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Yun Ma

Dr

    • 6317
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    Personal profile

    Research interests

    My main research interests are defining the pathegenesis of autoimmune liver diseases (AILD) in both children and adults, characterising the defects leading to immunotolerance breaks down in AILD, and defining the genetic association with AILD, including HLA and non-HLA genes. In addition to isolating and identifying novel autoantigens (alcohol dehydrogenage and soluble liver antigen) in the past, I have defined immunodominant epitopes on one of the major autoantigens, cytochrome P450 2D6 (CYP2D6) for CD4 and CD8 T cells. These epitopes have been used to isolate and expand autoantigen specific CD4+CD25+ regulatory T cells (Tregs), which are numerically and functionally defected in AILD. I have also used CYP2D6 to establish two novel mouse models of AILD, in which the disease risk genes, HLA DR3 and -DR4, are carried by these mice, facilitating the immunotelerance breaks down in the liver. I have also investigated immunological aspects in liver transplatation, promoting the latest technigue of liver graft presevation, nornmothermic machine perfusion (NMP). The final goal of my research is to restore immunotolerance in the lvier through the application of immunoregulatory therapies to treatment AILD and also to induce liver graft acceptance. 

    Research interests (short)

    Immunoregulation; immunogenetics; pathogenesis of autoimmune liver diseases, transplation immunology

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

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