King's College London

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Dr Yoshitsugu Adachi

  1. A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

    Solomon, D. A., Stepto, A., Au, W. H., Adachi, Y., Diaper, D. C., Hall, R., Rekhi, A., Boudi, A., Tziortzouda, P., Lee, Y. B., Smith, B., Bridi, J. C., Spinelli, G., Dearlove, J., Humphrey, D. M., Gallo, J. M., Troakes, C., Fanto, M., Soller, M., Rogelj, B. & 4 others, Parsons, R. B., Shaw, C. E., Hortobágyi, T. & Hirth, F., 1 Oct 2018, In : Brain. 141, 10, p. 2908-2924 17 p.

    Research output: Contribution to journalArticle

  2. Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioral phenotypes that characterize ALS and FTLD

    Diaper, D. C., Adachi, Y., Lazarou, L., Greenstein, M., Simoes, F. A., Di Domenico, A., Solomon, D. A., Lowe, S., Alsubaie, R., Cheng, D., Buckley, S., Humphrey, D. M., Shaw, C. E. & Hirth, F., 1 Oct 2013, In : Human Molecular Genetics. 22, 19, p. 3883-3893 11 p.

    Research output: Contribution to journalArticle

  3. Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

    Diaper, D., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C. J. H., Stepto, A., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E., Robinson, I. M. & Hirth, F., 15 Apr 2013, In : Human Molecular Genetics. 22, 8, p. 1539-1557 19 p.

    Research output: Contribution to journalArticle

  4. TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophilia

    Vanden Broeck, L., Naval-Sánchez, M., Adachi, Y., Diaper, D., Dourlen, P., Chapuis, J., Kleinberger, G., Gistelinck, M., Van Broeckhoven, C., Lambert, J-C., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., 31 Jan 2013, In : Cell Reports. 3, 1, p. 160-172 13 p.

    Research output: Contribution to journalArticle

  5. TDP-43 neurotoxicity by failed steroid receptor-dependent transcriptional program switching

    Vanden Broeck, L., Sanchez, N. M., Adachi, Y., Diaper, D., Dourlen, P., Gistelinck, M., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., Dec 2012, In : Journal of Neurogenetics. 26, S1, p. 80-81 2 p., P281.

    Research output: Contribution to journalMeeting abstract

  6. Both loss and gain of TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration in Drosophilia

    Diaper, D. C., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C., Fielding, T., Burki, M., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E. & Hirth, F., Sep 2012, In : Dementia and Geriatric Cognitive Disorders. 34, S1, p. 51-51 1 p., P10.

    Research output: Contribution to journalMeeting abstract

  7. Function and specificity of synthetic Hox transcription factors in vivo

    Papadopoulos, D. K., Vukojevic, V., Adachi, Y., Terenius, L., Rigler, R. & Gehring, W. J., 2 Mar 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4087 - 4092 6 p.

    Research output: Contribution to journalArticle

  8. Drosophila models of TDP-43 proteinopathy

    Adachi, Y., Diaper, D., Burki, M. & Hirth, F., 16 Feb 2010, In : Journal of Neurogenetics. 24, 7, p. 60 - 60 1 p.

    Research output: Contribution to journalMeeting abstract

  9. TDP-43 in motor neuron disease formation in Drosophila

    Diaper, D., Adachi, Y. & Hirth, F., 2010, In : Journal of Neurogenetics. 24, p. 66 - 67 2 p.

    Research output: Contribution to journalMeeting abstract

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