[18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

TY - JOUR

T1 - [18F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging

AU - Puri, Tanuj

AU - Frost, Michelle

AU - Cook, Gary

AU - Blake, Glen

N1 - Funding Information: The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy?s and St Thomas? NHS Foundation Trust and King?s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

AB - This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([18F]NaF) to understand bone physiology. Dynamic [18F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

UR - http://www.scopus.com/inward/record.url?scp=85121838664&partnerID=8YFLogxK

U2 - 10.3390/tomography7040071

DO - 10.3390/tomography7040071

M3 - Review article

SN - 2379-1381

VL - 7

SP - 843

EP - 854

JO - Tomography

JF - Tomography

IS - 4

ER -