Research output per year
Research output per year
Personal profile
Research interests
<p>We are interested in the function of a group of evolutionarily conserved proteins called Cks proteins. Cks proteins are present in all eukaryotic cells and are expressed in all cell types in the body. Interestingly, they are frequently over-expressed in cancers. Cks1 proteins physically interact with the key regulators of the cell cycle but their precise function has remained elusive for many years. We recently showed a novel function of Cks proteins in regulating transcription, a fundamental cellular process that is key to life. We also found that this regulation involved an interaction with the cell's protein degradation machinery. In this program we are interested in studying the function of Cks proteins using cellular systems and model organisms. Ultimately we wish to relate this information to cancer biology and therapy. By understanding the basic biology, we will address why these proteins are over-expressed in cancers and whether interfering with the function of these proteins would affect cancer progression and/or response to cancer therapy.</p>
<p>More information can be found at http://ecd.csc.mrc.ac.uk/</p>
Research interests (short)
Cyclin-dependent kinase interacting proteins in cancer and neurogenesis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 1 Similar Profiles
Research output
- 7 Article
-
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability
Grey, W., Ivey, A., Milne, T. A., Haferlach, T., Grimwade, D., Uhlmann, F., Voisset, E. & Yu, V., Jan 2018, In: Biochimica et Biophysica Acta. 1865, 1, p. 105-116 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)308 Downloads (Pure) -
Deficiency of the cyclin-dependent kinase inhibitor, CDKN1B, results in overgrowth and neurodevelopmental delay
Grey, W., Izatt, L., Sahraoui, W., Ng, Y.-M., Ogilvie, C., Hulse, A., Tse, E., Holic, R. & Yu, V., Jun 2013, In: Human Mutation. 34, 6, p. 864-8 5 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment
Frontini, M., Kukalev, A., Leo, E., Yiu-Ming Ng, [. V., Cervantes, M., Cheng, C.-W., Holic, R., Dormann, D., Tse, E., Pommier, Y. & Yu, V., 14 Aug 2012, In: Developmental Cell. 23, 2, p. 356-370 15 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Dia2 Controls Transcription by Mediating Assembly of the RSC Complex
Andress, E. J., Holic, R., Edelmann, M. J., Kessler, B. M. & Yu, V. P. C. C., 2011, In: PL o S One . 6, 6, e21172.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Cks1, Cdk1, and the 19S Proteasome Collaborate To Regulate Gene Induction-Dependent Nucleosome Eviction in Yeast
Chaves, S., Baskerville, C., Yu, V. & Reed, S. I., Nov 2010, In: Molecular and Cellular Biology. 30, 22, p. 5284-5294 11 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus)
Projects
- 3 Finished
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Cyclin dependent kinase interacting protein in controlling neuronal plasticity
Yu, V. (Primary Investigator)
21/03/2013 → 20/03/2017
Project: Research
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Cyclin-dependent kinase interacting proteins (CKS) in neurpgenesis
Yu, V. (Primary Investigator)
1/08/2011 → 1/08/2013
Project: Research
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NIHR Biomedical Research Centre
Afzali, B. (Primary Investigator), Antoniou, M. (Primary Investigator), Barker, J. (Primary Investigator), Barratt, B. (Primary Investigator), Beighton, D. (Primary Investigator), Bevan, S. (Primary Investigator), Blower, P. (Primary Investigator), Burchell, J. (Primary Investigator), Cason, J. (Primary Investigator), Chappell, L. (Primary Investigator), Cope, A. (Primary Investigator), Corrigan, C. (Primary Investigator), Cunninghame Graham, D. (Primary Investigator), Dontu, G. (Primary Investigator), Edgeworth, J. (Primary Investigator), Farzaneh, F. (Primary Investigator), Gee, T. (Primary Investigator), Gould, H. (Primary Investigator), Green, P. (Primary Investigator), Greenough, A. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Hayday, A. (Primary Investigator), Higginson, I. (Primary Investigator), Kalra, L. (Primary Investigator), Karagiannis, S. (Primary Investigator), Kelly, F. (Primary Investigator), Kemper, C. (Primary Investigator), Lau-Walker, M. (Primary Investigator), Lavender, P. (Primary Investigator), Lee, T. (Primary Investigator), Lempp, H. (Primary Investigator), Lewis, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Lord, G. (Primary Investigator), Marber, M. (Primary Investigator), Mason, J. (Primary Investigator), Mathew, C. (Primary Investigator), McGrath, J. (Primary Investigator), Metcalfe, A. (Primary Investigator), Molokhia, M. (Primary Investigator), Mullen, G. (Primary Investigator), Nagel, E. (Primary Investigator), Neil, S. (Primary Investigator), Nestle, F. (Primary Investigator), Oakey, R. (Primary Investigator), Parker, P. (Primary Investigator), Peakman, M. (Primary Investigator), Perera, D. (Primary Investigator), Purushotham, A. (Primary Investigator), Rasekh Ahmadi, K. (Primary Investigator), Rashid, T. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Robson, M. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Santis, G. (Primary Investigator), Sanz Moreno, V. (Primary Investigator), Sawyer, E. (Primary Investigator), Schaeffter, T. (Primary Investigator), Shah, A. (Primary Investigator), Sharpe, P. (Primary Investigator), Simpson, M. (Primary Investigator), Smith, R. (Primary Investigator), Sorinola, I. (Primary Investigator), Spector, T. (Primary Investigator), Spicer, J. (Primary Investigator), Taams, L. (Primary Investigator), Tavassoli, M. (Primary Investigator), Taylor, D. (Primary Investigator), Tree, T. (Primary Investigator), Trembath, R. (Primary Investigator), Tribe, R. (Primary Investigator), Tutt, A. (Primary Investigator), Waltham, M. (Primary Investigator), Watt, F. (Primary Investigator), Webb, A. (Primary Investigator), Wells, C. (Primary Investigator), Whelan, K. (Primary Investigator), Whitaker, J. (Primary Investigator), Whittlesea, C. (Primary Investigator), Williamson, C. (Primary Investigator), Wolfe, C. (Primary Investigator), Yu, V. (Primary Investigator), academic, A. (Primary Investigator), Hughes, S. (Co-Investigator), Montana, G. (Co-Investigator), Rhode, K. (Co-Investigator), Schnabel, J. (Co-Investigator) & Tziotzios, C. (Co-Investigator)
NIHR National Institute For Health & Care Research, DHSC Department of Health and Social Care
1/04/2007 → 31/03/2017
Project: Research