[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

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Abstract

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.
Original languageEnglish
Pages (from-to)843-854
Number of pages12
JournalTomography
Volume7
Issue number4
Early online date1 Dec 2021
DOIs
Publication statusPublished - 1 Dec 2021

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