Tim Hubbard

Tim Hubbard


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Personal profile

Biographical details

I studied Biochemistry at University of Cambridge, followed by a PhD in Protein Design at the Department of Crystallography,‭ ‬Birkbeck College,‭ University of ‬London. Following a postdoctoral fellowship at the Protein Engineering Research Institute in Osaka under the EU scientific training program in Japan‭ I returned to Cambridge in 1990 as a Zeneca Fellow at the MRC‭‭ ‬Centre for Protein Engineering to work on protein folding, ‬classification and design. I co-founded SCOP‭ (‬the Structural Classification of Proteins database‭)‬ and developed algorithms to make protein structure predictions and assess their accuracy and to calibrate the reliability of sequence alignment methods.‭ ‬I was one of the most successful participants in the first CASP‭ (‬Critical Assessment of Structure Prediction‭) ‬competition in‭ ‬1994‭ ‬and a co-organiser of subsequent CASP competitions‭ (‬CASP2-CASP7‭) ‬until‭ ‬2007. In‭ ‬1997‭ ‬I joined the Wellcome Trust Sanger Institute to become Head of Human Genome Analysis, where I was one of the organisers of the sequencing of the human genome. In 1999 I co-founded the Ensembl project to analysis, organise and provide access to the human genome. From 2007 I led the GENCODE project to annotate the structure of all human genes, initially as part of the ENCODE project. I‭ was the Sanger Institute PI of the Genome Reference Consortium,‭ ‬which is responsible for reference genome sequences of human,‭ ‬mouse and zebrafish. I become Head of the Informatics division from‭ ‬2007. After the announcement of the 100,000 genomes project 2012 ‬I was seconded part time as specialist advisor for genomics to NHS England leading up to the creation of Genomics England. In October 2013 I was appointed Professor of Bioinformatics and Head of the Department of Medical & Molecular Genetics at King's College London and Director of Bioinformatics for King's Health Partners with a part time secondment as Head of Genome Analysis at Genomics England. In 2018 I was also appointed Associate Director (King's) for the Health Data Research UK (HDRUK) London Site.

Research interests (short)

Genomics & Bioinformatics, particularly around gene and regulatory annotation and predictive modelling; Human phenotype data, particularly around clinical data capture, organisation and research access; Genome Medicine, particularly the mainstreaming of whole genome sequencing into health systems for rare disease and cancer diagnostics, as well as enabling real time decision support for personalisation of treatment.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, The Design, Expression and Characterisation of a Novel Protein, Birkbeck, University of London

Award Date: 1 Jan 1988

Bachelor of Arts, Natural Sciences (Biochemistry), University of Cambridge

Award Date: 1 Jan 1985

External positions

Head of Genome Analysis, Genomics England Ltd.

1 Oct 2013 → …


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