102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

Lin He; Tao Li; Claire Melville; Sheng Liu; Guo-Ying Feng; Niu-Fan Gu; Helen Fox; Duncan Shaw; Gerome Breen; Xiehe Liu; Pak Sham; John Brown; David Collier; David St Clair

102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

Lin He, Tao Li, Claire Melville, Sheng Liu, Guo-Ying Feng, Niu-Fan Gu, Helen Fox, Duncan Shaw, Gerome Breen, Xiehe Liu, Pak Sham, John Brown, David Collier, David St Clair

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Abstract

Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.

Original language	Undefined/Unknown
Article number	N/A
Pages (from-to)	95-98
Number of pages	4
Journal	American Journal of Medical Genetics
Volume	88
Issue number	1
Publication status	Published - 5 Feb 1999

Cite this

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title = "102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations",

abstract = "Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.",

author = "Lin He and Tao Li and Claire Melville and Sheng Liu and Guo-Ying Feng and Niu-Fan Gu and Helen Fox and Duncan Shaw and Gerome Breen and Xiehe Liu and Pak Sham and John Brown and David Collier and {St Clair}, David",

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journal = "American Journal of Medical Genetics",

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T1 - 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

AU - He, Lin

AU - Li, Tao

AU - Melville, Claire

AU - Liu, Sheng

AU - Feng, Guo-Ying

AU - Gu, Niu-Fan

AU - Fox, Helen

AU - Shaw, Duncan

AU - Breen, Gerome

AU - Liu, Xiehe

AU - Sham, Pak

AU - Brown, John

AU - Collier, David

AU - St Clair, David

PY - 1999/2/5

Y1 - 1999/2/5

N2 - Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.

AB - Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres.

M3 - Article

VL - 88

SP - 95

EP - 98

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

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