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Timothy Vyse

Timothy Vyse

Professor

 https://orcid.org/0000-0003-1123-1464

    • SE1 9RT

      United Kingdom

    • 13423
      Citations

    Personal profile

    Research interests

    • Genetics
    • Immunology of autoimmunity
    • Immunogenetics
    • Genetics of SLE (lupus)

    Biographical details

    I trained in Natural Sciences at Trinity Hall, Cambridge and then Medicine at Guy’s Hospital Medical School. I undertook further clinical training in London at Queen Square and Hammersmith Hospital and then a PhD at University of London. My post-doctoral training was at the National Jewish Center for Immunology in Denver, Colorado.

    I was thereafter awarded a Wellcome Trust Senior Clinical Fellowship, during which I worked at Imperial College London, becoming Professor of Rheumatology. I moved to King’s in 2010, having obtained a personal Chair in Molecular Medicine.

    Education/Academic qualification

    Doctor of Philosophy, University of London

    Award Date: 1 Jan 1994

    Bachelor of Arts, University of Cambridge

    Award Date: 1 Jan 1982

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being
    2. SDG 7 - Affordable and Clean Energy
      SDG 7 Affordable and Clean Energy
    3. SDG 10 - Reduced Inequalities
      SDG 10 Reduced Inequalities

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    • Shared genetic architecture of schizophrenia and lupus identifies pleiotropic loci with distinct downstream mechanisms.

      Gong, C., Dand, N., Butler, A., Amar, A., Liu, L., Triantafyllou, P., Morris, D. & Vyse, T., 10 Sept 2026, (Accepted/In press) In: Human Molecular Genetics.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File

    • The adaptor protein TASL is required for age related B cell emergence and lupus-like disease development in mice

      JOHNSTONE, J. C., MITCHELL, R., VYSE, T. J. & CLARKE, A. J., Jan 2026, In: PLoS Biology. 24, 3, p. 1-17 17 p., e3003342.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File
      1 Citation (Scopus)

    • Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

      Wiley, M. M., Radziszewski, M., Khatri, B., Joachims, M. L., Tessneer, K. L., Stolarczyk, A. M., Yao, S., Li, J., Pritchett-Frazee, C., Johnston, A. A., Rasmussen, A., Anaya, J. M., Aqrawi, L. A., Bae, S. C., Baecklund, E., Björk, A., Brun, J. G., Bucher, S. M., Dand, N. & Eloranta, M. L. & 60 others, Engelke, F., Forsblad-d'Elia, H., Fugmann, C., Glenn, S. B., Gong, C., Gottenberg, J. E., Hammenfors, D., Imgenberg-Kreuz, J., Jensen, J. L., Johnsen, S. J. A., Jonsson, M. V., Kelly, J. A., Khanam, S., Kim, K., Kvarnström, M., Mandl, T., Martín, J., Morris, D. L., Nocturne, G., Norheim, K. B., Olsson, P., Palm, Ø., Pers, J. O., Rhodus, N. L., Sjöwall, C., Skarstein, K., Taylor, K. E., Tombleson, P., Thorlacius, G. E., Venuturupalli, S. R., Vital, E. M., Wallace, D. J., Radfar, L., Brennan, M. T., James, J. A., Scofield, R. H., Gaffney, P. M., Criswell, L. A., Jonsson, R., Appel, S., Eriksson, P., Bowman, S. J., Omdal, R., Rönnblom, L., Warner, B. M., Rischmueller, M., Witte, T., Farris, A. D., Mariette, X., Shiboski, C. H., Wahren-Herlenius, M., Alarcón-Riquelme, M. E., Ng, W. F., Sivils, K. L., Guthridge, J. M., Adrianto, I., Vyse, T. J., Tsao, B. P., Nordmark, G. & Lessard, C. J., Sept 2025, In: Annals of the rheumatic diseases. 84, 9, p. 1512-1527 16 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Citations (Scopus)

    • Cross-talk between ILC2 and Gata3high Tregs locally constrains adaptive type 2 immunity

      Stockis, J., Yip, T., Moreno-Vicente, J., Burton, O., Samarakoon, Y., Schuijs, M. J., Raghunathan, S., Garcia, C., Luo, W., Whiteside, S. K., Png, S., Simpson, C., Monk, S., Sawle, A., Yin, K., Barbieri, J., Papadopoulos, P., Wong, H., Rodewald, H.-R. & Vyse, T. & 8 others, Mckenzie, A. N. J., Cragg, M. S., Hoare, M., Withers, D. R., Fehling, H. J., Roychoudhuri, R., Liston, A. & Halim, T. Y. F., 19 Jul 2024, In: Science Immunology. 9, 97, eadl1903.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      File
      29 Citations (Scopus)
      164 Downloads (Pure)

    • Genetic mapping across autoimmune diseases reveals shared associations and mechanisms

      Lincoln, M. R., Connally, N., Axisa, P.-P., Gasperi, C., Mitrovic, M., Van heel, D., Wijmenga, C., Withoff, S., Jonkers, I. H., Padyukov, L., Beecham, A. H., Patsopoulos, N. A., Cotsapas, C., Booth, D., Goris, A., Oturai, A., Saarela, J., Fontaine, B., Hemmer, B. & Claes, M. & 34 others, Zipp, F., D’alfonso, S., Martinelli-Boneschi, F., Taylor, B., Harbo, H. F., Kockum, I., Hillert, J., Olsson, T., Oksenberg, J. R., Hintzen, R., Barcellos, L. F., Alfredsson, L., Esposito, F., Martin, R., Haines, J. L., Pericak-Vance, M. A., Ivinson, A. J., Stewart, G., Hafler, D. A., Hauser, S. L., Compston, A., Mcvean, G., De jager, P., Sawcer, S. J., Mccauley, J. L., Rich, S. S., Graham, R. R., Gaffney, P. M., Langefeld, C. D., Vyse, T. J., Hafler, D. A., Chun, S., Sunyaev, S. R. & Cotsapas, C., May 2024, In: Nature Genetics. 56, 5, p. 838-845 8 p.

      Research output: Contribution to journal › Article › peer-review

      29 Citations (Scopus)
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