Research output per year
Research output per year
- 11 results
Search results
-
2018
A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration
Solomon, D. A., Stepto, A., Au, W. H., Adachi, Y., Diaper, D. C., Hall, R., Rekhi, A., Boudi, A., Tziortzouda, P., Lee, Y. B., Smith, B., Bridi, J. C., Spinelli, G., Dearlove, J., Humphrey, D. M., Gallo, J. M., Troakes, C., Fanto, M., Soller, M. & Rogelj, B. & 4 others, , 1 Oct 2018, In: Brain. 141, 10, p. 2908-2924 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Citations (Scopus)296 Downloads (Pure) -
2017
C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity
Lee, Y.-B., Baskaran, P., Gomez-Deza, J., Chen, H.-J., Nishimura, A. L., Smith, B. N., Troakes, C., Adachi, Y., Stepto, A., Petrucelli, L., Gallo, J.-M., Hirth, F., Rogelj, B., Guthrie, S. & Shaw, C. E., 15 Dec 2017, In: Human Molecular Genetics. 26, 24, p. 4765-4777 13 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Citations (Scopus) -
2013
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioral phenotypes that characterize ALS and FTLD
Diaper, D. C., Adachi, Y., Lazarou, L., Greenstein, M., Simoes, F. A., Di Domenico, A., Solomon, D. A., Lowe, S., Alsubaie, R., Cheng, D., Buckley, S., Humphrey, D. M., Shaw, C. E. & Hirth, F., 1 Oct 2013, In: Human Molecular Genetics. 22, 19, p. 3883-3893 11 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Citations (Scopus) -
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Lee, Y., Chen, H.-J., Peres, J. N., Gomez Deza, J., Attig, J., Stalekar, M., Troakes, C., Nishimura, A. L., Scotter, E. L., Vance, C., Adachi, Y., Sardone, V., Miller, J. W., Smith, B. N., Gallo, J.-M., Ule, J., Hirth, F., Rogelj, B., Houart, C. & Shaw, C. E., 12 Dec 2013, In: Cell Reports. 5, 5, p. 1178-1186 9 p.Research output: Contribution to journal › Article › peer-review
Open Access379 Citations (Scopus) -
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
Diaper, D., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C. J. H., Stepto, A., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E., Robinson, I. M. & Hirth, F., 15 Apr 2013, In: Human Molecular Genetics. 22, 8, p. 1539-1557 19 p.Research output: Contribution to journal › Article › peer-review
Open Access104 Citations (Scopus) -
TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophilia
Vanden Broeck, L., Naval-Sánchez, M., Adachi, Y., Diaper, D., Dourlen, P., Chapuis, J., Kleinberger, G., Gistelinck, M., Van Broeckhoven, C., Lambert, J.-C., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., 31 Jan 2013, In: Cell Reports. 3, 1, p. 160-172 13 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Citations (Scopus) -
2012
Both loss and gain of TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration in Drosophilia
Diaper, D. C., Adachi, Y., Sutcliffe, B., Humphrey, D. M., Elliott, C., Fielding, T., Burki, M., Ludlow, Z. N., Vanden Broeck, L., Callaerts, P., Dermaut, B., Al-Chalabi, A., Shaw, C. E. & Hirth, F., Sept 2012, In: Dementia and Geriatric Cognitive Disorders. 34, S1, p. 51-51 1 p., P10.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access47 Citations (Scopus) -
TDP-43 neurotoxicity by failed steroid receptor-dependent transcriptional program switching
Vanden Broeck, L., Sanchez, N. M., Adachi, Y., Diaper, D., Dourlen, P., Gistelinck, M., Hirth, F., Aerts, S., Callaerts, P. & Dermaut, B., Dec 2012, In: Journal of Neurogenetics. 26, S1, p. 80-81 2 p., P281.Research output: Contribution to journal › Meeting abstract › peer-review
-
2010
Drosophila models of TDP-43 proteinopathy
Adachi, Y., Diaper, D., Burki, M. & Hirth, F., 16 Feb 2010, In: Journal of Neurogenetics. 24, 7, p. 60 - 60 1 p.Research output: Contribution to journal › Meeting abstract
233 Citations (Scopus) -
Function and specificity of synthetic Hox transcription factors in vivo
Papadopoulos, D. K., Vukojevic, V., Adachi, Y., Terenius, L., Rigler, R. & Gehring, W. J., 2 Mar 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 4087 - 4092 6 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
TDP-43 in motor neuron disease formation in Drosophila
Diaper, D., Adachi, Y. & Hirth, F., 2010, In: Journal of Neurogenetics. 24, p. 66 - 67 2 p.Research output: Contribution to journal › Meeting abstract