Yu Chen

Yu Chen


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Personal profile

Research interests

My interest is in a family of inherited neurodegenerative diseases relating to polyglutamine (polyQ) expansion. The main objectives of my research programme are to obtain structural knowledge of these disease proteins, as well as understanding the cytotoxicity of polyQ expansion and how it can be counteracted. The study of inhibition of aggregation holds big promises in discovering treatments for this disease family as well as for other neurodegenerative disorders involving protein misfolding. A diverse range of complementary structural techniques are used to tackle this problem: e.g. X-ray crystallography, biophysical methods and computational molecular modeling and simulation.

Research interests (short)

Interdisciplinary approach to study the structure, function and interactions of proteins implicated in misfolding neurodegenerative diseases.

Click here Chen group webpage.


Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Structural Studies of Barnase Mutants, University of Cambridge

Award Date: 1 Jan 1995

Bachelor of Science, Imperial College London

Award Date: 1 Jan 1990

Bachelor of Architecture, University of Hong Kong

Award Date: 1 Jan 1985

Bachelor of Arts, University of Hong Kong

Award Date: 1 Jan 1983


  • QD Chemistry
  • Biochemistry
  • X-ray Crystallography
  • Structural Biology
  • Biophysics
  • Neurodegeneration


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