λ-Eye: A high-sensitivity γ imaging probe for axillary sentinel lymph node mapping

Maria Georgiou; George Loudos; Eleftherios Fysikopoulos; Efthimis Lamprou; Kwnstantinos Mikropoulos; Antonio Shegani; Panagiotis Georgoulias

doi:10.1097/MNM.0000000000000546

λ-Eye: A high-sensitivity γ imaging probe for axillary sentinel lymph node mapping

Maria Georgiou^*, George Loudos, Eleftherios Fysikopoulos, Efthimis Lamprou, Kwnstantinos Mikropoulos, Antonio Shegani, Panagiotis Georgoulias

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective The aim of this study is the construction and performance evaluation of γ-eye, a γ imaging probe, optimized in terms of sensitivity for sentinel lymph node mapping. The optimization of the probe is based on theoretical models and simulation results that were presented in a previous study of our group. In this work, the construction of the probe, the experimental confirmation of the simulation results, and the evaluation of its performance with phantoms and lymph node imaging in small animals are presented. Methods The systems spatial and energy resolution, sensitivity, and count rate performance were measured using phantoms. The values of the integral and differential uniformity in the useful field-of-view and in the central fieldof-view were also calculated. Finally, a proof-of-concept animal experiment was conducted for the imaging of the lymph nodes of normal mice. Results The systems energy resolution was measured as 36± 2% and the spatial resolution was 2.2mm at 2mm source-collimator distance. The values of the integral uniformity and differential uniformity in the useful field-ofview and in the central field-of-view were found to be 5.2, 2.1, 1.7, and 0.75%, respectively. Finally, the lymph nodes of normal mice were clearly imaged with a 10 s acquisition time. Conclusion The γ-eye, used for sentinel lymph node mapping, provides a combination of high sensitivity (∼1.5 counts/s/kBq) and good spatial resolution (∼6mm full-width of the half-maximum at 20mm and ∼10mm fullwidth of the half-maximum at 50mm distance). Its compact size (40mm×40mm×70 mm) allows its use during surgery and/or for the detailed scan of a suspicious region.

Original language	English
Pages (from-to)	1001-1009
Number of pages	9
Journal	Nuclear Medicine Communications
Volume	37
Issue number	10
DOIs	https://doi.org/10.1097/MNM.0000000000000546
Publication status	Published - 1 Jan 2016

Keywords

High sensitivity
Position-sensitive photomultipliers
Sentinel lymph node
Sentinel lymph node biopsy
γ imaging
Γ probe
λ-eye

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10.1097/MNM.0000000000000546

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@article{3f30e1680a0b4fd59b288e62fd7a6474,

title = "λ-Eye: A high-sensitivity γ imaging probe for axillary sentinel lymph node mapping",

abstract = "Objective The aim of this study is the construction and performance evaluation of γ-eye, a γ imaging probe, optimized in terms of sensitivity for sentinel lymph node mapping. The optimization of the probe is based on theoretical models and simulation results that were presented in a previous study of our group. In this work, the construction of the probe, the experimental confirmation of the simulation results, and the evaluation of its performance with phantoms and lymph node imaging in small animals are presented. Methods The systems spatial and energy resolution, sensitivity, and count rate performance were measured using phantoms. The values of the integral and differential uniformity in the useful field-of-view and in the central fieldof-view were also calculated. Finally, a proof-of-concept animal experiment was conducted for the imaging of the lymph nodes of normal mice. Results The systems energy resolution was measured as 36± 2% and the spatial resolution was 2.2mm at 2mm source-collimator distance. The values of the integral uniformity and differential uniformity in the useful field-ofview and in the central field-of-view were found to be 5.2, 2.1, 1.7, and 0.75%, respectively. Finally, the lymph nodes of normal mice were clearly imaged with a 10 s acquisition time. Conclusion The γ-eye, used for sentinel lymph node mapping, provides a combination of high sensitivity (∼1.5 counts/s/kBq) and good spatial resolution (∼6mm full-width of the half-maximum at 20mm and ∼10mm fullwidth of the half-maximum at 50mm distance). Its compact size (40mm×40mm×70 mm) allows its use during surgery and/or for the detailed scan of a suspicious region.",

keywords = "High sensitivity, Position-sensitive photomultipliers, Sentinel lymph node, Sentinel lymph node biopsy, γ imaging, Γ probe, λ-eye",

author = "Maria Georgiou and George Loudos and Eleftherios Fysikopoulos and Efthimis Lamprou and Kwnstantinos Mikropoulos and Antonio Shegani and Panagiotis Georgoulias",

year = "2016",

month = jan,

day = "1",

doi = "10.1097/MNM.0000000000000546",

language = "English",

volume = "37",

pages = "1001--1009",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

publisher = "Lippincott Williams and Wilkins",

number = "10",

}

TY - JOUR

T1 - λ-Eye

T2 - A high-sensitivity γ imaging probe for axillary sentinel lymph node mapping

AU - Georgiou, Maria

AU - Loudos, George

AU - Fysikopoulos, Eleftherios

AU - Lamprou, Efthimis

AU - Mikropoulos, Kwnstantinos

AU - Shegani, Antonio

AU - Georgoulias, Panagiotis

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective The aim of this study is the construction and performance evaluation of γ-eye, a γ imaging probe, optimized in terms of sensitivity for sentinel lymph node mapping. The optimization of the probe is based on theoretical models and simulation results that were presented in a previous study of our group. In this work, the construction of the probe, the experimental confirmation of the simulation results, and the evaluation of its performance with phantoms and lymph node imaging in small animals are presented. Methods The systems spatial and energy resolution, sensitivity, and count rate performance were measured using phantoms. The values of the integral and differential uniformity in the useful field-of-view and in the central fieldof-view were also calculated. Finally, a proof-of-concept animal experiment was conducted for the imaging of the lymph nodes of normal mice. Results The systems energy resolution was measured as 36± 2% and the spatial resolution was 2.2mm at 2mm source-collimator distance. The values of the integral uniformity and differential uniformity in the useful field-ofview and in the central field-of-view were found to be 5.2, 2.1, 1.7, and 0.75%, respectively. Finally, the lymph nodes of normal mice were clearly imaged with a 10 s acquisition time. Conclusion The γ-eye, used for sentinel lymph node mapping, provides a combination of high sensitivity (∼1.5 counts/s/kBq) and good spatial resolution (∼6mm full-width of the half-maximum at 20mm and ∼10mm fullwidth of the half-maximum at 50mm distance). Its compact size (40mm×40mm×70 mm) allows its use during surgery and/or for the detailed scan of a suspicious region.

AB - Objective The aim of this study is the construction and performance evaluation of γ-eye, a γ imaging probe, optimized in terms of sensitivity for sentinel lymph node mapping. The optimization of the probe is based on theoretical models and simulation results that were presented in a previous study of our group. In this work, the construction of the probe, the experimental confirmation of the simulation results, and the evaluation of its performance with phantoms and lymph node imaging in small animals are presented. Methods The systems spatial and energy resolution, sensitivity, and count rate performance were measured using phantoms. The values of the integral and differential uniformity in the useful field-of-view and in the central fieldof-view were also calculated. Finally, a proof-of-concept animal experiment was conducted for the imaging of the lymph nodes of normal mice. Results The systems energy resolution was measured as 36± 2% and the spatial resolution was 2.2mm at 2mm source-collimator distance. The values of the integral uniformity and differential uniformity in the useful field-ofview and in the central field-of-view were found to be 5.2, 2.1, 1.7, and 0.75%, respectively. Finally, the lymph nodes of normal mice were clearly imaged with a 10 s acquisition time. Conclusion The γ-eye, used for sentinel lymph node mapping, provides a combination of high sensitivity (∼1.5 counts/s/kBq) and good spatial resolution (∼6mm full-width of the half-maximum at 20mm and ∼10mm fullwidth of the half-maximum at 50mm distance). Its compact size (40mm×40mm×70 mm) allows its use during surgery and/or for the detailed scan of a suspicious region.

KW - High sensitivity

KW - Position-sensitive photomultipliers

KW - Sentinel lymph node

KW - Sentinel lymph node biopsy

KW - γ imaging

KW - Γ probe

KW - λ-eye

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U2 - 10.1097/MNM.0000000000000546

DO - 10.1097/MNM.0000000000000546

M3 - Article

C2 - 27191937

AN - SCOPUS:84969180481

SN - 0143-3636

VL - 37

SP - 1001

EP - 1009

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 10

ER -

λ-Eye: A high-sensitivity γ imaging probe for axillary sentinel lymph node mapping

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