Research output per year
Research output per year
Personal profile
Research interests
My interest is in a family of inherited neurodegenerative diseases relating to polyglutamine (polyQ) expansion. The main objectives of my research programme are to obtain structural knowledge of these disease proteins, as well as understanding the cytotoxicity of polyQ expansion and how it can be counteracted. The study of inhibition of aggregation holds big promises in discovering treatments for this disease family as well as for other neurodegenerative disorders involving protein misfolding. A diverse range of complementary structural techniques are used to tackle this problem: e.g. X-ray crystallography, biophysical methods and computational molecular modeling and simulation.
Research interests (short)
Interdisciplinary approach to study the structure, function and interactions of proteins implicated in misfolding neurodegenerative diseases.
Click here Chen group webpage.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Structural Studies of Barnase Mutants, University of Cambridge
Award Date: 1 Jan 1995
Bachelor of Science, Imperial College London
Award Date: 1 Jan 1990
Bachelor of Architecture, University of Hong Kong
Award Date: 1 Jan 1985
Bachelor of Arts, University of Hong Kong
Award Date: 1 Jan 1983
Keywords
- QD Chemistry
- Biochemistry
- X-ray Crystallography
- Structural Biology
- Biophysics
- Neurodegeneration
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- 1 Similar Profiles
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Structure of UreG/UreF/UreH Complex Reveals How Urease Accessory Proteins Facilitate Maturation of Helicobacter pylori Urease
Fong, Y. H., Wong, H. C., Yuen, M. H., Lau, P. H., Chen, Y. W. & Wong, K-B., 8 Oct 2013, In: PL o S Biology. 11, 10, p. N/A 16 p., e1001678.Research output: Contribution to journal › Article › peer-review
Open Access95 Citations (Scopus) -
Self-Assembly and Conformational Heterogeneity of the AXH Domain of Ataxin-1: An Unusual Example of a Chameleon Fold
de Chiara, C., Rees, M., Menon, R. P., Pauwels, K., Lawrence, C., Konarev, P. V., Svergun, D. I., Martin, S. R., Chen, Y. W. & Pastore, A., 19 Mar 2013, In: Biophysical Journal. 104, 6, p. 1304-13 10 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Solution model of the intrinsically disordered polyglutamine tract-binding protein-1
Rees, M., Gorba, C., de Chiara, C., Bui, T. T. T., Garcia-Maya, M., Drake, A. F., Okazawa, H., Pastore, A., Svergun, D. & Chen, Y. W., 4 Apr 2012, In: Biophysical Journal. 102, 7, p. 1608 - 1616 9 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
Assembly of preactivation complex for urease maturation in Helicobacter pylori: crystal structure of UreF-UreH protein complex
Fong, Y. H., Wong, H. C., Chuck, C. P., Chen, Y. W., Sun, H. & Wong, K-B., 16 Dec 2011, In: Journal of Biological Chemistry. 286, 50, p. 43241 - 43249 9 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
The structure of the AXH domain of spinocerebellar ataxin-1.
Chen, Y. W., Allen, M., Veprintsev, D. B., Löwe, J. & Bycroft, M., 30 Jan 2004, In: Journal of Biological Chemistry. 279, 5, p. 3758 - 3765 8 p.Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus)
Projects
- 8 Finished
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The structure and interactions of Ataxin-1 (30Q), a polyglutamine expansion disease protein
1/06/2014 → 31/05/2017
Project: Research
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A small-angle X-ray scattering (SAXS) station for in-house data collection on macromolecular complexes
Sanderson, M., Beavil, A., Chen, Y., Steiner, R. & Sutton, B.
1/10/2013 → 30/09/2016
Project: Research
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X-ray crystallographic studies of the inhibition of Pak1 by IPA-3
1/04/2011 → 31/03/2012
Project: Research
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Structure and interactions of dribble and its RNA targets
University of London Central Research Fund
1/05/2009 → 30/04/2010
Project: Research
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Molecular Neurobiology (Journal)
Yu Chen (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Journal of Biological Chemistry (Journal)
Yu Chen (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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ACTA CRYSTALLOGRAPHICA SECTION D BIOLOGICAL CRYSTALLOGRAPHY (Journal)
Yu Chen (Peer reviewer)
2012 → …Activity: Publication peer-review and editorial work › Publication peer-review
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Future Medicinal Chemistry (Journal)
Yu Chen (Peer reviewer)
2011 → …Activity: Publication peer-review and editorial work › Publication peer-review
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PL o S One (Journal)
Yu Chen (Peer reviewer)
2010 → …Activity: Publication peer-review and editorial work › Publication peer-review
Prizes
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Fellow of the Higher Education Academy, UK
Chen, Yu (Recipient), 2007
Prize: Fellowship awarded competitively