L. & Harkany, T., Apr 2011, In: Brain. 134, 4, p. 1041 - 1060 20 p.

Research output: Contribution to journal › Article › peer-review

170 Citations (Scopus)

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders

Hortobagyi, T., Troakes, C., Nishimura, A. L., Vance, C., van Swieten, J. C., Seelaar, H., King, A., Al-Sarraj, S., Rogelj, B. & Shaw, C. E., Apr 2011, In: Acta Neuropathologica. 121, 4, p. 519 - 527 9 p.

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

Al-Sarraj, S., King, A., Troakes, C., Smith, B., Maekawa, S., Bodi, I., Rogelj, B., Al-Chalabi, A., Hortobagyi, T. & Shaw, C. E., Dec 2011, In: Acta Neuropathologica. 122, 6, p. 691-702 12 p.

Research output: Contribution to journal › Article › peer-review

407 Citations (Scopus)

Research potential of archival fixed tissue: DNA preservation and immuno-reactivity

Troakes, C., Spandoni, V., Hortobagyi, T., Bodi, I., King, A. & Al-Sarraj, S., 2011, In: Neuropathology and Applied Neurobiology. 37, p. 31 - 32 2 p.

Research output: Contribution to journal › Meeting abstract

Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

Engmann, O., Hortobagyi, T., Pidsley, R., Troakes, C., Bernstein, H-G., Kreutz, M. R., Mill, J., Nikolic, M. & Giese, K. P., Aug 2011, In: Brain. 134, 8, p. 2408 - 2421 14 p.

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

The semi-quantitative assessment of subcortical small vessel disease pathology in elderly subjects: an initiative from the UK BD collaboration

Esiri, M., Attems, J., Bodi, I., Deramecourt, V., Hortobagyi, T., Joachim, C., Kalaria, R. N., King, A., Mann, D. M., Morris, J. H., Neal, J., Oulhaj, A. & Al-Sarraj, S., 2011, In: Neuropathology and Applied Neurobiology. 37, p. 12 - 13 2 p.

Research output: Contribution to journal › Meeting abstract

WNT Signaling in Activated Microglia Is Proinflammatory

Halleskog, C., Mulder, J., Dahlstrom, J., Mackie, K., Hortobagyi, T., Tanila, H., Puli, L. K., Faerber, K., Harkany, T. & Schulte, G., Jan 2011, In: Glia. 59, 1, p. 119 - 131 13 p.

Research output: Contribution to journal › Article › peer-review

175 Citations (Scopus)

2010

AMYOTROPHIC LATERAL SCLEROSIS MUTANT VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN-B TRANSGENIC MICE DEVELOP TAR-DNA-BINDING PROTEIN-43 PATHOLOGY

Tudor, E. L., Galtrey, C. M., Perkinton, M. S., Lau, K. -F., De Vos, K. J., Mitchell, J. C., Ackerley, S., Hortobagyi, T., Vamos, E., Leigh, P. N., Klasen, C., McLoughlin, D. M., Shaw, C. E. & Miller, C. C. J., May 2010, In: Neuroscience. 167, 3, p. 774 - 785 12 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Cytoplasmic TDP-43 accumulation is related to nuclear transport dysfunction in frontotemporal lobar degeneration and motor neuron disease

Hortobagyi, T., Nishimura, A. L., Troakes, C., Kathe, C., Fratta, P., Howell, M., Gallo, J-M., Shaw, C. E. & Rogelj, B., 2010, In: Brain Pathology. 20, p. 24 - 24 1 p.

Research output: Contribution to journal › Meeting abstract

Effects of cis-regulatory variation differ across regions of the adult human brain

Buonocore, F., Hill, M. J., Campbell, C. D., Oladimeji, P. B., Jeffries, A. R., Troakes, C., Hortobagyi, T., Williams, B. P., Cooper, J. D. & Bray, N. J., 15 Nov 2010, In: Human Molecular Genetics. 19, 22, p. 4490 - 4496 7 p., N/A.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Familial TDP proteinopathy with ALS presentation: characteristic clinical and pathological features

Troakes, C., Maekawa, S., Wijesekera, L., Rogelj, B., Smith, B., Vance, C., Hortobagyi, T., Arzberger, T., Kretzschmar, H., Leigh, N., Al-Chalabi, A., Shaw, C., King, A. & Al-Sarraj, S., 2010, In: Brain Pathology. 20, p. 33 - 33 1 p.

Research output: Contribution to journal › Meeting abstract

Levels of activators of cyclin-dependent protein kinase 5 (Cdk5) p25 and p35 in Alzheimer's disease

Engmann, O., Hortobagyi, T., Thompson, A. & Giese, K. P., 2010, In: European Neuropsychopharmacology. 20, p. S7 - S8

Research output: Contribution to journal › Meeting abstract

Meningeal granulomas in a patient with CVID

Dziadzio, M., Kidd, D., Hortobagyi, T. & Chee, R., 2010, In: Clinical and Experimental Immunology. 160, p. 15 - 15 1 p.

Research output: Contribution to journal › Meeting abstract

Mutant VAPB transgenic mice linked to amyotrophic lateral sclerosis type-8 develop TDP-43 pathology

Hortobagyi, T., Tudor, E. L., Galtrey, C., Perkinton, M. S., Lau, K-F., De Vos, K. V., Mitchel, J. C., Ackerley, S., Vamos, E., Leigh, P. N., Klasen, C., McLoughlin, D. M., Siklos, L., Shaw, C. E. & Miller, C. J., 2010, In: Brain Pathology. 20, p. 33 - 33 1 p.

Research output: Contribution to journal › Meeting abstract

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

Nishimura, A. L., Zupunski, V., Troakes, C., Kathe, C., Fratta, P., Howell, M., Gallo, J-M., Hortobagyi, T., Shaw, C. E. & Rogelj, B., 26 May 2010, In: Brain. 133, 6, p. 1763 - 1771 9 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

161 Citations (Scopus)

PATH46 Familial mutations in the RNA binding gene FUS result in cellular mislocalisation of the protein

Rogelj, B., Shaw, C. E., Vance, C. & Hortobagyi, T., 2010, In: Journal of Neurology, Neurosurgery and Psychiatry. 81, 11, p. E20 - E20

Research output: Contribution to journal › Meeting abstract

Role of Cdk5 activators in psychiatric diseases, learning and memory

Engmann, O., Hortobagyi, T., Bannerman, D., Thompson, A. J. & Giese, K. P., 2010, In: European Neuropsychopharmacology. 20, p. S171 1 p.

Research output: Contribution to journal › Meeting abstract

Vesicular glutamate transporter and cognition in stroke: A case-control autopsy study

Kirvell, S. L., Elliott, M. S., Kalaria, R. N., Hortobagyi, T., Ballard, C. G. & Francis, P. T., 16 Nov 2010, In: Neurology. 75, 20, p. 1803 - 1809 7 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

2009

Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

Alafuzoff, I., Thal, D. R., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., Gentleman, S., Giaccone, G., Graeber, M., Hortobagyi, T., Hoeftberger, R., Ince, P., Ironside, J. W., Kavantzas, N., King, A., Korkolopoulou, P., & 14 othersKovacs, G. G., Meyronet, D., Monoranu, C., Nilsson, T., Parchi, P., Patsouris, E., Pikkarainen, M., Revesz, T., Rozemuller, A., Seilhean, D., Schulz-Schaeffer, W., Streichenberger, N., Wharton, S. B. & Kretzschmar, H., 2009, In: Acta Neuropathologica. 117, 3, p. 309 - 320 12 p.

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Choline Acetyltransferase Activity in Vascular Dementia and Stroke

Sharp, S. I., Francis, P. T., Elliott, M. S. J., Kalaria, R. N., Bajic, N., Hortobagyi, T. & Ballard, C. G., Oct 2009, In: Dementia and Geriatric Cognitive Disorders. 28, 3, p. 233 - 238 6 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Cysticercosis of the Fourth Ventricle Causing Sudden Death: A Case Report and Review of the Literature

Hortobagyi, T., Alhakim, A., Biedrzycki, O., Djurovic, V., Rawal, J. & Al-Sarraj, S., Mar 2009, In: PATHOLOGY ONCOLOGY RESEARCH. 15, 1, p. 143 - 146 4 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Giant Cell Tumour and Central Giant Cell Reparative Granuloma of the Skull: do These Represent Ends of a Spectrum? A Case Report and Literature Review

Saw, S., Thomas, N., Gleeson, M. J., Bodi, I., Connor, S. & Hortobagyi, T., Jun 2009, In: PATHOLOGY ONCOLOGY RESEARCH. 15, 2, p. 291 - 295 5 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition

Elliott, M. S. J., Ballard, C. G., Kalaria, R. N., Perry, R., Hortobagyi, T. & Francis, P. T., Jul 2009, In: Brain. 132, 7, p. 1858 - 1865 8 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

Vance, C., Rogelj, B., Hortobágyi, T., De Vos, K. J., Nishimura, A. L., Sreedharan, J., Hu, X., Smith, B., Ruddy, D., Wright, P., Ganesalingam, J., Williams, K. L., Tripathi, V., Al-Saraj, S., Al-Chalabi, A., Leigh, P. N., Blair, I. P., Nicholson, G., de Belleroche, J., Gallo, J-M., & 2 othersMiller, C. C. & Shaw, C. E., 27 Feb 2009, In: Science. 323, 5918, p. 1208-11 4 p.

Research output: Contribution to journal › Article › peer-review

2139 Citations (Scopus)

Mutations in RNA processing protein FUS result in neurodegeneration with cytoplasmic inclusion and cause familial amyotrophic lateral sclerosis

Hortobagyi, T., Vance, C., Rogelj, B., de Vos, K., Troakes, C., Al-Sarraj, S. & Shaw, C., 2009, In: Acta Neuropathologica. 118, 3, p. 445-445 1 p.

Research output: Contribution to journal › Meeting abstract

Reproducibility in the assessment of Alzheimer's disease and Lewy body disease-related pathologies: a study by Brain Net Europe

Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bodi, I., Bogdanovic, N., Budka, H., Bugiani, O., Boluda, S., Duyckaerts, C., Ferrer, I., Gelpi, E., Gentleman, S., Giaccone, G., Graeber, M. B., Holton, J. L., Hortobagyi, T., Hoeftberger, R., Ince, P., Kamphorst, W., Ironside, J. W., & 23 othersKavantzas, N., King, A., Korkolopoulou, P., Kovacs, G. G., Larionov, S. S., Meyronet, D., Monoranu, C., Nilsson, T., Parchi, P., Parkkinen, L., Patsouris, E., Pikkarainen, M., Roggendorf, W., Seilhean, D., Schulz-Schaeffer, W., Revesz, T., Rozemuller, A., Stadelmann-Nessler, C., Streichenberger, N., Tagliavini, F., Thal, D. R., Wharton, S. B. & Kretzschmar, H., 2009, In: Neuropathology and Applied Neurobiology. 35, p. 12 - 13 2 p.

Research output: Contribution to journal › Meeting abstract

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations

Maekawa, S., Leigh, P. N., King, A., Jones, E., Steele, J. C., Bodi, I., Shaw, C. E., Hortobagyi, T. & Al-Sarraj, S., Dec 2009, In: Neuropathology. 29, 6, p. 672 - 683 12 p.

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

Currais, A., Hortobagyi, T. & Soriano, S., 2009, In: Aging. 1, 4, p. 363 - 371 9 p.

Research output: Contribution to journal › Literature review › peer-review

84 Citations (Scopus)

2008

71-year-old man with multiple metastases to the brain

Hortobagyi, T., Thomas, N. W. & King, A., Feb 2008, In: Neuropathology. 28, 1, p. 103 - 105 3 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Desmoplastic ganglioglioma with meningiomatous and myofibroblastic components presenting with epilepsy

Hortobagyi, T., Honavar, M., Selway, R. & Al-Sarraj, S., Feb 2008, In: Neuropathology and Applied Neurobiology. 34, 1, p. 118 - 123 6 p.

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Familial distal myopathy with complex pathologies

McGuone, D., Barnes, P., Bannister, P. & Hortobagyi, T., 2008, In: Neuropathology and Applied Neurobiology. 34, p. 34 - 35 2 p.

Research output: Contribution to journal › Meeting abstract

Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia

Mulugeta, E., Molina-Holgado, F., Elliott, M. S., Hortobagyi, T., Perry, R., Kalaria, R. N., Ballard, C. G. & Francis, P. T., Mar 2008, In: Dementia and Geriatric Cognitive Disorders. 25, 3, p. 278 - 286 9 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain

Malik, B., Currais, A., Andres, A., Towlson, C., Pitsi, D., Nunes, A., Niblock, M., Cooper, J., Hortobagyi, T. & Soriano, S., 2008, In: CELL CYCLE. 7, 5, p. 637 - 646 10 p.

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Pontocerebellar Hypoplasia Type 1

Szabo, N., Szabo, H., Hortobagyi, T., Turi, S. & Sztriha, L., Oct 2008, In: Pediatric Neurology. 39, 4, p. 286 - 288 3 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

TDP-43 consistently co-localised with ubiquitinated inclusions in sporadic amyotrophic lateral sclerosis but occasionally in familial amyotrophic lateral sclerosis with and without SOD1 mutation

Al-Sarraj, S., Makaewa, S., King, A., Bodi, I., Hortobagyi, T., Shaw, C. & Leigh, N., 2008, In: Neuropathology and Applied Neurobiology. 34, p. 12 - 12 1 p.

Research output: Contribution to journal › Meeting abstract

THE NEURONAL CELL CYCLE AS A MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

Currais, A., Malik, B., Hortobagyi, T. & Soriano, S., 2008, In: Zdravniski Vestnik-Slovenian Medical Journal. 77, p. II13 - II20

Research output: Contribution to journal › Article › peer-review

Tibor Hortobagyi

Research output

Search results