12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder

the BASIS TEAM

doi:10.1016/j.dcn.2021.100938

12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder

the BASIS TEAM

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD

Original language	English
Article number	100938
Journal	Developmental Cognitive Neuroscience
Volume	48
DOIs	https://doi.org/10.1016/j.dcn.2021.100938
Publication status	Published - Apr 2021

Keywords

Autism spectrum disorder
Cognitive development
EEG
Infant siblings
Peak alpha frequency

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10.1016/j.dcn.2021.100938

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@article{d75f7ac2d7be4851b6bab847bb7cfe2f,

title = "12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder",

abstract = "Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD",

keywords = "Autism spectrum disorder, Cognitive development, EEG, Infant siblings, Peak alpha frequency",

author = "{the BASIS TEAM} and {Carter Leno}, Virginia and Andrew Pickles and {van Noordt}, Stefon and Scott Huberty and James Desjardins and Webb, {Sara Jane} and Mayada Elsabbagh",

note = "Funding Information: BASIS data were collected with support from the UK Medical Research Council and Autistica . The authors acknowledge the following sources of funding: NIMH ( U19 MH108206 ), NIH ( P50 HD055782 ), Autism Science Foundation, Autism Speaks (SW); Azrieli Centre for Autism Research (MA); Quebec Autism Research Trainee award provided by the Transforming Autism Care Consortium (TACC) (SH, SvN); NIHR ( NF-SI-0617-10120 ) and Biomedical Research Centre at South London , and Maudsley NHS Foundation Trust and King{\textquoteright}s College London (AP); Sir Henry Wellcome Postdoctoral Fellowship ( 213608/Z/18/Z ) (VCL). Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = apr,

doi = "10.1016/j.dcn.2021.100938",

language = "English",

volume = "48",

journal = "Developmental Cognitive Neuroscience",

issn = "1878-9293",

publisher = "Elsevier BV",

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TY - JOUR

T1 - 12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder

AU - the BASIS TEAM

AU - Carter Leno, Virginia

AU - Pickles, Andrew

AU - van Noordt, Stefon

AU - Huberty, Scott

AU - Desjardins, James

AU - Webb, Sara Jane

AU - Elsabbagh, Mayada

N1 - Funding Information: BASIS data were collected with support from the UK Medical Research Council and Autistica . The authors acknowledge the following sources of funding: NIMH ( U19 MH108206 ), NIH ( P50 HD055782 ), Autism Science Foundation, Autism Speaks (SW); Azrieli Centre for Autism Research (MA); Quebec Autism Research Trainee award provided by the Transforming Autism Care Consortium (TACC) (SH, SvN); NIHR ( NF-SI-0617-10120 ) and Biomedical Research Centre at South London , and Maudsley NHS Foundation Trust and King’s College London (AP); Sir Henry Wellcome Postdoctoral Fellowship ( 213608/Z/18/Z ) (VCL). Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD

AB - Although studies of PAF in individuals with autism spectrum disorder (ASD) report group differences and associations with non-verbal cognitive ability, it is not known how PAF relates to familial risk for ASD, and whether similar associations with cognition in are present in infancy. Using a large multi-site prospective longitudinal dataset of infants with low and high familial risk for ASD, metrics of PAF at 12 months were extracted and growth curves estimated for cognitive development between 12–36 months. Analyses tested whether PAF 1) differs between low and high risk infants, 2) is associated with concurrent non-verbal/verbal cognitive ability and 3) predicts developmental change in non-verbal/verbal ability. Moderation of associations between PAF and cognitive ability by familial risk status was also tested. No differences in 12-month PAF were found between low and high risk infants. PAF was associated with concurrent non-verbal cognitive ability, but did not predict change in non-verbal cognitive over development. No associations were found between PAF and verbal ability, along with no evidence of moderation. PAF is not related to familial risk for ASD, and is a neural marker of concurrent non-verbal cognitive ability, but not verbal ability, in young infants at low and high risk for ASD

KW - Autism spectrum disorder

KW - Cognitive development

KW - EEG

KW - Infant siblings

KW - Peak alpha frequency

UR - http://www.scopus.com/inward/record.url?scp=85102964724&partnerID=8YFLogxK

U2 - 10.1016/j.dcn.2021.100938

DO - 10.1016/j.dcn.2021.100938

M3 - Article

C2 - 33714056

AN - SCOPUS:85102964724

SN - 1878-9293

VL - 48

JO - Developmental Cognitive Neuroscience

JF - Developmental Cognitive Neuroscience

M1 - 100938

ER -

12-Month peak alpha frequency is a correlate but not a longitudinal predictor of non-verbal cognitive abilities in infants at low and high risk for autism spectrum disorder

Abstract

Keywords

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