Research output per year
Research output per year
Personal profile
Research interests
Gene expression is precisely regulated at the post-transcriptional level, which controlled by small RNAs and it’s binding proteins. The fundamental steps of mRNA processing or silencing have been characterized in great detail, but knowledge of how the disruption of these processes contributes to human disease has only recently begun to emerge.
I am investigating noncoding RNAs and RNA binding proteins, such as heterogeneous RNA ribonucleoproteins (hnRNPs) and its role in neurodegenerative disease progress.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mutations in FUS lead to synaptic dysregulation in ALS-iPSC derived neurons
Shum, C., Hedges, E. C., Allison, J., Lee, Y. B., Arias, N., Cocks, G., Chandran, S., Ruepp, M. D., Shaw, C. E. & Nishimura, A. L., 18 Jan 2024, In: Stem cell reports. 19, 2, p. 187-195 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
Markovinovic, A., Martin Guerrero, S., Morotz, G., Salam, S., Gomez Suaga, P., Paillusson, S., Greig, J., Lee, Y., Mitchell, J., Noble, W. & Miller, C., 23 Feb 2024, In: Acta Neuropathologica Communications.Research output: Contribution to journal › Article › peer-review
File193 Downloads (Pure) -
Updated T2K measurements of muon neutrino and antineutrino disappearance using 3.6 $\times$ 10$^{21}$ protons on target
The T2K Collaboration, Ali, A., Barker, G. J., Blondel, A., Carter, A. J., Cartwright, S. L., Coleman, J., Cook, L., Dasgupta, P., Lodovico, F. D., Doyle, T. A., Finch, A. J., Harris, D. A., Jenkins, S. J., Jiang, J. J., Joshi, S., Katori, T., King, S., Kodama, S. & Latham, N. & 34 others, , 17 May 2023, 7 ed., Physical Review D.Research output: Working paper/Preprint › Preprint
Open AccessFile50 Downloads (Pure) -
Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia
Gomez Suaga, P., Morotz, G., Markovinovic, A., Martin Guerrero, S., Preza, E., Arias Del Castillo, N., Mayl, K., Aabdien, A., Gesheva, V., Nishimura, A., Annibali, A., Lee, Y., Mitchell, J., Wray, S., Shaw, C., Noble, W. & Miller, C., Feb 2022, In: AGING CELL. 21, 2, 15 p., e13549.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)452 Downloads (Pure) -
Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA
Bozič, J., Motaln, H., Janez, A. P., Markič, L., Tripathi, P., Yamoah, A., Aronica, E., Lee, Y. B., Heilig, R., Fischer, R., Thompson, A. J., Goswami, A. & Rogelj, B., 1 Feb 2022, In: Brain. 145, 2, p. 684-699 16 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus)
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Accelerating the proof-of-concept study for FUS AAV gene therapy
Lee, Y. (Primary Investigator), Lee, D. Y. (Co-Investigator) & lee, D. (Co-Investigator)
3/02/2025 → 2/10/2025
Project: Research
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Developing AAV Gene therapy for C9orf72 ALS/FTD
Lee, Y. (Primary Investigator)
1/05/2024 → 30/04/2027
Project: Research
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Developing AAV gene therapy for Motor Neuron Disease
Lee, Y. (Primary Investigator) & Shaw, C. (Co-Investigator)
Motor Neurone Disease Association
1/02/2023 → 31/01/2026
Project: Research
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AAV gene therapy for mutant FUS Amyotrophic Lateral Sclerosis
Lee, Y. (Primary Investigator), Ruepp, M.-D. (Co-Investigator), Shaw, C. (Co-Investigator) & Vance, C. (Co-Investigator)
1/10/2022 → 30/09/2024
Project: Research
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Arresting corona virus replication using microRNA to knock down the essential RDRP protein
Shaw, C. (Primary Investigator) & Lee, Y. (Co-Investigator)
UK Dementia Research Institute
1/04/2020 → 31/03/2021
Project: Research