Timothy Tree

2025

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial

Bensimon, G., Leigh, P. N., Tree, T., Malaspina, A., Payan, C. A., Pham, H.-P., Klaassen, P., Shaw, P. J., Al Khleifat, A., Amador, M. D. M., Attarian, S., Bell, S. M., Beltran, S., Bernard, E., Camu, W., Corcia, P., Corvol, J.-C., Couratier, P., Danel, V. & Debs, R. & 30 others, Desnuelle, C., Dimitriou, A., Ealing, J., Esselin, F., Fleury, M.-C., Gorrie, G. H., Grapperon, A.-M., Hesters, A., Juntas-Morales, R., Kolev, I., Lautrette, G., Le Forestier, N., McDermott, C. J., Pageot, N., Salachas, F., Sharma, N., Soriani, M.-H., Sreedharan, J., Svahn, J., Verber, N., Verschueren, A., Yildiz, O., Suehs, C. M., Saker-Delye, S., Muller, C., Masseguin, C., Hajduchova, H., Garlanda, C., Locati, M. & Al-Chalabi, A., 9 May 2025, (E-pub ahead of print) In: Lancet.

Research output: Contribution to journal › Article › peer-review

Meeting Report: The Sixth International Sam Strober Workshop on Clinical Immune Tolerance

Stark, H., Ho, Q. Y., Cross, A., Alessandrini, A., Bertaina, A., Brennan, D., Busque, S., Demetris, A., Devey, L., Fruhwirth, G., Fuchs, E., Friend, P., Geissler, E., Guillonneau, C., Hester, J., Isaacs, J., Jaeckel, E., Kawai, T., Lakkis, F. & Leventhal, J. & 21 others, Levings, M., Levitsky, J., Lombardi, G., Martinez-Llordella, M., Mathew, J., Moreau, A., Reinke, P., Riella, L. V., Sachs, D., Fueyo, A. S., Schreeb, K., Sykes, M., Tang, Q., Thomson, A., Tree, T., Trzonkowski, P., Uchida, K., Veale, J., Weiner, J., Wekerle, T. & Issa, F., 1 Apr 2025, In: Transplantation. 109, 4, p. 569-579 11 p., 005311.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2024

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

INNODIA investigators, 18 Jun 2024, In: Cell Reports Medicine. 5, 6, p. 101591 101591.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

EXE-T1D Consortium, Johnson, M. B., Ogishi, M., Domingo-Vila, C., De Franco, E., Wakeling, M. N., Imane, Z., Resnick, B., Williams, E., Galão, R. P., Caswell, R., Russ-Silsby, J., Seeleuthner, Y., Rinchai, D., Fagniez, I., Benson, B., Dufort, M. J., Speake, C., Smithmyer, M. E. & Hudson, M. & 9 others, Dobbs, R., Quandt, Z., Hattersley, A. T., Zhang, P., Boisson-Dupuis, S., Anderson, M. S., Casanova, J. L., Tree, T. I. & Oram, R. A., 3 Jun 2024, In: The Journal of experimental medicine. 221, 6, e20231704.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

2023

Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis

Yildiz, O., Schroth, J., Tree, T., Turner, M. R., Shaw, P. J., Henson, S. M. & Malaspina, A., 2 Jan 2023, In: Neurology: Neuroimmunology and NeuroInflammation. 10, 1, e200042.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

Hanna, S. J., Thayer, T. C., Robinson, E. J. S., Vinh, N. N., Williams, N., Landry, L. G., Andrews, R., Siah, Q. Z., Leete, P., Wyatt, R., McAteer, M. A., Nakayama, M., Wong, F. S., Yang, J. H. M., Tree, T. I. M., Ludvigsson, J., Dayan, C. M. & Tatovic, D., 2023, In: Frontiers in Immunology. 14, 1276255.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

2022

Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

McKenzie, D. R., Graham, R., Lechmere, T., Domingo-Vila, C., Alaguthurai, T., Arman, C., Pollock, E., Gousis, C., Kakkassery, H., Carpenter, E., Kurshan, A., Vidler, J., Kulasekararaj, A., Patten, P., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 2022, In: Cancer research communications. 2, 11, p. 1449-1461 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Boosting of Waned Humoral and Cellular Responses to SARS-CoV-2 Variants of Concern Among Patients with Cancer

McKenzie, D. R., Graham, R., Lechmere, T., Domingo-Vila, C., Alaguthurai, T., Arman, C., Pollock, E., Gousis, C., Kakkassery, H., Carpenter, E., Kurshan, A., Vidler, J., Kulasekararaj, A., Patten, P., North, B. V., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., 17 Nov 2022, In: Cancer research communications. 2, 11, p. 1449-1461 13 p.

Research output: Contribution to journal › Article › peer-review

Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19

Österdahl, M. F., Christakou, E., Hart, D., Harris, F., Shahrabi, Y., Pollock, E., Wadud, M., Spector, T. D., Brown, M. A., Seow, J., Malim, M. H., Steves, C. J., Doores, K. J., Duncan, E. L. & Tree, T., Nov 2022, In: Journal of Medical Virology. 94, 11, p. 5217-5224 8 p.

Research output: Contribution to journal › Article › peer-review

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5 Citations (Scopus)

209 Downloads (Pure)

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

Immunology of Diabetes Society T-Cell Cytometry Group, Yang, J. H. M., Ward-Hartstonge, K. A., Perry, D. J., Blanchfield, J. L., Posgai, A. L., Wiedeman, A. E., Diggins, K., Rahman, A., Tree, T. I. M., Brusko, T. M., Levings, M. K., James, E. A., Kent, S. C., Speake, C., Homann, D. & Long, S. A., 4 Mar 2022, In: European Journal of Immunology. 52, 3, p. 372-388 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study

Mahil, S. K., Bechman, K., Raharja, A., Domingo-Vila, C., Baudry, D., Brown, M. A., Cope, A. P., Dasandi, T., Graham, C., Khan, H., Lechmere, T., Malim, M. H., Meynell, F., Pollock, E., Sychowska, K., Barker, J. N., Norton, S., Galloway, J. B., Doores, K. J. & Tree, T. & 1 others, Smith, C. H., Jan 2022, In: The Lancet Rheumatology. 4, 1, p. e42-e52

Research output: Contribution to journal › Article › peer-review

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70 Citations (Scopus)

116 Downloads (Pure)

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Liu, Y. F., Powrie, J., Arif, S., Yang, J. H. M., Williams, E., Khatri, L., Joshi, M., Lhuillier, L., Fountoulakis, N., Smith, E., Beam, C., Lorenc, A., Peakman, M. & Tree, T., 1 Apr 2022, In: Diabetes. 71, 4, p. 722-732 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Citations (Scopus)

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

on behalf of the INNODIA consortium, Dec 2022, In: Trials. 23, 1, 414.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Low-dose IL-2 reduces IL-21⁺ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

Zhang, J. Y., Hamey, F., Trzupek, D., Mickunas, M., Lee, M., Godfrey, L., Yang, J. H. M., Pekalski, M. L., Kennet, J., Waldron-Lynch, F., Evans, M. L., Tree, T. I. M., Wicker, L. S., Todd, J. A. & Ferreira, R. C., Dec 2022, In: Nature Communications. 13, 1, 7324.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

The Expression of Active CD11b Monocytes in Blood and Disease Progression in Amyotrophic Lateral Sclerosis

Yildiz, O., Schroth, J., Lombardi, V., Pucino, V., Bobeva, Y., Yip, P. K., Schmierer, K., Mauro, C., Tree, T., Henson, S. M. & Malaspina, A., 21 Mar 2022, In: International Journal of Molecular Sciences. 23, 6, 3370.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

2021

Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2

Tree, T., 29 Jun 2021, In: Brain Communications. 3, 3

Research output: Contribution to journal › Article › peer-review

Open Access

21 Citations (Scopus)

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Marwaha, A. K., Chow, S., Pesenacker, A. M., Cook, L., Sun, A., Long, S. A., Yang, J. H. M., Ward-Hartstonge, K. A., Williams, E., Domingo-Vila, C., Halani, K., Harris, K. M., Tree, T. I. M., Levings, M. K., Elliott, T., Tan, R. & Dutz, J. P., 13 Nov 2021, (E-pub ahead of print) In: Immunotherapy advances. 2, 1

Research output: Contribution to journal › Article › peer-review

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15 Citations (Scopus)

49 Downloads (Pure)

Augmented Expansion of Treg Cells From Healthy and Autoimmune Subjects via Adult Progenitor Cell Co-Culture

Reading, J. L., Roobrouck, V. D., Hull, C. M., Becker, P. D., Beyens, J., Valentin-torres, A., Boardman, D., Lamperti, E. N., Stubblefield, S., Lombardi, G., Deans, R., Ting, A. E. & Tree, T., 1 Sept 2021, In: Frontiers in Immunology. 12, 716606.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H. D., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., Bacher, P., Bari, S., Barnaba, V., Barros-Martins, J., Baumjohann, D., Beccaria, C. G., Bernardo, D., Boardman, D. A., Borger, J. & Böttcher, C. & 173 others, Brockmann, L., Burns, M., Busch, D. H., Cameron, G., Cammarata, I., Cassotta, A., Chang, Y., Chirdo, F. G., Christakou, E., Čičin-Šain, L., Cook, L., Corbett, A. J., Cornelis, R., Cosmi, L., Davey, M. S., De Biasi, S., De Simone, G., del Zotto, G., Delacher, M., Di Rosa, F., Santo, J. D., Diefenbach, A., Dong, J., Dörner, T., Dress, R. J., Dutertre, C. A., Eckle, S. B. G., Eede, P., Evrard, M., Falk, C. S., Feuerer, M., Fillatreau, S., Fiz-Lopez, A., Follo, M., Foulds, G. A., Fröbel, J., Gagliani, N., Galletti, G., Gangaev, A., Garbi, N., Garrote, J. A., Geginat, J., Gherardin, N. A., Gibellini, L., Ginhoux, F., Godfrey, D. I., Gruarin, P., Haftmann, C., Hansmann, L., Harpur, C. M., Hayday, A. C., Heine, G., Hernández, D. C., Herrmann, M., Hoelsken, O., Huang, Q., Huber, S., Huber, J. E., Huehn, J., Hundemer, M., Hwang, W. Y. K., Iannacone, M., Ivison, S. M., Jäck, H. M., Jani, P. K., Keller, B., Kessler, N., Ketelaars, S., Knop, L., Knopf, J., Koay, H. F., Kobow, K., Kriegsmann, K., Kristyanto, H., Krueger, A., Kuehne, J. F., Kunze-Schumacher, H., Kvistborg, P., Kwok, I., Latorre, D., Lenz, D., Levings, M. K., Lino, A. C., Liotta, F., Long, H. M., Lugli, E., MacDonald, K. N., Maggi, L., Maini, M. K., Mair, F., Manta, C., Manz, R. A., Mashreghi, M. F., Mazzoni, A., McCluskey, J., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Monin, L., Moretta, L., Multhoff, G., Muñoz, L. E., Muñoz-Ruiz, M., Muscate, F., Natalini, A., Neumann, K., Ng, L. G., Niedobitek, A., Niemz, J., Almeida, L. N., Notarbartolo, S., Ostendorf, L., Pallett, L. J., Patel, A. A., Percin, G. I., Peruzzi, G., Pinti, M., Pockley, A. G., Pracht, K., Prinz, I., Pujol-Autonell, I., Pulvirenti, N., Quatrini, L., Quinn, K. M., Radbruch, H., Rhys, H., Rodrigo, M. B., Romagnani, C., Saggau, C., Sakaguchi, S., Sallusto, F., Sanderink, L., Sandrock, I., Schauer, C., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schober, K., Schoen, J., Schuh, W., Schüler, T., Schulz, A. R., Schulz, S., Schulze, J., Simonetti, S., Singh, J., Sitnik, K. M., Stark, R., Starossom, S., Stehle, C., Szelinski, F., Tan, L., Tarnok, A., Tornack, J., Tree, T. I. M., van Beek, J. J. P., van de Veen, W., van Gisbergen, K., Vasco, C., Verheyden, N. A., von Borstel, A., Ward-Hartstonge, K. A., Warnatz, K., Waskow, C., Wiedemann, A., Wilharm, A., Wing, J., Wirz, O., Wittner, J., Yang, J. H. M. & Yang, J., Dec 2021, In: European Journal of Immunology. 51, 12, p. 2708-3145 438 p.

Research output: Contribution to journal › Article › peer-review

Open Access

288 Citations (Scopus)

Historical and new insights into pathogenesis of type 1 diabetes (2)

Wong, F. S. & Tree, T. I., 23 Apr 2021, In: Clinical and Experimental Immunology. 204, 2, p. 165-166 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Identifying the ‘Achilles heel’ of type 1 diabetes

Battaglia, M., Buckner, J. H., Levings, M. K., Richardson, S. J., Wong, F. S. & Tree, T. I., 23 Apr 2021, In: Clinical and Experimental Immunology. 204, 2, p. 167-178 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects

Arif, S., Pujol-Autonell, I., Kamra, Y., Williams, E., Yusuf, N., Domingo-Vila, C., Shahrabi, Y., Pollock, E., Khatri, L., Peakman, M., Tree, T. & Lorenc, A., 25 Jun 2021, In: Frontiers in Immunology. 12, 675746.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)

Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): Trial protocol

Gregory, J. W., Carter, K., Cheung, W. Y., Holland, G., Bowen-Morris, J., Luzio, S., Dunseath, G., Tree, T., Yang, J. H. M., Marwaha, A., Ali, M. A., Bashir, N., Hutchings, H. A., Fegan, G. W., Stenson, R., Hiles, S., Marques-Jones, S., Brown, A., Tatovic, D. & Dayan, C., 18 Oct 2021, In: BMJ Open. 11, 10, e049595.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

Monin, L., Laing, A. G., Muñoz-Ruiz, M., McKenzie, D. R., Del Molino Del Barrio, I., Alaguthurai, T., Domingo-Vila, C., Hayday, T. S., Graham, C., Seow, J., Abdul-Jawad, S., Kamdar, S., Harvey-Jones, E., Graham, R., Cooper, J., Khan, M., Vidler, J., Kakkassery, H., Sinha, S. & Davis, R. & 24 others, Dupont, L., Francos Quijorna, I., O'Brien-Gore, C., Lee, P. L., Eum, J., Conde Poole, M., Joseph, M., Davies, D., Wu, Y., Swampillai, A., North, B. V., Montes, A., Harries, M., Rigg, A., Spicer, J., Malim, M. H., Fields, P., Patten, P., Di Rosa, F., Papa, S., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., Jun 2021, In: The Lancet Oncology. 22, 6, p. 765-778 14 p.

Research output: Contribution to journal › Article › peer-review

467 Citations (Scopus)

Study protocol: Minimum effective low dose: Anti-human thymocyte globulin (MELD-ATG): Phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes

Wilhelm-Benartzi, C. S., Miller, S. E., Bruggraber, S., Picton, D., Wilson, M., Gatley, K., Chhabra, A., Marcovecchio, M. L., Hendriks, A. E. J., Morobé, H., Chmura, P. J., Bond, S., Aschemeier-Fuchs, B., Knip, M., Tree, T., Overbergh, L., Pall, J., Arnaud, O., Haller, M. J. & Nitsche, A. & 4 others, Schulte, A. M., Mathieu, C., Mander, A. & Dunger, D., 7 Dec 2021, In: BMJ Open. 11, 12, e053669.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study

Tree, T., Sept 2021, In: The Lancet Rheumatology. 3, 9, p. e627-e637

Research output: Contribution to journal › Article › peer-review

Open Access

136 Citations (Scopus)

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

Gee, S., Chandiramani, M., Seow, J., Pollock, E., Modestini, C., Das, A., Tree, T., Doores, K., Tribe, R. & Gibbons, D., Dec 2021, In: Nature Immunology. 22, 12, p. 1490-1502 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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88 Citations (Scopus)

70 Downloads (Pure)

The transCampus Metabolic Training Programme Explores the Link of SARS-CoV-2 Virus to Metabolic Disease

Bornstein, S. R., Guan, K., Brunβen, C., Mueller, G., Kamvissi-Lorenz, V., Lechler, R., Trembath, R., Mayr, M., Poston, L., Sancho, R., Ahmed, S., Alfar, E., Aljani, B., Alves, T. C., Amiel, S., Andoniadou, C. L., Bandral, M., Belavgeni, A., Berger, I. & Birkenfeld, A. & 74 others, Bonifacio, E., Chavakis, T., Chawla, P., Choudhary, P., Cujba, A. M., Delgadillo Silva, L. F., Demcollari, T., Drotar, D. M., Duin, S., El-Agroudy, N. N., El-Armouche, A., Eugster, A., Gado, M., Gavalas, A., Gelinsky, M., Guirgus, M., Hansen, S., Hanton, E., Hasse, M., Henneicke, H., Heller, C., Hempel, H., Hogstrand, C., Hopkins, D., Jarc, L., Jones, P. M., Kamel, M., Kämmerer, S., King, A. J. F., Kurzbach, A., Lambert, C., Latunde-Dada, Y., Lieberam, I., Liers, J., Li, J. W., Linkermann, A., Locke, S., Ludwig, B., Manea, T., Maremonti, F., Marinicova, Z., McGowan, B. M., Mickunas, M., Mingrone, G., Mohanraj, K., Morawietz, H., Ninov, N., Peakman, M., Persaud, S. J., Pietzsch, J., Cachorro, E., Pullen, T. J., Pyrina, I., Rubino, F., Santambrogio, A., Schepp, F., Schlinkert, P., Scriba, L. D., Siow, R., Solimena, M., Spagnoli, F. M., Speier, S., Stavridou, A., Steenblock, C., Strano, A., Taylor, P., Tiepner, A., Tonnus, W., Tree, T., Watt, F., Werdermann, M., Wilson, M., Yusuf, N. & Ziegler, C. G., 1 Mar 2021, In: Hormone and Metabolic Research. 53, 3, p. 204-206 3 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2020

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells

Arif, S., Gomez-Tourino, I., Kamra, Y., Pujol-Autonell, I., Hanton, E., Tree, T., Melandri, D., Hull, C., Wherrett, D. K., Beam, C., Roep, B. O., Lorenc, A. & Peakman, M., 1 Jun 2020, In: Diabetologia. 63, 6, p. 1186-1198 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial

Camu, W., Mickunas, M., Veyrune, J.-L., Payan, C., Garlanda, C., Locati, M., Juntas-Morales, R., Pageot, N., Malaspina, A., Andreasson, U., Kirby, J., Suehs, C., Saker, S., Masseguin, C., De Vos, J., Zetterberg, H., Shaw, P. J., Al-Chalabi, A., Leigh, P. N. & Tree, T. & 1 others, Bensimon, G., Sept 2020, In: EBioMedicine. 59, p. 102844 102844.

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Tracking immunodynamics by identification of S-G₂/M-phase T cells in human peripheral blood

Muñoz-Ruiz, M., Pujol-Autonell, I., Rhys, H., Long, H. M., Greco, M., Peakman, M., Tree, T., Hayday, A. C. & Di Rosa, F., Aug 2020, In: Journal of Autoimmunity. 112, 102466.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells

EXE-T1D Consortium, 1 Dec 2020, In: Diabetologia. 63, 12, p. 2605-2615 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Citations (Scopus)

2019

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression

Ferreira, R. C., Castro Dopico, X., Oliveira, J. J., Rainbow, D. B., Yang, J. H., Trzupek, D., Todd, S. A., McNeill, M., Steri, M., Orrù, V., Fiorillo, E., Crouch, D. J. M., Pekalski, M. L., Cucca, F., Tree, T. I., Vyse, T. J., Wicker, L. S. & Todd, J. A., 8 Nov 2019, In: Frontiers in Immunology. 10, 2606.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Citations (Scopus)

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S. & Barnaba, V. & 416 others, Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Čičin-Šain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., 1 Oct 2019, In: European Journal of Immunology. 49, 10, p. 1457-1973 517 p.

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776 Citations (Scopus)

Persistent C-peptide is associated with reduced hypoglycaemia but not HbA_1c in adults with longstanding Type 1 diabetes: evidence for lack of intensive treatment in UK clinical practice?

on behalf of the TIGI consortium, 6 Apr 2019, (E-pub ahead of print) In: Diabetic Medicine. 36, 9, p. 1092-1099 8 p.

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34 Citations (Scopus)

Phenotypic analysis of human lymph nodes in subjects with new-onset type 1 diabetes and healthy individuals by flow cytometry

Yang, J. H. M., Khatri, L., Mickunas, M., Williams, E., Tatovic, D., Ali, M. A., Young, P., Moyle, P., Sahni, V., Wang, R., Kaur, R., Tannahill, G. M., Beaton, A. R., Gerlag, D. M., Savage, C. O. S., Rosen, A. N., Waldron-Lynch, F., Dayan, C. M. & Tree, T. I. M., 1 Jan 2019, In: Frontiers in Immunology. 10, OCT, 2547.

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14 Citations (Scopus)

Standardizing T-Cell biomarkers in type 1 diabetes: Challenges and recent advances

Ahmed, S., Cerosaletti, K., James, E., Long, S. A., Mannering, S., Speake, C., Nakayama, M., Tree, T., Roep, B. O., Herold, K. C. & Brusko, T. M., 1 Jan 2019, In: Diabetes. 68, 7, p. 1366-1379 14 p.

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52 Citations (Scopus)

2018

Multipotent Adult Progenitor Cells Suppress T Cell Activation in Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner

Carty, F., Corbett, J. M., Cunha, J. P. M. C. M., Reading, J. L., Tree, T. I. M., Ting, A. E., Stubblefield, S. R. & English, K., 23 Apr 2018, In: Frontiers in Immunology. 9, 645.

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13 Citations (Scopus)

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2017

Generation of human islet-specific regulatory T cells by TCR gene transfer

Hull, C. M., Nickolay, L. E., Estorninho, M., Richardson, M. W., Riley, J. L., Peakman, M., Maher, J. & Tree, T. I. M., 31 May 2017, In: Journal of Autoimmunity. 79, p. 63-73

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106 Citations (Scopus)

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IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

Whitehouse, G., Gray, E., Mastoridis, S., Merritt, E., Kodela, E., Yang, J. H. M., Danger, R., Mairal, M., Christakoudi, S., Lozano, J. J., Macdougall, I. C., Tree, T. I. M., Sanchez-Fueyo, A. & Martinez-Llordella, M., 3 Jul 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7083-7088 6 p.

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96 Citations (Scopus)

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

Ali, M. A., Liu, Y.-F., Arif, S., Tatovic, D., Shariff, H., Gibson, V. B., Yusuf, N., Baptista, R., Eichmann, M., Petrov, N., Heck, S., Yang, J. H. M., Tree, T. I. M., Pujol-Autonell, I., Yeo, L., Baumard, L. R., Stenson, R., Howell, A., Clark, A. & Boult, Z. & 19 others, Powrie, J., Adams, L., Wong, F. S., Luzio, S., Dunseath, G., Green, K., O'Keefe, A., Bayly, G., Thorogood, N., Andrews, R., Leech, N., Joseph, F., Nair, S., Seal, S., Cheung, H., Beam, C., Hills, R., Peakman, M. & Dayan, C. M., 9 Aug 2017, In: Science Translational Medicine. 9, 402, 10 p., eaaf7779.

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160 Citations (Scopus)

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Metabolic and immune effects of immunotherapy with proinsulin peptide in new-onset type 1 diabetes

Peakman, M., Alhadj Ali, M., Arif, S., Gibson, V., Yusuf, N., Tree, T. I. M., Pujol Autonell, I., Yeo, L. & Dayan, C., 1 Aug 2017, In: Science Translational Medicine. 9, 9

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Regulatory T cell dysfunction in type 1 diabetes: what's broken and how can we fix it?

Hull, C. M., Peakman, M. & Tree, T. I. M., 2 Aug 2017, (E-pub ahead of print) In: Diabetologia. 60, 10, p. 2661 - 2807 12 p.

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151 Citations (Scopus)

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2016

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Todd, J. A., Evangelou, M., Cutler, A. J., Pekalski, M. L., Walker, N. M., Stevens, H. E., Porter, L., Smyth, D. J., Rainbow, D. B., Ferreira, R. C., Esposito, L., Hunter, K. M. D., Loudon, K., Irons, K., Yang, J. H., Bell, C. J. M., Schuilenburg, H., Heywood, J., Challis, B. & Neupane, S. & 18 others, Clarke, P., Coleman, G., Dawson, S., Goymer, D., Anselmiova, K., Kennet, J., Brown, J., Caddy, S. L., Lu, J., Greatorex, J., Goodfellow, I., Wallace, C., Tree, T. I., Evans, M., Mander, A. P., Bond, S., Wicker, L. S. & Waldron-Lynch, F., 11 Oct 2016, In: PL o S Medicine. 13, 10, e1002139.

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108 Citations (Scopus)

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Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis

Lu, C.-H., Allen, K., Oei, F., Leoni, E., Kuhle, J., Tree, T., Fratta, P., Sharma, N., Sidle, K., Howard, R., Orrell, R., Fish, M., Greensmith, L., Pearce, N., Gallo, V. & Malaspina, A., Aug 2016, In: Neurology® neuroimmunology & neuroinflammation. 3, 4, p. e244

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2015

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Yang, J. H. M., Cutler, A. J., Ferreira, R. C., Reading, J. L., Cooper, N. J., Wallace, C., Clarke, P., Smyth, D. J., Boyce, C. S., Gao, G.-J., Todd, J. A., Wicker, L. S. & Tree, T. I. M., 30 Nov 2015, In: Diabetes. 64, 11, p. 3891-902 12 p.

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49 Citations (Scopus)

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

Mason, G. M., Lowe, K., Melchiotti, R., Ellis, R., de Rinaldis, E., Peakman, M., Heck, S., Lombardi, G. & Tree, T. I. M., 1 Sept 2015, In: Journal of Immunology. 195, 5, p. 2030-2037 8 p.

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116 Citations (Scopus)

Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2

Reading, J. L., Vaes, B., Hull, C., Sabbah, S., Hayday, T., Wang, N. S., DiPiero, A., Lehman, N. A., Taggart, J. M., Carty, F., English, K., Pinxteren, J., Deans, R., Ting, A. E. & Tree, T. I. M., 1 Nov 2015, In: Molecular Therapy. 23, 11, p. 1783-1793

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37 Citations (Scopus)

2014

Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis

Zhao, Y., Lutalo, P. M. K., Thomas, J. E., Sangle, S., Choong, L. M., Tyler, J. R., Tree, T., Spencer, J. & D’Cruz, D., Apr 2014, In: Rheumatology. 53, 4, p. 621-630 10 p.

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50 Citations (Scopus)

2013

CD161 expression characterizes a sub-population of human regulatory T cells that produces IL-17 in a STAT3 dependent manner

Afzali, B., Mitchell, P. J., Edozie, F. C., Povoleri, G. A. M., Dowson, S. E., Demandt, L., Walter, G., Canavan, J. B., Scotta, C., Menon, B., Chana, P. S., Khamri, W., Kordasti, S., Heck, S., Grimbacher, B., Tree, T., Cope, A. P., Taams, L. S., Lechler, R. I. & John, S. & 1 others, Lombardi, G., Aug 2013, In: European Journal of Immunology. 43, 8, p. 2043-2054 12 p.

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Timothy Tree

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