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[11C]CO2 to [11C]CO conversion mediated by [11C]silanes: A novel route for [11C] carbonylation reactions

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)11795-11797
Number of pages3
JournalChemical communications (Cambridge, England)
Volume51
Issue number59
DOIs
Publication statusPublished - 28 Jul 2015

King's Authors

Abstract

A novel chemical methodology is described for the conversion of [11C]CO2 to [11C]CO. Diphenylmethyl silanes trap [11C]CO2 and release [11C]CO rapidly when triggered by TBAF. Released[11C]CO was used to produce [11C]N-benzylbenzamide and AMPA receptor ligand, [11C]CX546, in radiochemical yields >90% within 6 min from [11C]CO2 production.

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