Research output per year
Research output per year
Personal profile
Research interests
Gene expression is precisely regulated at the post-transcriptional level, which controlled by small RNAs and it’s binding proteins. The fundamental steps of mRNA processing or silencing have been characterized in great detail, but knowledge of how the disruption of these processes contributes to human disease has only recently begun to emerge.
I am investigating noncoding RNAs and RNA binding proteins, such as heterogeneous RNA ribonucleoproteins (hnRNPs) and its role in neurodegenerative disease progress.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia
Gomez Suaga, P., Morotz, G., Markovinovic, A., Martin Guerrero, S., Preza, E., Arias Del Castillo, N., Mayl, K., Aabdien, A., Gesheva, V., Nishimura, A., Annibali, A., Lee, Y., Mitchell, J., Wray, S., Shaw, C., Noble, W. & Miller, C., Feb 2022, In: AGING CELL. 21, 2, 15 p., e13549.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)290 Downloads (Pure) -
Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA
Bozič, J., Motaln, H., Janez, A. P., Markič, L., Tripathi, P., Yamoah, A., Aronica, E., Lee, Y. B., Heilig, R., Fischer, R., Thompson, A. J., Goswami, A. & Rogelj, B., 1 Feb 2022, In: Brain. 145, 2, p. 684-699 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Cytoplasmic TDP-43 is involved in cell fate during stress recovery
Lee, Y-B., Scotter, E. L., Lee, D-Y., Troakes, C., Mitchell, J., Rogelj, B., Gallo, J-M. & Shaw, C. E., 27 Dec 2021, In: Human Molecular Genetics. 31, 2, 10 p., ddab227.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Disease mechanisms and therapeutic approaches in c9orf72 als-ftd
Mayl, K., Shaw, C. E. & Lee, Y. B., Jun 2021, In: Biomedicines. 9, 6, 601.Research output: Contribution to journal › Review article › peer-review
Open Access7 Citations (Scopus) -
Regulation of synapse weakening through interactions of the microtubule associated protein tau with pacsin1
Regan, P., Mitchell, S. J., Kim, S. C., Lee, Y., Yi, J. H., Barbati, S. A., Shaw, C. & Cho, K., 25 Aug 2021, In: Journal of Neuroscience. 41, 34, p. 7162-7170 9 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
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Developing AAV gene therapy for Motor Neuron Disease
Motor Neurone Disease Association
1/02/2023 → 31/01/2026
Project: Research
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Arresting corona virus replication using microRNA to knock down the essential RDRP protein
UK Dementia Research Institute
1/04/2020 → 31/03/2021
Project: Research
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Viral vector gene therapy for FTD and ALS: from constructs to clinical trials
Shaw, C., Lee, Y. & Farzaneh, F.
UK Dementia Research Institute
1/01/2019 → 31/12/2022
Project: Research
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