Toby Prevost was appointed in 2020 to the newly created Nightingale-Saunders Chair of Complex Clinical Trials and Statistics, King's College London within the Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care.

He is the Director of the Nightingale-Saunders Clinical Trials and Epidemiology Unit, established in May 2020, which is a specialist faculty-based section of the King's Clinical Trials Unit, involved in the funding application for, and delivery of, national and international studies, and in the development of an educational clinical trials programme in the Faculty:

https://www.kcl.ac.uk/nmpc/research/clinical-trials-unit

Toby was preceding this (2016-2020) a Chair in Clinical Trials and Medical Statistics at Imperial College London, and as Head of Statistics in the Imperial Clinical Trials Unit. From 2018 he was Director of the Imperial Statistical Advisory Service. He was an Honorary Visiting Professor at Imperial College London (2020-2023).

Prior to this, Toby was appointed to a Readership post at King's College London in 2009, within the Primary Care and Public Health Sciences Division, Faculty of Life Sciences and Medicine. He was the Deputy Director of the newly formed Unit for Medical Statistics, engaged in clinical trials and statistical consulting for the design of medical research studies.

In 2012, Toby was promoted, at King's College London, to Professor of Medical Statistics. His inaugural lecture summarises his collaborative research to this point, largely in the planning, delivery and evaluation of complex and lifestyle health interventions in clinical trials of behavioural and clinical outcomes in diabetes and related conditions.

https://www.youtube.com/watch?v=3K8U0Vbr2zs

Before this he was a Senior Medical Statistician (2002-2009) and Medical Statistician (1991-1993 and 1996-2002), principally involved in clinical trials, developing interests in cluster randomised trials, trial design, complex intervention trials, and statistical consulting, in the Department of Public Health and Primary Care at the University of Cambridge, across the Primary Care Unit and the Centre for Applied Medical Statistics.

He was seconded to a Senior Research Scientist post (2002-2006) in the Cambridge MRC Biostatistics Unit led by Professor Simon Thomson, via an MRC Group Cooperative grant for complex interventions in primary care led by Ann-Louise Kinmonth, the Foundation Professor of General Practice at the University of Cambridge.

This MRC grant allowed him to develop two areas of methodological interests in collaboration with other statisticians:

- with Professor Simon Thompson and Dr Rebecca Turner --- in designing cluster randomised trials with greater certainty of the statistical power to detect intervention effects. 

- with Professor David Spiegelhalter --- in multivariate meta-analysis of correlations between constructs (variables) in order to understand the basis of, and support for the Theory of Planned Behaviour, which was assumption underlying many of the developed complex interventions intending to change lifestyle behaviours, such as physical activity.

Toby set up a related Statistical Modelling Group within the University's Primary Care Unit undertaking primary care trials, and statistical research via a PhD studentship. This extended causal inference methods from the standard univariate (one outcome variable at a time) method to a multivariate approach (combine several related outcomes together), thereby strengthening the information to be able to then understand which components of a complex intervention may have led to the randomised result.

Toby studied at the University of Southampton, completing a BSc in Mathematics with Statistics (1990), MSc in Statistics with Applications in Medicine (1991), and PhD in Social Statistics (1996) comparing a Bayesian approach to traditional approaches to the multilevel analysis of binary child mortality outcome data which clusters in families and is associated with short birth spacing, using data from the 1988 Tunisian Demographic and Health Survey.

In between his MSc and PhD, Toby was the statisticial member of the 7-year longitudinal follow-up of the nationwide Health and Lifestyle Survey, giving early experience of working in a multidiciplinary research team which included a nutritionist, physiologist, sociologist, psychologist, psychiatrist and data manager.

Toby has served on national committees drawing on his interests in research design and evidence synthesis and its interpretation - the combination (meta-analysis) of published research evidence:

the NICE Public Health Interventions Advisory Committee (2008-2013); the NICE Public Health Advisory Committee (2013-2020); as Expert Panel Member of the SACN (Scientific Advisory Committee on Nutrition) with NICE Rapid Guideline for Vitamin D and Covid-19 (2020); the NIHR Public Health Research Funding Committee (2014-2020); the NIHR Covid-19 Recovery and Learning Funding Committee (2020); a Cancer Research UK Prevention & Population Expert Review Panel (2021); on a European Funding Board for sub-macular haemorrhage for EURETINA/Fight for Sight; and as an NIHR Public Health Research Applications and Design Advisor (2020-2023)

Regionally, he has contributed as a London Research Design Service advisor (2011-2015 and 2022-2023); an Independent Advisory Board member on the NIHR Central-region PHIRST (Public Health Interventions Responsive Studies Team) led by the University of Hertfordshire; and on committees as an independent member overseeing >30 clinical trials around the country.

He has experience in complex interventions trials, including primary care prevention trials of interventions to support change in lifestyle behaviours such as physical activity (preventive of Type 2 diabetes) and smoking cessation, and medication adhererence, and complex interventions for improving breathlessness in palliative care.

His experience in clinical treatment trials is broad though with a focus of application within ophthalmology, rheumatology, diabetes, prevention of weight gain, and, within palliative care: breathlessness, rehabilitation and cancer management.

He also has some experience in early phase trials, including Phase I to II dose-finding trials that are 'adaptive', in learning as they go along and being able to be more efficient in establishing safe doses, with the involvement of fewer patients.

He has been involved a wide range of research collaborations, leading to 200 published co-authored research papers, with a Scopus H-Index of 56 (this being the number of these publications that have been cited at least this same number of times).

 https://www.scopus.com/authid/detail.uri?authorId=7004917424

This is a selection of research collaborations (with statisticial co-workers shown in bold):

Palliative Care and Nurse-led Research

PrimaryBreathe: programme to develop and test a brief remote primary care intervention for chronic breathlessness. Principal Investigator (PI): Anna Spathis (Cambridge). NIHR Programme Grants for Applied Research £2.4M (1/9/22; 60m) - a cluster randomised trial.

PAM: Randomised controlled trial of a very brief nurse-led intervention followed by a text message or a smartphone app to support medication adherence in people prescribed treatment for hypertension in primary care. PI: Stephen Sutton (Cambridge) NIHR Programme Grants for Applied Research £2M (1/6/2017; 60 months)

INSPIRE: INtegrated Short-term PallIative REhabilitation to improve quality of life and equitable care access in incurable cancer. PI: Matt Maddocks (KCL). EU Horizon and UKRI £3.8M (1/9/22; 48m)

NIHR Global Health Research Group On Global Health And Palliative Care (GHAP): Expanding Access. PI: Richard Harding (KCL), £2.7m (1/2/22; 48m).

NIHR Research for Patient Benefit funded, £250k. PI: Morag Farquhar. Two trials with authors: Farquhar M, Prevost AT, McCrone P, Brafman-Price B, Bentley A, Higginson IJ, Todd C, Booth S.

(1) The clinical and cost-effectiveness of a Breathlessness Intervention Service for patients with advanced non-malignant disease and their informal carers - mixed findings of a mixed method randomised controlled trial. Trials 2016 Apr;17:185.

(2) Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial.  BMC Medicine. 2014;12:194.

Farmer A, Hardeman W, Hughes D, Prevost AT, Kim Y, Craven A, Oke J, Boase S, Selwood M, Kellar I, Graffy J, Griffin S, Sutton S, Kinmonth AL. An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes. BMC Family Practice 2012;13:30. MRC funded. Co-PIs: Ann-Louise Kinmonth and Andrew Farmer

Gelling L, Prevost AT. The needs of relatives of critically ill patients admitted to a neurosciences critical care unit: A comparison of the perceptions of relatives, nurses and doctors. Care of the Critically Ill 1999;15:53-58

India and UK Diabetic Retinopathy Collaboration. PI: Sobha Sivaprasad. RCUK(MRC) funded

Raman R, Vasconcelos JC, Rajalakshmi R, Prevost AT, Ramasamy,  Mohan KV, Mohan D, Rani PK, Conroy D, Das T, Sivaprasad S. Prevalence of diabetes retinopathy in India stratified by known and undiagnosed diabetes, unban and rural locations, and socio-economic indices: results from the SMART India population-based cross-sectional screening study. Lancet Global Health 2022 Dec;10(12):e1764-e1773 doi: 10.1016/S2214-109X(22)00411-9.

Rajalakshmi R, Vasconcelos JC, Prevost AT, Sivaprasad S, Deepa M, Raman R,  Ramasamy K, Anjana RM, Conroy D, Das T, Hanif W, Mohan KV, Mohan V.  Burden of undiagnosed and sub-optimally controlled diabetes in selected regions of India: Results from the SMART India population-level diabetes screening study. Diabetic Medicine 2023 Jun 12:e15165

Nugawela MD, Gurudas S, Prevost AT, Mathur R, Robson J, Sathish T, Rafferty JM, Rajalakshmi R, Anjana RM, Jebarani S, Mohan V, Owens DR, Sivaprasad S. Development and validation of predictive risk models for sight threatening diabetic retinopathy in patients with type 2 diabetes to be applied as triage tools in resource limited settings. EClinicalMedicine 2022;51:101578.

Gurudas S, Maheshwari JJ, Revathy YR, Frudd K, Sivaprasad S, Ramanathan SM, Pooleeswaran V, Prevost AT, Karatsai E, Halim S, Chandra S, Nderitu P, Conroy D, Krishnakumar S, Parameswaran S, Dharmalingam K, Ramasamy K, Raman R, Jones C, Eleftheriadis H, Greenwood J, Turowski P. Multicentre Evaluation of diagnostic circulating biomarkers to detect sight-threatening diabetic retinopathy. JAMA Ophthalmology 2022; May 5:e221175.

Gurudas S, Nugawela M, Prevost AT, Sathish T, Mathur R, Rafferty JM, Blighe K, Rajalakshmi R, Mohan AR, Saravanan J, Majeed A, Mohan V, Owens DR, Robson J, Sivaprasad S. Development and validation of resource-driven risk prediction models for incident chronic kidney disease in type 2 diabetes. Scientific Reports 2021;11:13654

Other Ophthalmology Research

PINNACLE: Deciphering AMD by deep phenotyping and machine learning. PI: Andrew Lotery (Southampton) Wellcome Trust Collaborative Award in Science. Involvement in the prospective cohort study with statistical prediction modelling element.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group. Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial. JAMA Ophthalmology 2019 Aug 29. NIHR HTA funded. PI: Phil Hykin. King's CTU

Sivaprasad S, Vasconcelos JC, Prevost AT, Holmes H, Hykin P, George S, Murphy C, Kelly J, Arden GB. Clinical efficacy and safety of a light mask for prevention of dark adaption in treating and preventing progression of early diabetic macular oedema at 24 months (CLEOPATRA): a multicentre, phase 3, randomised controlled trial. Lancet Diabetes & Endocrinology 2018;6:382-391. NIHR/MRC EME funded. PI: Sobha Sivaprasad. King's CTU

Sivaprasad S, Prevost AT, Vasconcelos JC, Riddell A, Murphy C, Kelly J, Bainbridge J, Tudor-Edwards R, Hopkins D, Hykin P. Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial. The Lancet 2017;389:2193-2203. NIHR/MRC EME funded. PI: Sobha Sivaprasad. King's CTU

This research paper was selected as a finalist for the 2018 BMJ Awards Research Paper of the Year (final 6).

Rheumatology Trials and Methods Research

ALTO: Arthritis prevention in the pre-clinical phase of RA with Abatacept – Long Term Outcome Study. PI: Andrew Cope (KCL) Bristol-Myers Squibb

Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D’Agostino M-A, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP. Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double blind, parallel-group, placebo-controlled clinical trial protocol. Trials 2019;20:429. Bristol-Myers Squibb funded. PI: Andrew Cope. King's CTU.

Ibrahim F, Tom BDM, Scott DL, Prevost AT. Characterization of missing data patterns and mechanisms in longitudinal composite outcome trial in Rheumatoid Arthritis. Ther Adv Musculoskelet Dis. 2022;14:1759720X221114103

Ibrahim F, Tom BDM, Scott DL, Prevost AT. A systematic review of randomised controlled trials in rheumatoid arthritis: the reporting and handling of missing data in composite outcomes. Trials 2016 Jun;17(1):272. PhD Studentship.

Kirkham B, Chaabo K, Hall C, Garrood T, Mant T, Allen E, Vincent A, Vasconcelos JC, Prevost AT, Panayi GS, Corrigall VM. Safety and patient response as indicated by biomarker changes to BiP in the Phase I/IIa RAGULA clinical trial in rheumatoid arthritis. Rheumatology 2016 Nov;55(11):1993-2000.

Methods research for clustered data and Cluster Randomised Trials in various research areas

Turner RM, Prevost AT, Thompson SG. Allowing for imprecision of the intracluster correlation coefficient in the design of cluster randomised trials. Statistics in Medicine 2004;23:1195-1214

Prevost AT. PhD in Social Statistics: Multilevel Modelling of child mortality (1996) comparing Bayesian and Classical methods for analysing clustered binary outcome data. University of Southampton PhD thesis abstract: https://eprints.soton.ac.uk/460252/

Jawad S, Modi N, Prevost AT, Gale C. A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data. Trials 2019;20:731

Simmons RK, Echouffo-Tcheugui JB, Sharp SJ, Sargeant LA, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ . Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. The Lancet 2012;380(9855):1741-8. PIs: Ann-Louise Kinmonth, Nick Wareham, Simon Griffin

This research paper won the title of 2013 BMJ Awards Research Paper of the Year, and was awarded Diabetes Paper of the Year 2012 by the Royal College of Practitioners.

Paddison CAM, Eborall HC, Sutton S, French DP, Vasconcelos J, Prevost AT, Kinmonth AL, Griffin SJ. Are people with negative diabetes screening tests falsely reassured?  A parallel group cohort study embedded in the ADDITION (Cambridge) randomised controlled trial. BMJ 2009;339:b4535. PI: Stephen Sutton

Eborall HC, Griffin SJ, Prevost AT, Kinmonth AL, French DP, Sutton S. Psychological Impact of Screening for Type 2 Diabetes: Controlled Trial and Comparative Study Embedded in the ADDITION (Cambridge) Randomised Controlled trial. BMJ 2007;335:486. PI: Stephen Sutton

Emery J, Morris H, Goodchild R, Fanshawe T, Prevost AT, Bobrow M, Kinmonth AL. The GRAIDS Trial: a cluster randomised controlled trial of computer decision support for the management of familial cancer risk in primary care. British Journal of Cancer 2007;97:486-493. CRUK funded. PI: Jon Emery.

Cancer Diagnosis in Primary Care

Walter FM, Morris HC, Humphrys E, Hall PN, Prevost AT, Burrows N, Bradshaw L, Wilson EC, Norris P, Walls J, Johnson M, Kinmonth AL, Emery JD. Effect of adding a diagnostic aid to best practice to manage suspicious pigmented lesions in primary care: randomised controlled trial. BMJ 2012;345:e4110

This research paper was awarded Cancer Paper of the Year 2012 by the Royal College of Practitioners.

Complex Intervention Trials, Fidelity of delivery, and Methods Research

Kinmonth AL, Wareham NJ, Hardeman W, Sutton S, Prevost AT, Fanshawe T, Williams K, Ekelund U, Spiegelhalter D, Griffin SJ. Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trial. The Lancet 2008;371:41-48

Lancaster GA, Campbell MJ, Eldridge S, Farrin A, Marchant M, Muller S, Perera R, Peters TJ, Prevost AT, Rait G. Trials in Primary Care: statistical  issues in the design, conduct and evaluation of complex interventions. Statistical Methods in Medical Research 2010;19:349-77

Michie S, Hardeman W, Fanshawe T, Prevost AT, Taylor L, Kinmonth AL. Investigating theoretical explanations for behaviour change: The case study of ProActive. Psychology and Health 2008;23:25-39

Hardeman W, Michie S, Fanshawe T, Prevost AT, Mcloughlin K, Kinmonth AL. Fidelity of delivery of a physical activity intervention: Predictors and consequences. Psychology and Health 2008;23:11-24

Griffin SJ, Simmons RK, Prevost AT, Williams KM, Hardeman W, Sutton S, Brage S, Ekelund U, Parker RA, Wareham NJ, Kinmonth AL; on behalf of the ADDITION-Plus study team. Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes: the ADDITION-Plus randomised controlled trial. Diabetologia 2014;57:1308-19

Trials involving psychology

Hollands GJ, Whitwell SC, Parker RA, Prescott NJ, Forbes A, Sanderson J, Mathew CG, Lewis CM, Watts S, Sutton S, Armstrong D, Kinmonth AL, Prevost AT, Marteau TM. Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial. BMJ 2012;345:e4708.

Marteau TM, Mann E, Prevost AT, Vasconcelos JC, Kellar I, Sanderson S, Parker M, Griffin S, Sutton S, Kinmonth AL. Impact of an informed choice invitation on uptake of screening for diabetes in primary care (DICISION): a randomised trial. BMJ 2010;340:c2138

Adaptive and staged studies

TRIBUTE: Feasibility for Targeted Regulatory T Cell Therapy for Inflammatory Bowel Disease. Phase I/II Adaptive dose-finding trial. PI: Graham Lord (KCL) MRC DPFS funded

An Open-label, Phase I/II Dose Escalation Trial of a Photoreceptor Transplantation in Adults with Cone Dystrophy. PI: Robin Ali (KCL). MRC DPFS

Prevost AT. A journey from statistical consultation to funded adaptive trial.  Trials 2017;18(Suppl 1):P108

Prevost AT, Bowden J. Designing a preliminary adaptive study to inform a biomarker trial in Psoriasis. Trials 2011;12(S1):A17

Robertson D, Prevost AT, Bowden J. Accounting for selection and correlation in the analysis of two-stage genome-wide association studies. Biostatistics 2016 Oct;17(4):634-49

Robertson D, Prevost AT, Bowden J. Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules. Statistics in Medicine 2016; Sep;35(22):3907-22

Robertson D, Prevost AT, Bowden J. Correcting for bias in the selection and validation of informative diagnostic tests. Statistics in Medicine 2015 Apr 15;34(8):1417-37

Causal Mediation

Casey N, Thompson S, Prevost AT. Modelling multiple outcomes to improve the detection of causal mediation effects in complex intervention trials. Trials 2011;12(S1):O

Application and Development of Meta-analysis methods in health research

Prevost AT, Mason D, Griffin S, Kinmonth AL, Sutton S, Spiegelhalter D. Allowing for correlations between correlations in random-effects meta-analysis of correlation matrices. Psychological Methods 2007;12:434-50

Vasconcelos J, Turner R, Prevost AT. Assessing the impact of an omitted study on the overall meta-analysis estimate. Trials 2017;18(Suppl 1):O60

Naughton F, Prevost AT, Sutton S. Self-help smoking cessation interventions in pregnancy - a systematic review and meta-analysis. Addiction 2008;103:566-79

Braithwaite D, Emery J, Walter F, Prevost AT, Sutton S. Psychological impact of genetic counseling for familial cancer: a systematic review and meta-analysis. Journal of the National Cancer Institute 2004;96:122-133.

Clinical Trial research using Electronic Records

Jawad S, Modi N, Prevost AT, Gale C. A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data. Trials 2019;20:731. Imperial PhD studentship.

Gulliford M, Prevost AT, Clegg A, Rezel-Potts E. Mortality of care home residents and community-dwelling controls during the COVID-19 pandemic in 2020: matched cohort study. J Am Med Dir Assoc. 2022 Jun;23(6):923-929.e2

Gulliford MC, Prevost AT, Charlton J, Juszczyk D, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay A, Little P, Moore MV, Yardley L, Ashworth M. Effectiveness and safety of electronically-delivered prescribing feedback and decision support on antibiotic utilization for respiratory illness in primary care. BMJ 2019;364:I236. NIHR HTA funded.

Digital adaptive intervention with University of East Anglia

Naughton F, Hope A, Siegele-Brown C, Grant K, Barton G, Notley C, Mascolo C, Coleman T, Shepstone L, Sutton S, Prevost AT, Crane D, Greaves F, High J. An automated, online feasibility randomised controlled trial of a just-in-time adaptive intervention for smoking cessation (Quit Sense). Nicotine Tob Res 2023 Apr 14;ntad032 doi: 10.1093/ntr/ntad032. NIHR Public Health Research funded PI: Felix Naughton.

Imperial College London Collaborations

iPREVENT: Increase colonic propionate as a method of preventing weight gain in young adults (RCT). PI: Gary Frost (Imperial) NIHR/MRC EME

Rockall AG, Li X, Johnson N, Lavdas I, Santhakumaran S, Prevost AT, Punwani S, Goh V, Barwick T, Bharwani N, Sandhu A, Sidhu H, Plumb A, Burn J, Fagan A, Wengert GJ, Koh D-M, Reczko K, Qi S, Warwick J, Liu X, Messiou C, Tunariu N, Boavida P, Soneji N, Johnston EW, Kelly-Morland C, De Paepae K, Sokhi H, Wallitt K, Lakshani A, Russell J, Salib M, Vinnicombe S, Haq A, Aboagye E, Stuart T, Glocker B. Development and evaluation of machine learning in whole-body magnetic resonance imaging for detecting metastases in patients with lung or colon cancer: a diagnostic t. est accuracy study. Investigative Radiology 2023; June 26

Tan T, Khoo B, Mills EG, Phylactou M, Patel B, Eng PC, Thurston L, Muzi B, Meeran K, Prevost AT, Comninos AN, Abbara A, Dhillo WS. Association between high serum total cortisol concentrations and mortality from COVID-19. Lancet Diabetes & Endocrinology 2020;8:659-60

Santhakumaran S, Gordon A, Prevost AT, O'Kane C, McAuley DF, Shankar-Hari M. Heterogeneity of Treatment Effect by Baseline Risk of Mortality in Critically Ill Patients: Re-analysis of three recent Sepsis and ARDS Randomised Controlled Trials. Critical Care 2019;23(1):156. NIHR/MRC EME funded.

Kenkre JS, Ahmed AR, Purkayastha S, Malallah K, Bloom S, Blakemore A, Prevost AT, Tan T. Who will benefit from bariatric surgery for diabetes? A protocol for an observational cohort study. BMJ Open 2021 Feb 10;11(2):e042355. NIHR Doctoral Fellowship funded.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S,  Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM. Combined GLP-1, oxyntomodulin and peptide YY improves body weight and glycaemia in obesity and prediabetes/type 2 diabetes: a randomized single-blinded placebo controlled study. Diabetes Care 2019;42(8):1446-53

Cambridge (University and NHS Trust) Primary and Secondary Care Collaborations

Hardeman W, Mitchell J, Pears S, Van Emmenis M, Theil F, GC VS, Vasconcelos JC, Westgate K, Brage S, Suhrcke M, Griffin S, Kinmonth AL, Wilson ECF, Prevost AT, Sutton S. Evaluation of a very brief pedometer-based physical activity intervention delivered in NHS Health Checks: The VBI randomised controlled trial. Plos Medicine 2020; Mar 6;17(3):e1003046. NIHR Programme Grants for Applied Research funded.

Naughton F, Jamison J, Boase S, Sloan M, Gilbert H, Prevost AT, Mason D, Smith S, Brimicombe J, Evans R, Sutton S. Randomized controlled trial to assess the short-term effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care (iQuit in Practice). Addiction 2014;109:1184-93. Cancer Research UK funded.

Simmons RK, Echouffo-Tcheugui JB, Sharp SJ, Sargeant LA, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ . Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. The Lancet 2012;380(9855):1741-8 (role principally in the trial design and conduct stages) Wellcome Trust and NIHR funded.

Walter FM, Morris HC, Humphrys E, Hall PN, Prevost AT, Burrows N, Bradshaw L, Wilson EC, Norris P, Walls J, Johnson M, Kinmonth AL, Emery JD. Effect of adding a diagnostic aid to best practice to manage suspicious pigmented lesions in primary care: randomised controlled trial. BMJ 2012;345:e4110. NIHR School for Primary Care Research funded.

Corrie PG, Moody AM, Armstrong G, Nolasco S, Lao-Sirieix S-H, Bavister L, Prevost AT, Parker R, Sabes-Figuera R, McCrone P, Balsdon H, McKinnon K, Hounsell A, O’Sullivan B, Barclay S. Is community treatment best? A randomised trial comparing delivery of cancer treatment in the hospital, home and GP surgery. British Journal of Cancer 2013;109:1549-55. NIHR RfPB funded. NIHR Research for Patient Benefit funded.

Hollands GJ, Whitwell SC, Parker RA, Prescott NJ, Forbes A, Sanderson J, Mathew CG, Lewis CM, Watts S, Sutton S, Armstrong D, Kinmonth AL, Prevost AT, Marteau TM. Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial. BMJ 2012;345:e4708. Wellcome Trust funded.

Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, Robson W, Leung HY, Vasdev N, Pickard RS, Williams GH, Stoeber K. Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of mcm5 and nuclear matrix protein 22. PLoS One 2012;7:e40305. Cancer Research UK funded.