King's College London

Research portal

Dr Xiaoke Yin

  1. Preclinical development of a miR-132 inhibitor for heart failure treatment

    Foinquinos, A., Batkai, S., Genschel, C., Viereck, J., Rump, S., Gyöngyösi, M., Traxler, D., Riesenhuber, M., Spannbauer, A., Lukovic, D., Weber, N., Zlabinger, K., Hašimbegović, E., Winkler, J., Fiedler, J., Dangwal, S., Fischer, M., Roche, J. D. L., Wojciechowski, D., Kraft, T. & 8 others, Garamvölgyi, R., Neitzel, S., Chatterjee, S., Yin, X., Bär, C., Mayr, M., Xiao, K. & Thum, T., 1 Dec 2020, In : Nature Communications. 11, 1, 633.

    Research output: Contribution to journalArticle

  2. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

    Grund, A., Szaroszyk, M., Korf-Klingebiel, M., Malek Mohammadi, M., Trogisch, F. A., Schrameck, U., Gigina, A., Tiedje, C., Gaestel, M., Kraft, T., Hegermann, J., Batkai, S., Thum, T., Perrot, A., Remedios, C. D., Riechert, E., Völkers, M., Doroudgar, S., Jungmann, A., Bauer, R. & 9 others, Yin, X., Mayr, M., Wollert, K. C., Pich, A., Xiao, H., Katus, H. A., Bauersachs, J., Müller, O. J. & Heineke, J., 1 Oct 2019, In : EMBO Molecular Medicine. 11, 10, e10018.

    Research output: Contribution to journalArticle

  3. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.

    Yin, X., Wanga, S., Fellows, A. L., Barallobre-Barreiro, J., Lu, R., Davaapil, H., Franken, R., Fava, M., Baig, F., Skroblin, P., Xing, Q., Koolbergen, D. R., Groenink, M., Zwinderman, A. H., Balm, R., de Vries, C. J. M., Mulder, B. J. M., Viner, R., Jahangiri, M., Reinhardt, D. P. & 3 others, Sinha, S., de Waard, V. & Mayr, M., 1 Sep 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 9, p. 1859–1873 15 p.

    Research output: Contribution to journalArticle

  4. Locally different proteome in aortas from patients with stenotic tricuspid and bicuspid aortic valves†

    Forte, A., Yin, X., Fava, M., Bancone, C., Cipollaro, M., De Feo, M., Mayr, M., Jahangiri, M. & Della Corte, A., 1 Sep 2019, In : European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 56, 3, p. 458-469 12 p.

    Research output: Contribution to journalArticle

  5. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children

    Posod, A., Pechlaner, R., Yin, X., Burnap, S. A., Kiechl, S. J., Willeit, J., Witztum, J. L., Mayr, M., Kiechl, S. & Kiechl-Kohlendorfer, U., 16 Apr 2019, In : Journal of the American Heart Association. 8, 8, p. e011199 e011199.

    Research output: Contribution to journalArticle

  6. Inhibition of Pro-Fibrotic MicroRNA-21 Affects Platelets and their Releasate

    Barwari, T., Eminaga, S., Mayr, U., Lu, R., Armstrong, P. C., Chan, M. V., Sahraei, M., Fernandez-Fuertes, M., Moreau, T., Barallobre-Barreiro, J., Lynch, M., Yin, X., Schulte, C., Baig, F., Pechlaner, R., Langley, S. R., Zampetaki, A., Santer, P., Weger, M., Plasenzotti, R. & 10 others, Schosserer, M., Grillari, J., Kiechl, S., Willeit, J., Shah, A. M., Ghevaert, C., Warner, T. D., Fernández-Hernando, C., Suárez, Y. & Mayr, M., 2 Nov 2018, In : JCI Insight.

    Research output: Contribution to journalArticle

  7. Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling

    Fava, M., Barallobre-Barreiro, J., Mayr, U., Lu, R., Didangelos, A., Baig, F., Lynch, M., Catibog, N. R., Joshi, A., Barwari, T., Yin, X., Jahangiri, M. & Mayr, M., 5 Apr 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 2018, 38, p. 1537-1548 11 p., 10.1161/ATVBAHA.117.310562.

    Research output: Contribution to journalLiterature review

  8. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

    Suna, G., Wojakowski, W., Lynch, M., Barallobre-Barreiro, J., Yin, X., Mayr, U., Baig, F., Lu, R., Fava, M., Hayward, R., Molenaar, C., White, S. J., Roleder, T., Milewski, K., Gasior, P., Buszman, P. P., Buszman, P. E., Jahangiri, M., Shanahan, C., Hill, J. M. & 1 others, Mayr, M., 9 Jan 2018, In : Circulation (Baltimore). 137, 2, p. 166-183

    Research output: Contribution to journalArticle

  9. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

    Nabeebaccus, A. A., Zoccarato, A., Hafstad, A. D., Santos, C. X., Aasum, E., Brewer, A. C., Zhang, M., Beretta, M., Yin, X., West, J. A., Schröder, K., Griffin, J. L., Eykyn, T. R., Abel, E. D., Mayr, M. & Shah, A. M., 21 Dec 2017, In : JCI Insight. 2, 24

    Research output: Contribution to journalArticle

  10. Plasma Proteomics for Epidemiology: Increasing Throughput with Standard-Flow Rates

    Yin, X., Baig, F., Haudebourg, E., Blankley, R. T., Gandhi, T., Müller, S., Reiter, L., Hinterwirth, H., Pechlaner, R., Tsimikas, S., Santer, P., Willeit, J., Kiechl, S., Witztum, J. L., Sullivan, A. & Mayr, M., Dec 2017, In : Circulation-Cardiovascular Genetics. 10, 6

    Research output: Contribution to journalArticle

  11. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

    Sassi, Y., Avramopoulos, P., Ramanujam, D., Grüter, L., Werfel, S., Giosele, S., Brunner, A-D., Esfandyari, D., Papadopoulou, A. S., De Strooper, B., Hübner, N., Kumarswamy, R., Thum, T., Yin, X., Mayr, M., Laggerbauer, B. & Engelhardt, S., 20 Nov 2017, In : Nature Communications. 8, 1, p. 1614 1 p.

    Research output: Contribution to journalArticle

  12. Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation

    Viviano, A., Yin, X., Zampetaki, A., Fava, M., Gallagher, M., Mayr, M. & Jahangiri, M., 5 Jun 2017, In : EUROPACE. eux113.

    Research output: Contribution to journalArticle

  13. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

    Langley, S. R., Willeit, K., Didangelos, A., Matic, L. P., Skroblin, P., Barallobre-barreiro, J., Lengquist, M., Rungger, G., Kapustin, A., Kedenko, L., Molenaar, C., Lu, R., Barwari, T., Suna, G., Yin, X., Iglseder, B., Paulweber, B., Willeit, P., Shalhoub, J., Pasterkamp, G. & 7 others, Davies, A. H., Monaco, C., Hedin, U., Shanahan, C. M., Willeit, J., Kiechl, S. & Mayr, M., 3 Apr 2017, In : Journal of Clinical Investigation. 127, 4, p. 1546-1560

    Research output: Contribution to journalArticle

  14. Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

    Pechlaner, R., Tsimikas, S., Yin, X., Willeit, P., Baig, F., Santer, P., Oberhollenzer, F., Egger, G., Witztum, J. L., Alexander, V. J., Willeit, J., Kiechl, S. & Mayr, M., 21 Feb 2017, In : Journal of the American College of Cardiology. 69, 7, p. 789-800 12 p.

    Research output: Contribution to journalArticle

  15. Circulating MicroRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes

    Willeit, P., Skroblin, P., Moschen, A. R., Yin, X., Kaudewitz, D., Zampetaki, A., Barwari, T., Whitehead, M., Ramírez, C. M., Goedeke, L., Rotllan, N., Bonora, E., Hughes, A. D., Santer, P., Fernández-Hernando, C., Tilg, H., Willeit, J., Kiechl, S. & Mayr, M., 1 Feb 2017, In : Diabetes. 66, 2, p. 347-357 11 p.

    Research output: Contribution to journalArticle

  16. Premature senescence of endothelial cells upon chronic exposure to TNFα can be prevented by N-acetyl cysteine and plumericin

    Khan, S. Y., Awad, E. M., Oszwald, A., Mayr, M., Yin, X., Waltenberger, B., Stuppner, H., Lipovac, M., Uhrin, P. & Breuss, J. M., 3 Jan 2017, In : Scientific Reports. 7, p. 39501 EP -

    Research output: Contribution to journalArticle

  17. Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling

    Hermida, N., Michel, L., Esfahani, H., Dubois-Deruy, E., Hammond, J., Bouzin, C., Markl, A., Colin, H., Steenbergen, A. V., De Meester, C., Beauloye, C., Horman, S., Yin, X., Mayr, M. & Balligand, J-L., 2017, In : European Heart Journal. p. ehx366

    Research output: Contribution to journalArticle

  18. Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation

    Barallobre-Barreiro, J., Gupta, S. K., Zoccarato, A., Kitazume-Taneike, R., Fava, M., Yin, X., Werner, T., Hirt, M. N., Zampetaki, A., Viviano, A., Chong, M., Bern, M., Kourliouros, A., Domenech, N., Willeit, P., Shah, A. M., Jahangiri, M., Schaefer, L., Fischer, J. W., Iozzo, R. V. & 6 others, Viner, R., Thum, T., Heineke, J., Kichler, A., Otsu, K. & Mayr, M., 13 Sep 2016, In : Circulation (Baltimore). 134, 11, p. 817-832 16 p.

    Research output: Contribution to journalArticle

  19. Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis

    Bauer, A., Mylroie, H., Thornton, C. C., Calay, D., Birdsey, G. M., Kiprianos, A. P., Wilson, G. K., Soares, M. P., Yin, X., Mayr, M., Randi, A. M. & Mason, J. C., 8 Jul 2016, In : Scientific Reports. 6, p. 29417

    Research output: Contribution to journalArticle

  20. Extracellular matrix remodelling in response to venous hypertension: Proteomics of human varicose veins

    Barallobre-Barreiro, J., Oklu, R., Lynch, M., Fava, M., Baig, F., Yin, X., Barwari, T., Potier, D. N., Albadawi, H., Jahangiri, M., Porter, K. E., Watkins, M. T., Misra, S., Stoughton, J. & Mayr, M., 1 Jun 2016, In : Cardiovascular Research. 110, 3, p. 419-430 12 p.

    Research output: Contribution to journalArticle

  21. "Young at heart": Regenerative potential linked to immature cardiac phenotypes

    Gomes, R. S. M., Skroblin, P., Munster, A. B., Tomlins, H., Langley, S. R., Zampetaki, A., Yin, X., Wardle, F. C. & Mayr, M., 1 Mar 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 105-108 4 p.

    Research output: Contribution to journalArticle

  22. Angiogenic MicroRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes

    Zampetaki, A., Willeit, P., Burr, S. J., Yin, X., Langley, S. R., Kiechl, S., Klein, R., Rossing, P., Chaturvedi, N. & Mayr, M., Jan 2016, In : Diabetes. 65, 1, p. 216-27 11 p.

    Research output: Contribution to journalArticle

  23. XBP 1-deficiency abrogates neointimal lesion of injured vessels via cross talk with the PDGF signaling

    Zeng, L., Li, Y., Yang, J., Wang, G., Margariti, A., Xiao, Q., Zampetaki, A., Yin, X., Mayr, M., Mori, K., Wang, W., Hu, Y. & Xu, Q., 25 Oct 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 10, p. 2134-2144 11 p.

    Research output: Contribution to journalArticle

  24. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport

    Štalekar, M., Yin, X., Rebolj, K., Darovic, S., Troakes, C., Mayr, M., Shaw, C. E. & Rogelj, B., 7 May 2015, In : Neuroscience. 293, p. 157-170 14 p.

    Research output: Contribution to journalArticle

  25. Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

    Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., Shroff, R., Yin, X., Muller, K., Skepper, J. N., Mayr, M., Reutelingsperger, C. P., Chester, A., Bertazzo, S., Schurgers, L. J. & Shanahan, C. M., 10 Apr 2015, In : Circulation Research. 116, 8, p. 1312-1323 12 p.

    Research output: Contribution to journalArticle

  26. ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1

    Kessler, T., Zhang, L., Liu, Z., Yin, X., Huang, Y., Wang, Y., Mayr, M., Ge, Q., Xu, Q., Zhu, Y., Wang, X., Schmidt, K., de Wit, C., Erdmann, J., Schunkert, H., Aherrahrou, Z., Kong, W. & German Mouse Clinic Consortium, 31 Mar 2015, In : Circulation (Baltimore). 131, 13, p. 1191-+ 52 p.

    Research output: Contribution to journalArticle

  27. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart

    Nabeebaccus, A., Hafstad, A., Eykyn, T., Yin, X., Brewer, A., Zhang, M., Mayr, M. & Shah, A., 26 Feb 2015, In : Lancet. 385 Suppl 1, p. S73

    Research output: Contribution to journalArticle

  28. Over-Expression of HSP47 Augments Mouse Embryonic Stem Cell Smooth Muscle Differentiation and Chemotaxis

    Wong, M. M., Yin, X., Potter, C., Yu, B., Cai, H., Di Bernardini, E. & Xu, Q., 16 Jan 2014, In : PL o S One . 9, 1, p. N/A 8 p., e86118.

    Research output: Contribution to journalArticle

  29. Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation

    Xiao, Q., Zhang, F., Grassia, G., Hu, Y., Zhang, Z., Xing, Q., Yin, X., Maddaluno, M., Drung, B., Schmidt, B., Maffia, P., Ialenti, A., Mayr, M., Xu, Q. & Ye, S., Jan 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 1, p. 90-98 9 p.

    Research output: Contribution to journalArticle

  30. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

    Bang, C., Batkai, S., Dangwal, S., Gupta, S. K., Foinquinos, A., Holzmann, A., Just, A., Remke, J., Zimmer, K., Zeug, A., Ponimaskin, E., Schmiedl, A., Yin, X., Mayr, M., Halder, R., Fischer, A., Engelhardt, S., Wei, Y., Schober, A., Fiedler, J. & 1 others, Thum, T., 2014, In : The Journal of clinical investigation. 124, 5, p. 2136-2146 11 p.

    Research output: Contribution to journalArticle

  31. Accepted/In press

    Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

    Goedeke, L., Salerno, A., Ramírez, C. M., Guo, L., Allen, R. M., Yin, X., Langley, S. R., Esau, C., Wanschel, A., Fisher, E. A., Suárez, Y., Baldán, A., Mayr, M. & Fernández-Hernando, C., 2014, (Accepted/In press) In : EMBO Molecular Medicine.

    Research output: Contribution to journalArticle

  32. Role of miR-195 in aortic aneurysmal disease

    Zampetaki, A., Attia, R. Q., Mayr, U., Gomes, R. S., Phinikaridou, A., Yin, X., Langley, S., Willeit, P., Lu, R., Fanshawe, B., Fava, M., Barallobre-Barreiro, J., Molenaar, C., So, P-W., Abbas, A., Jahangiri, M., Waltham, M., Botnar, R., Smith, A. & Mayr, M., 2014, In : Circulation Research. 115, 10, p. 857-866 10 p.

    Research output: Contribution to journalArticle

  33. Histone Deacetylase 3 Unconventional Splicing Mediates Endothelial-to-mesenchymal Transition through Transforming Growth Factor β2

    Zeng, L., Wang, G., Ummarino, D., Margariti, A., Xu, Q., Xiao, Q., Wang, W., Zhang, Z., Yin, X., Mayr, M., Cockerill, G., Li, J. Y., Chien, S., Hu, Y. & Xu, Q., 1 Nov 2013, In : Journal of Neuroscience, Journal of Biological Chemistry. 288, 44, p. 31853-31866 14 p., N/A.

    Research output: Contribution to journalArticle

  34. Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure

    Heymans, S., Corsten, M. F., Verhesen, W., Carai, P., van Leeuwen, R. E. W., Custers, K., Peters, T., Hazebroek, M., Stoeger, L., Wijnands, E., Janssen, B. J., Creemers, E. E., Pinto, Y. M., Grimm, D., Schuermann, N., Vigorito, E., Thum, T., Stassen, F., Yin, X., Mayr, M. & 9 others, de Windt, L. J., Lutgens, E., Wouters, K., de Winther, M. P. J., Zacchigna, S., Giacca, M., van Bilsen, M., Papageorgiou, A-P. & Schroen, B., 24 Sep 2013, In : Circulation (Baltimore). 128, 13, p. 1420-1432 13 p., N/A.

    Research output: Contribution to journalArticle

  35. The Hypoxia-Inducible MicroRNA Cluster miR-199a similar to 214 Targets Myocardial PPAR delta and Impairs Mitochondrial Fatty Acid Oxidation

    el Azzouzi, H., Leptidis, S., Dirkx, E., Hoeks, J., van Bree, B., Brand, K., McClellan, E. A., Poels, E., Sluimer, J. C., van den Hoogenhof, M. M. G., Armand, A-S., Yin, X., Langley, S., Bourajjaj, M., Olieslagers, S., Krishnan, J., Vooijs, M., Kurihara, H., Stubbs, A., Pinto, Y. M. & 5 others, Krek, W., Mayr, M., Martins, P. A. D. C., Schrauwen, P. & De Windt, L. J., 3 Sep 2013, In : CELL METABOLISM. 18, 3, p. 341-354 14 p., N/A.

    Research output: Contribution to journalArticle

  36. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties

    Dalli, J., Montero-Melendez, T., Norling, L. V., Yin, X., Hinds, C., Haskard, D., Mayr, M. & Perretti, M., Aug 2013, In : Molecular & cellular proteomics : MCP. 12, 8, p. 2205-2219 15 p.

    Research output: Contribution to journalArticle

  37. Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions

    Xiao, Q., Zhang, F., Lin, L., Fang, C., Wen, G., Tsai, T-N., Pu, X., Sims, D., Zhang, Z., Yin, X., Thomaszewski, B., Schmidt, B., Mayr, M., Suzuki, K., Xu, Q. & Ye, S., 4 Jan 2013, In : Circulation Research. 112, 1, p. 35-47 13 p., N/A.

    Research output: Contribution to journalArticle

  38. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques

    Frömel, T., Kohlstedt, K., Popp, R., Yin, X., Awwad, K., Barbosa-Sicard, E., Thomas, A. C., Lieberz, R., Mayr, M. & Fleming, I., Jan 2013, In : Basic Research in Cardiology. 108, 1, 319.

    Research output: Contribution to journalArticle

  39. Glycoproteomic analysis of the secretome of human endothelial cells

    Yin, X., Bern, M., Xing, Q., Ho, J., Viner, R. & Mayr, M., 2013, In : Molecular & cellular proteomics : MCP.

    Research output: Contribution to journalArticle

  40. Proteomics: from single molecules to biological pathways

    Langley, S. R., Dwyer, J., Drozdov, I., Yin, X. & Mayr, M., 2013, In : Cardiovascular Research. 97, 4, p. 612-622 11 p.

    Research output: Contribution to journalArticle

  41. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes

    Randriamboavonjy, V., Isaak, J., Elgheznawy, A., Pistrosch, F., Froemel, T., Yin, X., Badenhoop, K., Heide, H., Mayr, M. & Fleming, I., 12 Jul 2012, In : Blood. 120, 2, p. 415-423 9 p.

    Research output: Contribution to journalArticle

  42. Proteomics Analysis of Cardiac Extracellular Matrix Remodeling in a Porcine Model of Ischemia/Reperfusion Injury

    Barallobre-Barreiro, J., Didangelos, A., Schoendube, F. A., Drozdov, I., Yin, X., Fernandez-Caggiano, M., Willeit, P., Puntmann, V. O., Aldama-Lopez, G., Shah, A. M., Domenech, N. & Mayr, M., 14 Feb 2012, In : Circulation (Baltimore). 125, 6, p. 789 - 802 14 p.

    Research output: Contribution to journalArticle

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