King's College London

Research portal

Professor Timothy Vyse

  1. Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

    Wang, Y. F., Zhang, Y., Lin, Z., Zhang, H., Wang, T. Y., Cao, Y., Morris, D. L., Sheng, Y., Yin, X., Zhong, S. L., Gu, X., Lei, Y., He, J., Wu, Q., Shen, J. J., Yang, J., Lam, T. H., Lin, J. H., Mai, Z. M., Guo, M. & 15 others, Tang, Y., Chen, Y., Song, Q., Ban, B., Mok, C. C., Cui, Y., Lu, L., Shen, N., Sham, P. C., Lau, C. S., Smith, D. K., Vyse, T. J., Zhang, X., Lau, Y. L. & Yang, W., Dec 2021, In: Nature Communications. 12, 1, 772.

    Research output: Contribution to journalArticlepeer-review

  2. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

    Ortiz-Fernández, L., Saruhan-Direskeneli, G., Alibaz-Oner, F., Kaymaz-Tahra, S., Coit, P., Kong, X., Kiprianos, A. P., Maughan, R. T., Aydin, S. Z., Aksu, K., Keser, G., Kamali, S., Inanc, M., Springer, J., Akar, S., Onen, F., Akkoc, N., Khalidi, N. A., Koening, C., Karadag, O. & 51 others, Kiraz, S., Forbess, L., Langford, C. A., McAlear, C. A., Ozbalkan, Z., Yavuz, S., Çetin, G. Y., Alpay-Kanitez, N., Chung, S., Ates, A., Karaaslan, Y., McKinnon-Maksimowicz, K., Monach, P. A., Ozer, H. T. E., Seyahi, E., Fresko, I., Cefle, A., Seo, P., Warrington, K. J., Ozturk, M. A., Ytterberg, S. R., Cobankara, V., Onat, A. M., Duzgun, N., Bıcakcıgil, M., Yentür, S. P., Lally, L., Manfredi, A. A., Baldissera, E., Erken, E., Yazici, A., Kısacık, B., Kaşifoğlu, T., Dalkilic, E., Cuthbertson, D., Pagnoux, C., Sreih, A., Reales, G., Wallace, C., Wren, J. D., Cunninghame-Graham, D. S., Vyse, T. J., Sun, Y., Chen, H., Grayson, P. C., Tombetti, E., Jiang, L., Mason, J. C., Merkel, P. A., Direskeneli, H. & Sawalha, A. H., 7 Jan 2021, In: American Journal of Human Genetics. 108, 1, p. 84-99 16 p.

    Research output: Contribution to journalArticlepeer-review

  3. Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

    Gajdasik, D. W., Gaspal, F., Halford, E. E., Fiancette, R., Dutton, E. E., Willis, C., Rückert, T., Romagnani, C., Gerard, A., Bevington, S. L., MacDonald, A. S., Botto, M., Vyse, T. & Withers, D. R., 1 Dec 2020, In: Nature Communications. 11, 1, 3421.

    Research output: Contribution to journalArticlepeer-review

  4. Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus

    Zhang, F., Wang, Y. F., Zhang, Y., Lin, Z., Cao, Y., Zhang, H., Liu, Z. Y., Morris, D. L., Sheng, Y., Cui, Y., Zhang, X., Vyse, T. J., Lau, Y. L., Yang, W. & Chen, Y., 3 Jul 2020, In: Frontiers in Genetics. 11, 600.

    Research output: Contribution to journalArticlepeer-review

  5. Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity

    Chen, L., Wang, Y. F., Liu, L., Bielowka, A., Ahmed, R., Zhang, H., Tombleson, P., Roberts, A. L., Odhams, C. A., Cunninghame Graham, D. S., Zhang, X., Yang, W., Vyse, T. J. & Morris, D. L., 27 Jun 2020, In: Human Molecular Genetics. 29, 10, p. 1745-1756 12 p., ddaa030.

    Research output: Contribution to journalArticlepeer-review

  6. Complement genes contribute sex-biased vulnerability in diverse disorders

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, Kamitaki, N., Sekar, A., Handsaker, R. E., de Rivera, H., Tooley, K., Morris, D. L., Taylor, K. E., Whelan, C. W., Tombleson, P., Loohuis, L. M. O., Boehnke, M., Kimberly, R. P., Kaufman, K. M., Harley, J. B., Langefeld, C. D., Seidman, C. E., Pato, M. T., Pato, C. N., Ophoff, R. A. & 4 others, Graham, R. R., Criswell, L. A., Vyse, T. J. & McCarroll, S. A., 1 Jun 2020, In: Nature. 582, 7813, p. 577-581 5 p.

    Research output: Contribution to journalArticlepeer-review

  7. GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

    European Scleroderma Group† & Australian Scleroderma Interest Group (ASIG), 1 Dec 2019, In: Nature Communications. 10, 1, 4955.

    Research output: Contribution to journalArticlepeer-review

  8. Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression

    Ferreira, R. C., Castro Dopico, X., Oliveira, J. J., Rainbow, D. B., Yang, J. H., Trzupek, D., Todd, S. A., McNeill, M., Steri, M., Orrù, V., Fiorillo, E., Crouch, D. J. M., Pekalski, M. L., Cucca, F., Tree, T. I., Vyse, T. J., Wicker, L. S. & Todd, J. A., 8 Nov 2019, In: Frontiers in Immunology. 10, 2606.

    Research output: Contribution to journalArticlepeer-review

  9. Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

    Din, L., Sheikh, M., Kosaraju, N., Smedby, K. E., Bernatsky, S., Berndt, S. I., Skibola, C. F., Nieters, A., Wang, S., McKay, J. D., Cocco, P., Maynadié, M., Foretová, L., Staines, A., Mack, T. M., de Sanjosé, S., Vyse, T. J., Padyukov, L., Monnereau, A., Arslan, A. A. & 72 others, Moore, A., Brooks-Wilson, A. R., Novak, A. J., Glimelius, B., Birmann, B. M., Link, B. K., Stewart, C., Vajdic, C. M., Haioun, C., Magnani, C., Conti, D. V., Cox, D. G., Casabonne, D., Albanes, D., Kane, E., Roman, E., Muzi, G., Salles, G., Giles, G. G., Adami, H. O., Ghesquières, H., De Vivo, I., Clavel, J., Cerhan, J. R., Spinelli, J. J., Hofmann, J., Vijai, J., Curtin, K., Costenbader, K. H., Onel, K., Offit, K., Teras, L. R., Morton, L., Conde, L., Miligi, L., Melbye, M., Ennas, M. G., Liebow, M., Purdue, M. P., Glenn, M., Southey, M. C., Din, M., Rothman, N., Camp, N. J., Wong Doo, N., Becker, N., Pradhan, N., Bracci, P. M., Boffetta, P., Vineis, P., Brennan, P., Kraft, P., Lan, Q., Severson, R. K., Vermeulen, R. C. H., Milne, R. L., Kaaks, R., Travis, R. C., Weinstein, S. J., Chanock, S. J., Ansell, S. M., Slager, S. L., Zheng, T., Zhang, Y., Benavente, Y., Taub, Z., Madireddy, L., Gourraud, P. A., Oksenberg, J. R., Cozen, W., Hjalgrim, H. & Khankhanian, P., 1 Oct 2019, In: Genetic Epidemiology. 43, 7, p. 844-863 20 p.

    Research output: Contribution to journalArticlepeer-review

  10. Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

    Odhams, C. A., Roberts, A. L., Vester, S. K., S T Duarte, C., Beales, C. T., Clarke, A. J., Lindinger, S., Daffern, S. J., Zito, A., Chen, L., Jones, L. L., Boteva, L., Morris, D. L., Small, K. S., Fernando, M. M. A., Cunninghame Graham, D. S. & Vyse, T. J., 31 May 2019, In: Nature Communications. 10, p. 1-15 2164.

    Research output: Contribution to journalArticlepeer-review

  11. High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

    Reid, S., Alexsson, A., Frodlund, M., Morris, D., Sandling, J. K., Bolin, K., Svenungsson, E., Jönsen, A., Bengtsson, C., Gunnarsson, I., Illescas Rodriguez, V., Bengtsson, A., Arve, S., Rantapää-Dahlqvist, S., Eloranta, M. L., Syvänen, A. C., Sjöwall, C., Vyse, T. J., Rönnblom, L. & Leonard, D., 1 Jan 2019, In: Annals of the rheumatic diseases.

    Research output: Contribution to journalArticlepeer-review

  12. Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases

    Acosta-Herrera, M., Kerick, M., González-Serna, D., Wijmenga, C., Franke, A., Gregersen, P. K., Padyukov, L., Worthington, J., Vyse, T. J., Alarcón-Riquelme, M. E., Mayes, M. D. & Martin, J., 2019, In: Annals of the rheumatic diseases. 78, 3, p. 311-319 9 p.

    Research output: Contribution to journalArticlepeer-review

  13. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans

    Hanscombe, K. B., Morris, D. L., Noble, J. A., Dilthey, A. T., Tombleson, P., Kaufman, K. M., Comeau, M., Langefeld, C. D., Alarcon-Riquelme, M. E., Gaffney, P. M., Jacob, C. O., Sivils, K. L., Tsao, B. P., Alarcon, G. S., Brown, E. E., Croker, J., Edberg, J., Gilkeson, G., James, J. A., Kamen, D. L. & 16 others, Kelly, J. A., McCune, J., Merrill, J. T., Petri, M., Ramsey-Goldman, R., Reveille, J. D., Salmon, J. E., Scofield, H., Utset, T., Wallace, D. J., Weisman, M. H., Kimberly, R. P., Harley, J. B., Lewis, C. M., Criswell, L. A. & Vyse, T. J., 1 Nov 2018, In: Human Molecular Genetics. 27, 21, p. 3813-3824 12 p., 27(21).

    Research output: Contribution to journalArticlepeer-review

  14. A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

    Patel, Z. H., Lu, X., Miller, D., Forney, C. R., Lee, J., Lynch, A., Schroeder, C., Parks, L., Magnusen, A. F., Chen, X., Pujato, M., Maddox, A., Zoller, E. E., Namjou, B., Brunner, H. I., Henrickson, M., Huggins, J. L., Williams, A. H., Ziegler, J. T., Comeau, M. E. & 49 others, Marion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S. K., Stevens, A. M., Freedman, B. I., Pons-Estel, B. A., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S., Alarcón, G. S., Martin, J., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L., Criswell, L. A., Vilá, L. M., Petri, M., Scofield, R. H., Kimberly, R. P., Edberg, J. C., Ramsey-Goldman, R., Bang, S. Y., Lee, H. S., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Merrill, J. T., Niewold, T. B., Ainsworth, H. C., Silverman, E. D., Weisman, M. H., Wallace, D. J., Raj, P., Guthridge, J. M., Gaffney, P. M., Kelly, J. A., Alarcón-Riquelme, M. E., Langefeld, C. D., Wakeland, E. K., Kaufman, K. M., Weirauch, M. T., Harley, J. B. & Kottyan, L. C., 1 Jul 2018, In: Human Molecular Genetics. 27, 13, p. 2392-2404 13 p.

    Research output: Contribution to journalArticlepeer-review

  15. Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

    Halim, T. Y. F., Rana, B. M. J., Walker, J. A., Kerscher, B., Knolle, M. D., Jolin, H. E., Serrao, E. M., Haim-Vilmovsky, L., Teichmann, S. A., Rodewald, H-R., Botto, M., Vyse, T. J., Fallon, P. G., Li, Z., Withers, D. R. & McKenzie, A. N. J., 12 Jun 2018, In: Immunity.

    Research output: Contribution to journalArticlepeer-review

  16. Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE

    Zhang, H., Zhang, Y., Wang, Y. F., Morris, D., Hirankarn, N., Sheng, Y., Shen, J., Pan, H. F., Yang, J., Yang, S., Cui, Y., Ye, D. Q., Vyse, T. J., Zhang, X., Lau, Y. L. & Yang, W., 3 May 2018, In: Arthritis Research and Therapy. 20, 1, 92.

    Research output: Contribution to journalArticlepeer-review

  17. Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning

    Wang, Y-F., Zhang, Y., Zhu, Z., Wang, T-Y., Morris, D. L., Shen, J. J., Zhang, H., Pan, H-F., Yang, J., Yang, S., Ye, D-Q., Vyse, T. J., Cui, Y., Zhang, X., Sheng, Y., Lau, Y. L. & Yang, W., 6 Apr 2018, In: Annals of the rheumatic diseases. 77, 7, p. 1078-1084 7 p.

    Research output: Contribution to journalArticlepeer-review

  18. Autoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus

    Lewis, M. J., McAndrew, M. B., Wheeler, C., Workman, N., Agashe, P., Koopmann, J., Uddin, E., Morris, D. L., Zou, L., Stark, R., Anson, J., Cope, A. P. & Vyse, T. J., 22 Mar 2018, In: Journal of Autoimmunity.

    Research output: Contribution to journalArticlepeer-review

  19. De novo mutations implicate novel genes in systemic lupus erythematosus

    Pullabhatla, V., Roberts, A. L., Lewis, M. J., Mauro, D., Morris, D. L., Odhams, C. A., Tombleson, P., Liljedahl, U., Vyse, S., Simpson, M. A., Sauer, S., de Rinaldis, E., Syvänen, A. C. & Vyse, T. J., 1 Feb 2018, In: Human Molecular Genetics. 27, 3, p. 421-429 9 p.

    Research output: Contribution to journalArticlepeer-review

  20. B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis

    Cortini, A., Ellinghaus, U., Malik, T. H., Cunninghame Graham, D. S., Botto, M. & Vyse, T. J., 1 Dec 2017, In: Annals of the rheumatic diseases. 76, 12, p. 2095-2103 9 p.

    Research output: Contribution to journalArticlepeer-review

  21. Genetic advances in systemic lupus erythematosus: an update

    Chen, L., Morris, D. L. & Vyse, T. J., Sep 2017, In: Current Opinion in Rheumatology. 29, 5, p. 423-433 11 p.

    Research output: Contribution to journalArticlepeer-review

  22. Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

    Ferreira, R. C., Simons, H. Z., Thompson, W. S., Rainbow, D. B., Yang, X., Cutler, A. J., Oliveira, J., Castro Dopico, X., Smyth, D. J., Savinykh, N., Mashar, M., Vyse, T. J., Dunger, D. B., Baxendale, H., Chandra, A., Wallace, C., Todd, J. A., Wicker, L. S. & Pekalski, M. L., 23 Jul 2017, In: Journal of Autoimmunity.

    Research output: Contribution to journalArticlepeer-review

  23. Transancestral mapping and genetic load in systemic lupus erythematosus

    Langefeld, C. D., Ainsworth, H. C., Graham, D. S. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Acevedo-vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bijl, M., Brown, E. E. & 88 others, Brunner, H. I., Cardiel, M. H., Catoggio, L., Cervera, R., Cucho-venegas, J. M., Dahlqvist, S. R., D’alfonso, S., Da Silva, B. M., De La Rúa Figueroa, I., Doria, A., Edberg, J. C., Endreffy, E., Esquivel-valerio, J. A., Fortin, P. R., Freedman, B. I., Frostegård, J., García, M. A., De La Torre, I. G., Gilkeson, G. S., Gladman, D. D., Gunnarsson, I., Guthridge, J. M., Huggins, J. L., James, J. A., Kallenberg, C. G. M., Kamen, D. L., Karp, D. R., Kaufman, K. M., Kottyan, L. C., Kovács, L., Laustrup, H., Lauwerys, B. R., Li, Q., Maradiaga-ceceña, M. A., Martín, J., Mccune, J. M., Mcwilliams, D. R., Merrill, J. T., Miranda, P., Moctezuma, J. F., Nath, S. K., Niewold, T. B., Orozco, L., Ortego-centeno, N., Petri, M., Pineau, C. A., Pons-estel, B. A., Pope, J., Raj, P., Ramsey-goldman, R., Reveille, J. D., Russell, L. P., Sabio, J. M., Aguilar-salinas, C. A., Scherbarth, H. R., Scorza, R., Seldin, M. F., Sjöwall, C., Svenungsson, E., Thompson, S. D., Toloza, S. M. A., Truedsson, L., Tusié-luna, T., Vasconcelos, C., Vilá, L. M., Wallace, D. J., Weisman, M. H., Wither, J. E., Bhangale, T., Oksenberg, J. R., Rioux, J. D., Gregersen, P. K., Syvänen, A., Rönnblom, L., Criswell, L. A., Jacob, C. O., Sivils, K. L., Tsao, B. P., Schanberg, L. E., Behrens, T. W., Silverman, E. D., Alarcón-riquelme, M. E., Kimberly, R. P., Harley, J. B., Wakeland, E. K., Graham, R. R., Gaffney, P. M. & Vyse, T. J., 17 Jul 2017, In: Nature Communications. 8, 1, 18 p., 16021.

    Research output: Contribution to journalArticlepeer-review

  24. Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus

    Ellinghaus, U., Cortini, A., Pinder, C. L., Le Friec, G., Kemper, C. & Vyse, T. J., Jul 2017, In: European Journal of Immunology. 47, 7, p. 1200-1210

    Research output: Contribution to journalArticlepeer-review

  25. Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons

    Li, H., Reksten, T. R., Ice, J. A., Kelly, J. A., Adrianto, I., Rasmussen, A., Wang, S., He, B., Grundahl, K. M., Glenn, S. B., Miceli-Richard, C., Bowman, S., Lester, S., Eriksson, P., Eloranta, M. L., Brun, J. G., Gøransson, L. G., Harboe, E., Guthridge, J. M., Kaufman, K. M. & 44 others, Kvarnström, M., Cunninghame Graham, D. S., Patel, K., Adler, A. J., Farris, A. D., Brennan, M. T., Chodosh, J., Gopalakrishnan, R., Weisman, M. H., Venuturupalli, S., Wallace, D. J., Hefner, K. S., Houston, G. D., Huang, A. J. W., Hughes, P. J., Lewis, D. M., Radfar, L., Vista, E. S., Edgar, C. E., Rohrer, M. D., Stone, D. U., Vyse, T. J., Harley, J. B., Gaffney, P. M., James, J. A., Turner, S., Alevizos, I., Anaya, J. M., Rhodus, N. L., Segal, B. M., Montgomery, C. G., Scofield, R. H., Kovats, S., Mariette, X., Rönnblom, L., Witte, T., Rischmueller, M., Wahren-Herlenius, M., Omdal, R., Jonsson, R., Ng, W. F., Nordmark, G., Lessard, C. J. & Sivils, K. L., 22 Jun 2017, In: PL o S Genetics. 13, 6, e1006820.

    Research output: Contribution to journalArticlepeer-review

  26. Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus

    Yesim Demirci, F., Wang, X., Morris, D. L., Feingold, E., Bernatsky, S., Pineau, C., Clarke, A., Ramsey-Goldman, R., Manzi, S., Vyse, T. J. & Ilyas Kamboh, M., 1 Jun 2017, In: Journal of Medical Genetics. 54, 6, p. 381-389 9 p.

    Research output: Contribution to journalArticlepeer-review

  27. Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression

    Hauberg, M. E., Zhang, W., Giambartolomei, C., Franzén, O., Morris, D. L., Vyse, T. J., Ruusalepp, A., Fromer, M., Sieberts, S. K., Johnson, J. S., Ruderfer, D. M., Shah, H. R., Klei, L. L., Dang, K. K., Perumal, T. M., Logsdon, B. A., Mahajan, M. C., Mangravite, L. M., Essioux, L., Toyoshiba, H. & 14 others, Gur, R. E., Hahn, C-G., Lewis, D. A., Haroutunian, V., Peters, M. A., Lipska, B. K., Buxbaum, J. D., Hirai, K., Domenici, E., Devlin, B., Sklar, P., Schadt, E. E., Björkegren, J. L. M. & Roussos, P., 25 May 2017, In: American Journal of Human Genetics. 100, 6, p. 885–894

    Research output: Contribution to journalArticlepeer-review

  28. A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

    Carmona, F. D., Vaglio, A., Mackie, S. L., Hernández-Rodríguez, J., Monach, P. A., Castañeda, S., Solans, R., Morado, I. C., Narváez, J., Ramentol-Sintas, M., Pease, C. T., Dasgupta, B., Watts, R., Khalidi, N., Langford, C. A., Ytterberg, S., Boiardi, L., Beretta, L., Govoni, M., Emmi, G. & 116 others, Bonatti, F., Cimmino, M. A., Witte, T., Neumann, T., Holle, J., Schönau, V., Sailler, L., Papo, T., Haroche, J., Mahr, A., Mouthon, L., Molberg, Ø., Diamantopoulos, A. P., Voskuyl, A., Brouwer, E., Daikeler, T., Berger, C. T., Molloy, E. S., O'Neill, L., Blockmans, D., Lie, B. A., Mclaren, P., Vyse, T. J., Wijmenga, C., Allanore, Y., Koeleman, B. P. C., Callejas, J. L., Caminal-Montero, L., Corbera-Bellalta, M., de Miguel, E., López, J. B. D., García-Villanueva, M. J., Gómez-Vaquero, C., Guijarro-Rojas, M., Hidalgo-Conde, A., Marí-Alfonso, B., Berriochoa, A. M., Zapico, A. M., Martínez-Taboada, V. M., Miranda-Filloy, J. A., Monfort, J., Ortego-Centeno, N., Pérez-Conesa, M., Prieto-González, S., Raya, E., Fernández, R. R., Sánchez-Martín, J., Sopeña, B., Tío, L., Unzurrunzaga, A., Gough, A., Isaacs, J. D., Green, M., McHugh, N., Hordon, L., Kamath, S., Nisar, M., Patel, Y., Yee, C. S., Stevens, R., Nandi, P., Nandagudi, A., Jarrett, S., Li, C., Levy, S., Mollan, S., Salih, A., Wordsworth, O., Sanders, E., Roads, E., Gill, A., Carr, L., Routledge, C., Culfear, K., Nugaliyadde, A., James, L., Spimpolo, J., Kempa, A., Mackenzie, F., Fong, R., Peters, G., Rowbotham, B., Masqood, Z., Hollywood, J., Gondo, P., Wood, R., Martin, S., Rashid, L. H., Robinson, J. I., Morgan, M., Sorensen, L., Taylor, J., Carette, S., Chung, S., Cuthbertson, D., Forbess, L. J., Gewurz-Singer, O., Hoffman, G. S., Koening, C. L., Maksimowicz-McKinnon, K. M., McAlear, C. A., Moreland, L. W., Pagnoux, C., Seo, P., Specks, U., Spiera, R. F., Sreih, A., Warrington, K. J., Weisman, M., Barrett, J. H., Cid, M. C., Salvarani, C., Merkel, P. A., Morgan, A. W., González-Gay, M. A. & Martín, J., 5 Jan 2017, In: American Journal of Human Genetics. 100, 1, p. 64-74 11 p.

    Research output: Contribution to journalArticlepeer-review

  29. Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

    Burn, G. L., Cornish, G. H., Potrzebowska, K., Samuelsson, M., Griffié, J., Minoughan, S., Yates, M., Ashdown, G., Pernodet, N., Morrison, V. L., Sanchez-Blanco, C., Purvis, H., Clarke, F., Brownlie, R. J., Vyse, T. J., Zamoyska, R., Owen, D. M., Svensson, L. M. & Cope, A. P., 4 Oct 2016, In: Science Signaling. 9, 448, ra99.

    Research output: Contribution to journalArticlepeer-review

  30. The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling

    Roberts, A. L., Fürnrohr, B. G., Vyse, T. J. & Rhodes, B., 1 Sep 2016, In: Clinical and Experimental Immunology. 185, 3, p. 361-371 11 p.

    Research output: Contribution to journalArticlepeer-review

  31. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

    Morris, D. L., Sheng, Y., Zhang, Y., Wang, Y. F., Zhu, Z., Tombleson, P., Chen, L., Cunninghame Graham, D. S., Bentham, J., Roberts, A. L., Chen, R., Zuo, X., Wang, T., Wen, L., Yang, C., Liu, L., Yang, L., Li, F., Huang, Y., Yin, X. & 12 others, Yang, S., Rönnblom, L., Fürnrohr, B. G., Voll, R. E., Schett, G., Costedoat–Chalumeau, N., Gaffney, P. M., Lau, Y. L., Zhang, X., Yang, W., Cui, Y. & Vyse, T. J., 1 Aug 2016, In: Nature Genetics. 48, 8, p. 940–946

    Research output: Contribution to journalArticlepeer-review

  32. A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus

    Márquez, A., Vidal-Bralo, L., Rodríguez-Rodríguez, L., González-Gay, M. A., Balsa, A., González-álvaro, I., Carreira, P., Ortego-Centeno, N., Ayala-Gutiérrez, M. M., García-Hernández, F. J., González-Escribano, M. F., Sabio, J. M., Tolosa, C., Suárez, A., González, A., Padyukov, L., Worthington, J., Vyse, T., Alarcón-Riquelme, M. E. & Martín, J., 18 May 2016, In: Annals of the Rheumatic Diseases.

    Research output: Contribution to journalArticlepeer-review

  33. Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans

    Lessard, C. J., Sajuthi, S., Zhao, J., Kim, K., Ice, J. A., Li, H., Ainsworth, H., Rasmussen, A., Kelly, J. A., Marion, M., Bang, S. Y., Bin Joo, Y., Choi, J., Lee, H. S., Mo Kang, Y., Suh, C. H., Tae Chung, W., Lee, S. K., Choe, J. Y., Cheol Shim, S. & 19 others, Hee Oh, J., Jin Kim, Y., Han, B. G., Shen, N., Siew Howe, H., Wakeland, E. K., Li, Q. Z., Wook Song, Y., Gaffney, P. M., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Vyse, T. J., Harley, J. B., Sivils, K. L., Bae, S. C., Langefeld, C. D. & Tsao, B. P., 1 May 2016, In: Arthritis and Rheumatology. 68, 5, p. 1197-1209 13 p.

    Research output: Contribution to journalArticlepeer-review

  34. X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

    Liu, K., Kurien, B. T., Zimmerman, S. L., Kaufman, K. M., Taft, D. H., Kottyan, L. C., Lazaro, S., Weaver, C. A., Ice, J. A., Adler, A. J., Chodosh, J., Radfar, L., Rasmussen, A., Stone, D. U., Lewis, D. M., Li, S., Koelsch, K. A., Igoe, A., Talsania, M., Kumar, J. & 58 others, Maier-Moore, J. S., Harris, V. M., Gopalakrishnan, R., Jonsson, R., Lessard, J. A., Lu, X., Gottenberg, J. E., Anaya, J. M., Cunninghame-Graham, D. S., Huang, A. J. W., Brennan, M. T., Hughes, P., Illei, G. G., Miceli-Richard, C., Keystone, E. C., Bykerk, V. P., Hirschfield, G., Xie, G., Ng, W. F., Nordmark, G., Eriksson, P., Omdal, R., Rhodus, N. L., Rischmueller, M., Rohrer, M., Segal, B. M., Vyse, T. J., Wahren-Herlenius, M., Witte, T., Pons-Estel, B., Alarcón-Riquelme, M. E., Guthridge, J. M., James, J. A., Lessard, C. J., Kelly, J. A., Thompson, S. D., Gaffney, P. M., Montgomery, C. G., Edberg, J. C., Kimberly, R. P., Alarcón, G. S., Langefeld, C. L., Gilkeson, G. S., Kamen, D. L., Tsao, B. P., Joseph McCune, W., Salmon, J. E., Merrill, J. T., Weisman, M. H., Wallace, D. J., Utset, T. O., Bottinger, E. P., Amos, C. I., Siminovitch, K. A., Mariette, X., Sivils, K. L., Harley, J. B. & Hal Scofield, R., 1 May 2016, In: Arthritis and Rheumatology. 68, 5, p. 1290-1300 11 p.

    Research output: Contribution to journalArticlepeer-review

  35. Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

    Alarcón-Riquelme, M. E., Ziegler, J. T., Molineros, J., Howard, T. D., Moreno-Estrada, A., Sánchez-Rodríguez, E., Ainsworth, H. C., Ortiz-Tello, P., Comeau, M. E., Rasmussen, A., Kelly, J. A., Adler, A., Acevedo-Vázquez, E. M., Mariano Cucho-Venegas, J., García-De La Torre, I., Cardiel, M. H., Miranda, P., Catoggio, L. J., Maradiaga-Ceceña, M., Gaffney, P. M. & 25 others, Vyse, T. J., Criswell, L. A., Tsao, B. P., Sivils, K. L., Bae, S-C., James, J. A., Kimberly, R. P., Kaufman, K. M., Harley, J. B., Esquivel-Valerio, J. A., Moctezuma, J. F., García, M. A., Berbotto, G. A., Babini, A. M., Scherbarth, H., Toloza, S., Baca, V., Nath, S. K., Aguilar Salinas, C., Orozco, L., Tusié-Luna, T., Zidovetzki, R., Pons-Estel, B. A., Langefeld, C. D. & Jacob, C. O., 1 Apr 2016, In: Arthritis and Rheumatology. 68, 4, p. 932-943 12 p.

    Research output: Contribution to journalArticlepeer-review

  36. Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

    Deng, Y., Zhao, J., Sakurai, D., Sestak, A. L., Osadchiy, V., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., James, J. A., Petri, M. A., Bae, S. C., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Criswell, L. A., Freedman, B. I., Kamen, D. L., Gilkeson, G. S., Jacob, C. O., Merrill, J. T. & 22 others, Gaffney, P. M., Sivils, K. M., Niewold, T. B., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Boackle, S. A., Vilá, L. M., Woong Sohn, I. I., Lee, S., Chang, D. M., Song, Y. W., Vyse, T. J., Harley, J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Cantor, R. M., Hahn, B. H., Grossman, J. M. & Tsao, B. P., 18 Jan 2016, In: Annals of the Rheumatic Diseases. 75, p. 2007-2013

    Research output: Contribution to journalArticlepeer-review

  37. Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry

    Demirci, F. Y., Wang, X., Kelly, J. A., Morris, D. L., Barmada, M. M., Feingold, E., Kao, A. H., Sivils, K. L., Bernatsky, S., Pineau, C., Clarke, A. E., Ramsey-Goldman, R., Vyse, T. J., Gaffney, P. M., Manzi, S. & Kamboh, M. I., 1 Jan 2016, In: Arthritis and Rheumatology. 68, 1, p. 174-183 10 p.

    Research output: Contribution to journalArticlepeer-review

  38. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA

    Zhao, J., Giles, B. M., Taylor, R. L., Yette, G. A., Lough, K. M., Ng, H. L., Abraham, L. J., Wu, H., Kelly, J. A., Glenn, S. B., Adler, A. J., Williams, A. H., Comeau, M. E., Ziegler, J. T., Marion, M., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Bae, S. C., Kim, D. & 28 others, Lee, H. S., Criswell, L. A., Freedman, B. I., Gilkeson, G. S., Guthridge, J. M., Jacob, C. O., James, J. A., Kamen, D. L., Merrill, J. T., Sivils, K. M., Niewold, T. B., Petri, M. A., Ramsey-Goldman, R., Reveille, J. D., Scofield, R. H., Stevens, A. M., Vilá, L. M., Vyse, T. J., Kaufman, K. M., Harley, J. B., Langefeld, C. D., Gaffney, P. M., Brown, E. E., Edberg, J. C., Kimberly, R. P., Ulgiati, D., Tsao, B. P. & Boackle, S. A., Jan 2016, In: Annals of the Rheumatic Diseases. 75, 1, 11 p.

    Research output: Contribution to journalArticlepeer-review

  39. Tartrate-Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus

    An, J., Briggs, T. A., Dumax-vorzet, A., Alarcón-Riquelme, M. E., Belot, A., Beresford, M., Bruce, I. N., Carvalho, C., Chaperot, L., Frostegård, J., Plumas, J., Rice, G. I., Vyse, T. J., Wiedeman, A., Crow, Y. J. & Elkon, K. B., 2016, (Accepted/In press) In: Arthritis and Rheumatology.

    Research output: Contribution to journalArticlepeer-review

  40. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

    Bentham, J., Morris, D. L., Cunninghame Graham, D. S., Pinder, C. L., Tombleson, P., Behrens, T. W., Martín, J., Fairfax, B. P., Knight, J. C., Chen, L., Replogle, J., Syvänen, A. C., Rönnblom, L., Graham, R. R., Wither, J. E., Rioux, J. D., Alarcón-Riquelme, M. E. & Vyse, T., 1 Dec 2015, In: Nature Genetics. 47, 12, p. 1457-1464 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

    Zhao, J., Wu, H., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Bae, S. C., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Criswell, L. A., Freedman, B. I., Kamen, D. L., Gilkeson, G. S., Jacob, C. O., James, J. A., Merrill, J. T., Gaffney, P. M., Sivils, K. M., Niewold, T. B., Petri, M. A. & 84 others, Song, S. T., Jeong, H. J., Ramsey-Goldman, R., Reveille, J. D., Hal Scofield, R., Stevens, A. M., Boackle, S. A., Vilá, L. M., Chang, D. M., Song, Y. W., Vyse, T. J., Harley, J. B., Brown, E. E., Edberg, J. C., Kimberly, R. P., Hahn, B. H., Grossman, J. M., Tsao, B. P., La Cava, A., Frostegård, J., Truedsson, L., de Ramón, E., Sabio, J. M., González-Escribano, M. F., Martin, J., Ortego-Centeno, N., Callejas, J. L., Sánchez-Román, J., D'Alfonso, S., Migliarese, S., Sebastiani, G. D., Galeazzi, M., Witte, T., Lauwerys, B. R., Endreffy, E., Kovács, L., Vasconcelos, C., da Silva, B. M., Scherbarth, H. R., Marino, P. C., Motta, E. L., Gamron, S., Drenkard, C., Menso, E., Allievi, A., Tate, G. A., Presas, J. L., Palatnik, S. A., Abdala, M., Bearzotti, M., Alvarellos, A., Caeiro, F., Bertoli, A., Paira, S., Roverano, S., Graf, C. E., Bertero, E., Caprarulo, C., Buchanan, G., Guillerón, C., Grimaudo, S., Manni, J., Catoggio, L. J., Soriano, E. R., Santos, C. D., Prigione, C., Ramos, F. A., Navarro, S. M., Berbotto, G. A., Jorfen, M., Romero, E. J., Garcia, M. A., Marcos, J. C., Marcos, A. I., Perandones, C. E., Eimon, A., Parque, S., Battagliotti, C. G., Acevedo, E., Cucho, M., de la Torre, I. G., Ríos, M. C., Moctezuma, F. & Maradiaga Ceceña, M., 1 Dec 2015, In: CLINICAL IMMUNOLOGY. 161, 2, p. 157-162 6 p.

    Research output: Contribution to journalArticlepeer-review

  42. Defective removal of ribonucleotides from DNA promotes systemic lupus erythematosus

    Günther, C., Kind, B., Reijns, M. A. M., Berndt, N., Martinez-Bueno, M., Wolf, C., Tüngler, V., Chara, O., Lee, Y. A., Hübner, N., Lee, Y. A., Bicknell, L., Blum, S., Krug, C., Schmidt, F., Krug, C., Kretschmer, S., Koss, S., Astell, K. R., Ramantani, G. & 27 others, Bauerfeind, A., Morris, D. L., Graham, D. S. C., Bubeck, D., Leitch, A., Ralston, S. H., Blackburn, E. A., Gahr, M., Witte, T., Vyse, T. J., Melchers, I., Mangold, E., Nöthen, M. M., Aringer, M., Kuhn, A., Lüthke, K., Unger, L., Bley, A., Lorenzi, A., Isaacs, J. D., Alexopoulou, D., Conrad, K., Dahl, A., Roers, A., Alarcon-Riquelme, M. E., Jackson, A. P. & Lee-Kirsch, M. A., 28 Sep 2015, In: Pediatric Rheumatology. 13, 1, O86.

    Research output: Contribution to journalArticlepeer-review

  43. Reduced fluorescence versus forward scatter time-of-flight and increased peak versus integral fluorescence ratios indicate receptor clustering in flow cytometry

    Fürnrohr, B. G., Stein, M., Rhodes, B., Chana, P. S., Schett, G., Vyse, T. J., Herrmann, M. & Mielenz, D., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 377-385 9 p.

    Research output: Contribution to journalArticlepeer-review

  44. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

    Taylor, J. C., Martin, H. C., Lise, S., Broxholme, J., Cazier, J. B., Rimmer, A., Kanapin, A., Lunter, G., Fiddy, S., Allan, C., Aricescu, A. R., Attar, M., Babbs, C., Becq, J., Beeson, D., Bento, C., Bignell, P., Blair, E., Buckle, V. J., Bull, K. & 90 others, Cais, O., Cario, H., Chapel, H., Copley, R. R., Cornall, R., Craft, J., Dahan, K., Davenport, E. E., Dendrou, C., Devuyst, O., Fenwick, A. L., Flint, J., Fugger, L., Gilbert, R. D., Goriely, A., Green, A., Greger, I. H., Grocock, R., Gruszczyk, A. V., Hastings, R., Hatton, E., Higgs, D., Hill, A., Holmes, C., Howard, M., Hughes, L., Humburg, P., Johnson, D., Karpe, F., Kingsbury, Z., Kini, U., Knight, J. C., Krohn, J., Lamble, S., Langman, C., Lonie, L., Luck, J., McCarthy, D., McGowan, S. J., McMullin, M. F., Miller, K. A., Murray, L., Németh, A. H., Nesbit, M. A., Nutt, D., Ormondroyd, E., Bang Oturai, A., Pagnamenta, A., Patel, S. Y., Percy, M., Petousi, N., Piazza, P., Piret, S. E., Polanco-Echeverry, G., Popitsch, N., Powrie, F., Pugh, C., Quek, L., Robbins, P. A., Robson, K., Russo, A., Sahgal, N., Van Schouwenburg, P. A., Schuh, A., Silverman, E., Simmons, A., Sorensen, P. S., Sweeney, E., Taylor, J., Thakker, R. V., Tomlinson, I., Trebes, A., Twigg, S. R. F., Uhlig, H. H., Vyas, P., Vyse, T., Wall, S. A., Watkins, H., Whyte, M. P., Witty, L., Wright, B., Yau, C., Buck, D., Humphray, S., Ratcliffe, P. J., Bell, J. I., Wilkie, A. O. M., Bentley, D., Donnelly, P. & McVean, G., 26 Jun 2015, In: Nature genetics. 47, 7, p. 717-726 10 p.

    Research output: Contribution to journalArticlepeer-review

  45. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression

    Lu, X., Zoller, E. E., Weirauch, M. T., Wu, Z., Namjou, B., Williams, A. H., Ziegler, J. T., Comeau, M. E., Marion, M. C., Glenn, S. B., Adler, A., Shen, N., Nath, S. K., Stevens, A. M., Freedman, B. I., Tsao, B. P., Jacob, C. O., Kamen, D. L., Brown, E. E., Gilkeson, G. S. & 26 others, Alarcón, G. S., Reveille, J. D., Anaya, J. M., James, J. A., Sivils, K. L., Criswell, L. A., Vilá, L. M., Alarcón-Riquelme, M. E., Petri, M., Scofield, R. H., Kimberly, R. P., Ramsey-Goldman, R., Joo, Y. B., Choi, J., Bae, S. C., Boackle, S. A., Graham, D. C., Vyse, T. J., Guthridge, J. M., Gaffney, P. M., Langefeld, C. D., Kelly, J. A., Greis, K. D., Kaufman, K. M., Harley, J. B. & Kottyan, L. C., 7 May 2015, In: American Journal of Human Genetics. 96, 5, p. 731-739 9 p.

    Research output: Contribution to journalArticlepeer-review

Previous 1 2 3 Next

Export:RIS BibTex Word PDF - will at most contain 500 items

Search within the list

Refine results

Language

Language

Publication year

Publication year

Meeting and poster abstracts

Meeting and poster abstracts

Open Access Status

Open Access Status

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454