Search results

• 2012

  Allele-Specific Cytokine Responses at the HLA-C Locus: Implications for Psoriasis

  Hundhausen, C., Bertoni, A., Mak, R. K., Botti, E., Di Meglio, P., Clop, A., Laggner, U., Chimenti, S., Hayday, A. C., Barker, J. N., Trembath, R. C., Capon, F. & Nestle, F. O., Mar 2012, In: Journal of Investigative Dermatology. 132, 3, p. 635 - 641 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytokine Response 100%
  • Allele 100%
  • HLA-C 100%
  • Tumor Necrosis Factor Alpha 75%
  • Tumor Necrosis Factor 50%
  24 Citations (Scopus)
• 2011

  Identification of a novel pro-inflammatory human skin-homing V gamma 9V delta 2 T cell subset and its role in the pathogenesis of psoriasis

  Laggner, U., Di Meglio, P., Perea, G. K., Hundhausen, C., Lacy, K. E., Ali, N., Smith, C. H., Hayday, A. C., Nickoloff, B. J. & Nestle, F. O., 2011, In: Journal of Investigative Dermatology. 131, p. S1 - S1

  Research output: Contribution to journal › Meeting abstract

• Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis

  Laggner, U., Di Meglio, P., Perera, G. K., Hundhausen, C., Lacy, K. E., Ali, N., Smith, C. H., Hayday, A. C., Nickoloff, B. J. & Nestle, F. O., 1 Sept 2011, In: Journal of Immunology. 187, 5, p. 2783-2793 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Tissue Reaction 100%
  291 Citations (Scopus)

• The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

  Di Meglio, P., Di Cesare, A., Laggner, U., Chu, C.-C., Napolitano, L., Villanova, F., Tosi, I., Capon, F., Trembath, R. C., Peris, K. & Nestle, F. O., 2011, In: PL o S One . 6, 2, e17160.

  Research output: Contribution to journal › Article › peer-review

  • Allele 100%
  • Th17 Cell 100%
  • Genome-Wide Association Study 33%
  • Cellular Differentiation 33%
  • Cytokine 33%
  232 Citations (Scopus)

• The IL23R R381Q gene variant protects against psoriasis by impairing IL-23-induced STAT-3 phosphorylation and IL-17A production in human Th17 cells

  Di Meglio, P., Di Cesare, A., Laggner, U., Chu, C.-C., Napolitano, L., Villanova, F., Tosi, I., Capon, F., Trembath, R. C., Peris, K. & Nestle, F. O., 2011, In: British Journal of Dermatology. 164, 4, p. 918 - 919 2 p.

  Research output: Contribution to journal › Meeting abstract
• 2010

  Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

  Tonel, G., Conrad, C., Laggner, U., Di Meglio, P., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J.-Z., Xin, H., Oldham, E., Kastelein, R., Nickoloff, B. J. & Nestle, F. O., 15 Nov 2010, In: Journal of Immunology. 185, 10, p. 5688 - 5691 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Effector Cell 100%
  • Inflammatory Disorder 100%
  • Tumor Necrosis Factor 100%
  • Immunology 100%
  • Interleukin 23 100%
  198 Citations (Scopus)

• Functional analysis of the psoriasis, Crohn's disease and ankylosing spondylitis associated protective R381Q IL23R gene variant reveals impaired Th17 response in humans

  Di Meglio, P., Di Cesare, A., Laggner, U., Chu, C.-C., Napolitano, L., Villanova, F., Tosi, I., Capon, F., Trembath, R. C., Peris, K. & Nestle, F. O., 2010, In: Immunology. 131, p. 124 - 124 1 p.

  Research output: Contribution to journal › Meeting abstract

• Novel insights into expression and regulation of HLA-Cw*0602 in psoriasis

  Hundhausen, C., Bertoni, A., Mak, R. K., Botti, E., Laggner, U., Marget, M., Capon, F., Trembath, R. & Nestle, F. O., 2010, In: Immunology. 131, p. 110 - 110 1 p.

  Research output: Contribution to journal › Meeting abstract

• The role of V gamma 9V delta 2 gamma delta T cells in malignant melanoma

  Laggner, U., Harries, M., Hayday, A., Nestle, F. & Lacy, K., 2010, In: British Journal of Dermatology. 162, 4, p. 924 - 924 1 p.

  Research output: Contribution to journal › Meeting abstract
• 2009

  A Gene-to-Function Analysis of IL-23R Arg381Gln Polymorphism Reveals Impaired IL-17A Production in Th17 Cells

  Di Meglio, P., Di Cesare, A., Laggner, U., Chu, C.-C., Peris, K. & Nestle, F., 2009, In: CLINICAL IMMUNOLOGY. 131, p. S97 - S97

  Research output: Contribution to journal › Meeting abstract

• Identification of a novel skin homing V gamma 9V delta 2 T cell subset and its potential implication in the immunopathogenesis of psoriasis

  Laggner, U., Di Meglio, P., Hundhausen, C., Perera, G., Smith, C. H., Barker, J., Hayday, A. & Nestle, F., 2009, In: Journal of Investigative Dermatology. 129, p. S88 - S88

  Research output: Contribution to journal › Meeting abstract

• Innate immune function for HLA-Cw6 in psoriasis: reduced expression of HLA-Cw6 facilitates tumour necrosis factor-alpha release due to impaired interaction with inhibitory receptor KIR2DL1

  Hundhausen, C., Mak, R., Botti, E., Laggner, U., Marget, M. & Nestle, F. O., 2009, In: British Journal of Dermatology. 160, 4, p. 909 - 909 1 p.

  Research output: Contribution to journal › Meeting abstract

• Investigating the Role of Skin Homing V gamma 9V delta 2 T Cells as Novel Pathogenic Cells in Psoriasis

  Laggner, U., Di Meglio, P., Hundhausen, C., Perera, G., Botti, E., Hayday, A. & Nestle, F., 2009, In: CLINICAL IMMUNOLOGY. 131, p. S25 - S26

  Research output: Contribution to journal › Meeting abstract

• Regression of melanoma metastases following treatment with the n-bisphosphonate zoledronate and localised radiotherapy

  Laggner, U., Lopez, J. S., Perera, G., Warbey, V., Sita-Lumsden, A., O'Doherty, M. J., Hayday, A., Harries, M. & Nestle, F. O., Jun 2009, In: CLINICAL IMMUNOLOGY. 131, 3, p. 367 - 373 7 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Bone Pain 100%
  25 Citations (Scopus)

• The skin-homing V gamma 9V delta 2 T cell - a potential role in psoriasis?

  Laggner, U., Di Meglio, P., Hundhausen, C., Perera, G., Botti, E., Mak, R., Hayday, A. & Nestle, F. O., 2009, In: British Journal of Dermatology. 160, 4, p. 910 - 910 1 p.

  Research output: Contribution to journal › Meeting abstract
• 2008

  The role of gamma delta T cells in psoriasis

  Laggner, U., Hundhausen, C., Perera, G., Botti, E., Mak, R., Hayday, A. & Nestle, F. O., 2008, In: British Journal of Dermatology. 159, 6, p. 1395 - 1396 2 p.

  Research output: Contribution to journal › Meeting abstract
• 2007

  alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

  Conrad, C., Boyman, O., Tonel, G., Tun-Kyi, A., Laggner, U., de Fougerolles, A., Kotelianski, V., Gardner, H. & Nestle, F., Jul 2007, In: Nature Medicine. 13, 7, p. 836 - 842 7 p.

  Research output: Contribution to journal › Article › peer-review
  235 Citations (Scopus)

• Characterisation of a novel alpha1 integrin positive epithelial-homing effector T cell population in a humanised model of skin inflammation

  Conrad, C., Tonel, G., Di Meglio, P., Laggner, U., Hundhausen, C., de Fougerolles, A., Gardner, H. & Nestle, F. O., 2007, In: Immunology. 120, p. 73 - 73 1 p.

  Research output: Contribution to journal › Meeting abstract