King's College London

Research portal

Professor Toby Lawrence

  1. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

    Etzerodt, A., Moulin, M., Doktor, T. K., Delfini, M., Mossadegh-Keller, N., Bajenoff, M., Sieweke, M. H., Moestrup, S. K., Auphan-Anezin, N. & Lawrence, T., 6 Apr 2020, In : The Journal of experimental medicine. 217, 4, e20191869.

    Research output: Contribution to journalArticle

  2. Targeting stat3 and stat5 in tumor-associated immune cells to improve immunotherapy

    Verdeil, G., Lawrence, T., Schmitt-Verhulst, A. M. & Auphan-Anezin, N., 1 Dec 2019, In : Cancers. 11, 12, 1832.

    Research output: Contribution to journalArticle

  3. Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression

    Etzerodt, A., Tsalkitzi, K., Maniecki, M., Damsky, W., Delfini, M., Baudoin, E., Moulin, M., Bosenberg, M., Graversen, J. H., Auphan-Anezin, N., Moestrup, S. K. & Lawrence, T., 7 Oct 2019, In : The Journal of experimental medicine. 216, 10, p. 2394-2411 18 p.

    Research output: Contribution to journalArticle

  4. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

    Goossens, P., Rodriguez-Vita, J., Etzerodt, A., Masse, M., Rastoin, O., Gouirand, V., Ulas, T., Papantonopoulou, O., Van Eck, M., Auphan-Anezin, N., Bebien, M., Verthuy, C., Vu Manh, T. P., Turner, M., Dalod, M., Schultze, J. L. & Lawrence, T., 4 Jun 2019, In : CELL METABOLISM. 29, 6, p. 1376-1389.e4

    Research output: Contribution to journalArticle

  5. Precise and rapid validation of candidate gene by allele specific knockout with CRISPR/Cas9 in wild mice

    Chao, T., Liu, Z., Zhang, Y., Zhang, L., Huang, R., He, L., Gu, Y., Chen, Z., Zheng, Q., Shi, L., Zheng, W., Qi, X., Kong, E., Zhang, Z., Lawrence, T., Liang, Y. & Lu, L., 1 Jan 2019, In : Frontiers in Genetics. 10, FEB, 124.

    Research output: Contribution to journalArticle

  6. The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis

    Huang, R., Guo, G., Lu, L., Fu, R., Luo, J., Liu, Z., Gu, Y., Yang, W., Zheng, Q., Chao, T., He, L., Wang, Y., Niu, Z., Wang, H., Lawrence, T., Malissen, M., Malissen, B., Liang, Y. & Zhang, L., 1 Jan 2019, In : Journal of Lipid Research. 60, 12, p. 2006-2019 14 p.

    Research output: Contribution to journalArticle

  7. Autophagy in dendritic cells

    Ghislat, G. & Lawrence, T., 26 Mar 2018, In : Cellular Immunology.

    Research output: Contribution to journalArticle

  8. GADD45β Loss Ablates Innate Immunosuppression in Cancer

    Verzella, D., Bennett, J., Fischietti, M., Thotakura, A. K., Recordati, C., Pasqualini, F., Capece, D., Vecchiotti, D., D'Andrea, D., Di Francesco, B., De Maglie, M., Begalli, F., Tornatore, L., Papa, S., Lawrence, T., Forbes, S. J., Sica, A., Alesse, E., Zazzeroni, F. & Franzoso, G., Mar 2018, In : Cancer Research. 78, 5, p. 1275-1292 18 p.

    Research output: Contribution to journalArticle

  9. Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

    Habbeddine, M., Verthuy, C., Rastoin, O., Chasson, L., Bebien, M., Bajenoff, M., Adriouch, S., den Haan, J. M. M., Penninger, J. M. & Lawrence, T., 28 Nov 2017, In : Cell Reports. 21, 9, p. 2515-2527 13 p.

    Research output: Contribution to journalArticle

  10. The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

    Lee, C. Y., Lai, T. Y., Tsai, M. K., Chang, Y. C., Ho, Y. H., Yu, I. S., Yeh, T. W., Chou, C. C., Lin, Y. S., Lawrence, T. & Hsu, L. C., 8 Jun 2017, In : Nat Commun. 8, 15502.

    Research output: Contribution to journalArticle

  11. Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of 'soluble CD163' in plasma

    Etzerodt, A., Berg, R. M., Plovsing, R. R., Andersen, M. N., Bebien, M., Habbeddine, M., Lawrence, T., Møller, H. J. & Moestrup, S. K., 13 Jan 2017, In : Scientific Reports. 7, 40286.

    Research output: Contribution to journalArticle

  12. High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling

    van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., Aliyev, T., Huitema, L. F. A., Tas, S. W., Wolfs, I. M. J., Kuijpers, M. J. E., Gijbels, M. J., Schalkwijk, C. G., Koonen, D. P. Y., Abdollahi-Roodsaz, S., McDaniels, K., Wang, C. C., Leitges, M., Lawrence, T., Plat, J. & 6 others, Van Eck, M., Rye, K. A., Touqui, L., de Winther, M. P. J., Biessen, E. A. L. & Donners, M. M. P. C., 10 Jan 2017, In : CELL METABOLISM. 25, 1, p. 197-207 11 p.

    Research output: Contribution to journalArticle

  13. TGFβR signalling controls CD103

    Bain, C. C., Montgomery, J., Scott, C. L., Kel, J. M., Girard-Madoux, M. J. H., Martens, L., Zangerle-Murray, T. F. P., Ober-Blöbaum, J., Lindenbergh-Kortleve, D., Samsom, J. N., Henri, S., Lawrence, T., Saeys, Y., Malissen, B., Dalod, M., Clausen, B. E. & Mowat, A. M., 2017, In : Nat Commun. 8, 1, p. 620 1 p.

    Research output: Contribution to journalArticle

  14. Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles

    Cortés, M., Sanchez-Moral, L., de Barrios, O., Fernández-Aceñero, M. J., Martínez-Campanario, M. C., Esteve-Codina, A., Darling, D. S., Győrffy, B., Lawrence, T., Dean, D. C. & Postigo, A., 2017, In : EMBO J. 36, 22, p. 3336-3355 20 p.

    Research output: Contribution to journalArticle

  15. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

    Fan, R., Toubal, A., Goñi, S., Drareni, K., Huang, Z., Alzaid, F., Ballaire, R., Ancel, P., Liang, N., Damdimopoulos, A., Hainault, I., Soprani, A., Aron-Wisnewsky, J., Foufelle, F., Lawrence, T., Gautier, J. F., Venteclef, N. & Treuter, E., 2016, In : Nature Medicine. 22, 7, p. 780-791

    Research output: Contribution to journalArticle

  16. Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

    Baratin, M., Foray, C., Demaria, O., Habbeddine, M., Pollet, E., Maurizio, J., Verthuy, C., Davanture, S., Azukizawa, H., Flores-Langarica, A., Dalod, M. & Lawrence, T., 2015, In : Immunity. 42, 4, p. 627-39

    Research output: Contribution to journalArticle

  17. Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α

    Kuijpers, M. J., Mattheij, N. J., Cipolla, L., van Geffen, J. P., Lawrence, T., Donners, M. M., Boon, L., Lievens, D., Torti, M., Noels, H., Gerdes, N., Cosemans, J. M., Lutgens, E. & Heemskerk, J. W., 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1374-81

    Research output: Contribution to journalArticle

  18. Macrophage activation and polarization: nomenclature and experimental guidelines

    Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., Locati, M., Mantovani, A., Martinez, F. O., Mege, J. L., Mosser, D. M., Natoli, G., Saeij, J. P., Schultze, J. L., Shirey, K. A., Sica, A. & 5 others, Suttles, J., Udalova, I., van Ginderachter, J. A., Vogel, S. N. & Wynn, T. A., Jul 2014, In : Immunity. 41, 1, p. 14-20 7 p.

    Research output: Contribution to journalArticle

  19. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

    Dalod, M., Chelbi, R., Malissen, B. & Lawrence, T., May 2014, In : EMBO J. 33, 10, p. 1104-1116

    Research output: Contribution to journalArticle

  20. Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice

    Tilstam, P. V., Gijbels, M. J., Habbeddine, M., Cudejko, C., Asare, Y., Theelen, W., Zhou, B., Döring, Y., Drechsler, M., Pawig, L., Simsekyilmaz, S., Koenen, R. R., de Winther, M. P., Lawrence, T., Bernhagen, J., Zernecke, A., Weber, C. & Noels, H., 3 Feb 2014, In : PL o S One . 9, 2, 15 p., e87452.

    Research output: Contribution to journalArticle

  21. An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

    Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P., 2014, In : Biochem J. 461, 3, p. 531-537

    Research output: Contribution to journalArticle

  22. Cigarette smoke induced airway inflammation is independent of NF-κB signalling

    Rastrick, J. M., Stevenson, C. S., Eltom, S., Grace, M., Davies, M., Kilty, I., Evans, S. M., Pasparakis, M., Catley, M. C., Lawrence, T., Adcock, I. M., Belvisi, M. G. & Birrell, M. A., 2013, In : PL o S One . 8, 1, p. e54128

    Research output: Contribution to journalArticle

  23. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection

    Mancino, A., Habbeddine, M., Johnson, E., Luron, L., Bebien, M., Memet, S., Fong, C., Bajenoff, M., Wu, X., Karin, M., Caamano, J., Chi, H., Seed, M. & Lawrence, T., 2013, In : EMBO J. 32, 6, p. 816-28

    Research output: Contribution to journalArticle

  24. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity

    Bebien, M., Hensler, M. E., Davanture, S., Hsu, L. C., Karin, M., Park, J. M., Alexopoulou, L., Liu, G. Y., Nizet, V. & Lawrence, T., 2012, In : PL o S Pathogens. 8, 7, p. e1002812

    Research output: Contribution to journalArticle

  25. Macrophages and NF-κB in cancer

    Lawrence, T., 2011, In : Current Topics in Microbiology and Immunology. 349, p. 171-84

    Research output: Contribution to journalArticle

  26. Transcriptional regulation of macrophage polarization: enabling diversity with identity

    Lawrence, T. & Natoli, G., 2011, In : NATURE REVIEWS IMMUNOLOGY. 11, 11, p. 750-61

    Research output: Contribution to journalArticle

  27. Nuclear factor-kappaB and tumor-associated macrophages

    Mancino, A. & Lawrence, T., 2010, In : Clinical Cancer Research. 16, 3, p. 784-9

    Research output: Contribution to journalArticle

  28. The resolution of inflammation and cancer

    Rodriguez-Vita, J. & Lawrence, T., 2010, In : Cytokine and Growth Factor Reviews. 21, 1, p. 61-5

    Research output: Contribution to journalArticle

  29. The resolution of inflammation: anti-inflammatory roles for NF-kappaB

    Lawrence, T. & Fong, C., 2010, In : The international journal of biochemistry & cell biology. 42, 4, p. 519-23

    Research output: Contribution to journalArticle

  30. Investigating macrophage and malignant cell interactions in vitro

    Hagemann, T. & Lawrence, T., 2009, In : Methods in Molecular Biology. 512, p. 325-32

    Research output: Contribution to journalArticle

  31. Regulation of macrophage function in tumors: the multifaceted role of NF-kappaB

    Hagemann, T., Biswas, S. K., Lawrence, T., Sica, A. & Lewis, C. E., 2009, In : Blood. 113, 14, p. 3139-46

    Research output: Contribution to journalArticle

  32. The nuclear factor NF-kappaB pathway in inflammation

    Lawrence, T., 2009, In : Cold Spring Harbor Laboratory Press. 1, 6, p. a001651

    Research output: Contribution to journalArticle

  33. The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans

    Charles, K. A., Kulbe, H., Soper, R., Escorcio-Correia, M., Lawrence, T., Schultheis, A., Chakravarty, P., Thompson, R. G., Kollias, G., Smyth, J. F., Balkwill, F. R. & Hagemann, T., 2009, In : Journal of Clinical Investigation. 119, 10, p. 3011-23

    Research output: Contribution to journalArticle

  34. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

    Kim, C., Sano, Y., Todorova, K., Carlson, B. A., Arpa, L., Celada, A., Lawrence, T., Otsu, K., Brissette, J. L., Arthur, J. S. C. & Park, J. M., Sep 2008, In : Nature Immunology. 9, 9, p. 1019-1027 9 p.

    Research output: Contribution to journalArticle

  35. "Re-educating" tumor-associated macrophages by targeting NF-kappaB

    Hagemann, T., Lawrence, T., McNeish, I., Charles, K. A., Kulbe, H., Thompson, R. G., Robinson, S. C. & Balkwill, F. R., 2008, In : The Journal of experimental medicine. 205, 6, p. 1261-8

    Research output: Contribution to journalArticle

  36. 'Re-educating' macrophages in infection and cancer by targeting NF-kappa B

    Lawrence, T., Fong, C. & Hagemann, T., 2008, In : Cytokine. 43, 3, p. 271-271

    Research output: Contribution to journalArticle

  37. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation

    Fong, C. H., Bebien, M., Didierlaurent, A., Nebauer, R., Hussell, T., Broide, D., Karin, M. & Lawrence, T., 2008, In : Journal of Experimental Medicine. 205, 6, p. 1269-76

    Research output: Contribution to journalArticle

  38. Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung

    Zhang, M., Qian, J., Xing, X., Kong, F. M., Zhao, L., Chen, M. & Lawrence, T. S., 2008, In : Clinical Cancer Research. 14, 6, p. 1868-76

    Research output: Contribution to journalArticle

  39. Novel biphasic role for lymphocytes revealed during resolving inflammation

    Rajakariar, R., Lawrence, T., Bystrom, J., Hilliard, M., Colville-Nash, P., Bellingan, G., Fitzgerald, D., Yaqoob, M. M. & Gilroy, D. W., 2008, In : Blood. 111, 8, p. 4184-92

    Research output: Contribution to journalArticle

  40. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection

    Didierlaurent, A., Goulding, J., Patel, S., Snelgrove, R., Low, L., Bebien, M., Lawrence, T., van Rijt, L. S., Lambrecht, B. N., Sirard, J. C. & Hussell, T., 2008, In : The Journal of experimental medicine. 205, 2, p. 323-9

    Research output: Contribution to journalArticle

  41. Cancer. Sex, cytokines, and cancer

    Lawrence, T., Hageman, T. & Balkwill, F., 2007, In : Science (New York, N.Y.). 317, 5834, p. 51-2

    Research output: Contribution to journalArticle

  42. Chronic inflammation: a failure of resolution?

    Lawrence, T. & Gilroy, D. W., 2007, In : International Journal of Experimental Pathology. 88, 2, p. 85-94 10 p.

    Research output: Contribution to journalArticle

  43. Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2

    Rajakariar, R., Hilliard, M., Lawrence, T., Trivedi, S., Colville-Nash, P., Bellingan, G., Fitzgerald, D., Yaqoob, M. M. & Gilroy, D. W., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20979-84

    Research output: Contribution to journalArticle

  44. IKKalpha in the regulation of inflammation and adaptive immunity

    Lawrence, T. & Bebien, M., 2007, In : Biochemical Society Transactions. 35, Pt 2, p. 270-2

    Research output: Contribution to journalArticle

  45. IKKbeta inhibits 'Classical' macrophage activation in innate immunity and cancer

    Lawrence, T., Fong, C., Bebien, M., Karin, M., Balkwill, F. & Hagemann, T., 2007, In : Journal of Leukocyte Biology. p. 41-41

    Research output: Contribution to journalArticle

  46. Inflammation and cancer: a double-edged sword

    Hagemann, T., Balkwill, F. & Lawrence, T., 2007, In : CANCER CELL. 12, 4, p. 300-1

    Research output: Contribution to journalArticle

  47. Inflammation and cancer: a failure of resolution?

    Lawrence, T., 2007, In : Trends in Pharmacological Sciences. 28, 4, p. 162-5

    Research output: Contribution to journalArticle

  48. TNFalpha signalling inhibits 'classical' macrophage activation

    Fong, C. H. & Lawrence, T., 2007, In : Journal of Leukocyte Biology. p. 45-45

    Research output: Contribution to journalArticle

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