Personal profile
Research interests
- Genetics
- Immunology of autoimmunity
- Immunogenetics
- Genetics of SLE (lupus)
Biographical details
I trained in Natural Sciences at Trinity Hall, Cambridge and then Medicine at Guy’s Hospital Medical School. I undertook further clinical training in London at Queen Square and Hammersmith Hospital and then a PhD at University of London. My post-doctoral training was at the National Jewish Center for Immunology in Denver, Colorado.
I was thereafter awarded a Wellcome Trust Senior Clinical Fellowship, during which I worked at Imperial College London, becoming Professor of Rheumatology. I moved to King’s in 2010, having obtained a personal Chair in Molecular Medicine.
Education/Academic qualification
Doctor of Philosophy, University of London
Award Date: 1 Jan 1994
Bachelor of Arts, University of Cambridge
Award Date: 1 Jan 1982
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Cross-talk between ILC2 and Gata3high Tregs locally constrains adaptive type 2 immunity
Stockis, J., Yip, T., Moreno-Vicente, J., Burton, O., Samarakoon, Y., Schuijs, M. J., Raghunathan, S., Garcia, C., Luo, W., Whiteside, S. K., Png, S., Simpson, C., Monk, S., Sawle, A., Yin, K., Barbieri, J., Papadopoulos, P., Wong, H., Rodewald, H.-R. & Vyse, T. & 8 others, , 19 Jul 2024, In: Science Immunology. 9, 97, eadl1903.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)109 Downloads (Pure) -
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms
Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., Van heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Beecham, A. H., Patsopoulos, N. A., Cotsapas, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B. & Claes, M. & 34 others, , May 2024, In: Nature Genetics. 56, 5, p. 838-845 8 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosus
Roberts, A., Morea, A., Amar, A., West, M., Karrar, S., Lehane, R., Tombleson, P., Cunninghame Graham, D., Reynolds, J., Wong, C., Morris, D., Small, K. & Vyse, T., 27 Jun 2024, In: Annals of the Rheumatic Diseases.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)166 Downloads (Pure) -
A review of genetic risk in systemic lupus erythematosus
Guga, S., Wang, Y., Graham, D. C. & Vyse, T. J., 19 Oct 2023, In: Expert Review Of Clinical Immunology. 19, 10, p. 1247-1258Research output: Contribution to journal › Article › peer-review
Open Access26 Citations (Scopus) -
Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans
Roberts, A., Morea, A., Amar, A., Zito, A., El-Sayed Moustafa, J., Tomlinson, M., Bowyer, R., Zhang, X., Christiansen, C., de Oliveira Costeira, R. C., Steves, C., Mangino, M., Bell, J., Wong, C., Vyse, T. & Small, K., 22 Nov 2022, In: eLife. 11Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus)
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Molecular profiles and genetic origins of Ancestral phenotypic diversity
Vyse, T. (Primary Investigator)
1/10/2023 → 30/09/2026
Project: Research
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Factors maintaining tertiary lymphoid aggregates in Discoid Lupus Erythematosus
Vyse, T. (Primary Investigator), Cunninghame Graham, D. (Co-Investigator) & Tull, T. (Co-Investigator)
1/06/2026 → 31/05/2028
Project: Research
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Understanding sex bias in lupus: Genes, Genetics and Mechanism of Escape from X inactivation
Cunninghame Graham, D. (Primary Investigator) & Vyse, T. (Co-Investigator)
1/04/2026 → 31/03/2027
Project: Research
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sOX40 and sOX40L: genetically motivated biomarkers with prognostic and predictive potential in SLE
Cunninghame Graham, D. (Primary Investigator) & Vyse, T. (Co-Investigator)
1/04/2026 → 31/03/2028
Project: Research
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Investigating an X chromosome gene CXorf21: a cause of gender bias in SLE?
Vyse, T. (Primary Investigator) & Cunninghame Graham, D. (Co-Investigator)
Project: Research
Datasets
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COVID-19 and systemic lupus erythematosus genetics: a balance between autoimmune disease risk and protection against infection
Wang, Y., Guga, S., Wu, K., Khaw, Z., Tzoumkas, K., Tombleson, P., E. Comeau, M., D. Langefeld, C., Cunninghame Graham, D., Morris, D. & Vyse, T., King's College London, 30 Sept 2022
DOI: 10.18742/19758484, https://kcl.figshare.com/articles/dataset/COVID-19_and_systemic_lupus_erythematosus_genetics_a_balance_between_autoimmune_disease_risk_and_protection_against_infection/19758484
Dataset