β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces

S Terbeck; G Kahane; S McTavish; R McCutcheon; M Hewstone; J Savulescu; L P Chesterman; P J Cowen; R Norbury

doi:10.1007/s00213-015-3929-7

β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces

S Terbeck, G Kahane, S McTavish, R McCutcheon, M Hewstone, J Savulescu, L P Chesterman, P J Cowen, R Norbury

Psychosis Studies

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Abstract

INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias.

MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race.

RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure.

CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus.

Original language	English
Pages (from-to)	2951-2958
Number of pages	8
Journal	Psychopharmacology
Volume	232
Issue number	16
Early online date	22 Apr 2015
DOIs	https://doi.org/10.1007/s00213-015-3929-7
Publication status	Published - Aug 2015

Keywords

Adrenergic beta-Antagonists
African Americans
Attitude
Double-Blind Method
European Continental Ancestry Group
Face
Female
Humans
Magnetic Resonance Imaging
Male
Photic Stimulation
Prejudice
Propranolol
Temporal Lobe
Young Adult

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β-Adrenoceptor blockade modulates_TERBECK_Accepted 30Mar2015_GOLD VoR
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Cite this

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title = "β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces",

abstract = "INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias.MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race.RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure.CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus.",

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author = "S Terbeck and G Kahane and S McTavish and R McCutcheon and M Hewstone and J Savulescu and Chesterman, {L P} and Cowen, {P J} and R Norbury",

year = "2015",

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doi = "10.1007/s00213-015-3929-7",

language = "English",

volume = "232",

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T1 - β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces

AU - Terbeck, S

AU - Kahane, G

AU - McTavish, S

AU - McCutcheon, R

AU - Hewstone, M

AU - Savulescu, J

AU - Chesterman, L P

AU - Cowen, P J

AU - Norbury, R

PY - 2015/8

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N2 - INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias.MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race.RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure.CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus.

AB - INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias.MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race.RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure.CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus.

KW - Adrenergic beta-Antagonists

KW - African Americans

KW - Attitude

KW - Double-Blind Method

KW - European Continental Ancestry Group

KW - Face

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Photic Stimulation

KW - Prejudice

KW - Propranolol

KW - Temporal Lobe

KW - Young Adult

U2 - 10.1007/s00213-015-3929-7

DO - 10.1007/s00213-015-3929-7

M3 - Article

C2 - 25899791

SN - 0033-3158

VL - 232

SP - 2951

EP - 2958

JO - Psychopharmacology

JF - Psychopharmacology

IS - 16

ER -

β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces

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Keywords

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