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2D:4D ratio in children at familial high-risk for eating disorders: The role of prenatal testosterone exposure

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2D:4D ratio in children at familial high-risk for eating disorders : The role of prenatal testosterone exposure. / Kothari, Radha; Gafton, Joseph; Treasure, Janet; Micali, Nadia.

In: AMERICAN JOURNAL OF HUMAN BIOLOGY, Vol. 26, No. 2, 03.2014, p. 176-182.

Research output: Contribution to journalArticle

Harvard

Kothari, R, Gafton, J, Treasure, J & Micali, N 2014, '2D:4D ratio in children at familial high-risk for eating disorders: The role of prenatal testosterone exposure', AMERICAN JOURNAL OF HUMAN BIOLOGY, vol. 26, no. 2, pp. 176-182. https://doi.org/10.1002/ajhb.22495

APA

Kothari, R., Gafton, J., Treasure, J., & Micali, N. (2014). 2D:4D ratio in children at familial high-risk for eating disorders: The role of prenatal testosterone exposure. AMERICAN JOURNAL OF HUMAN BIOLOGY, 26(2), 176-182. https://doi.org/10.1002/ajhb.22495

Vancouver

Kothari R, Gafton J, Treasure J, Micali N. 2D:4D ratio in children at familial high-risk for eating disorders: The role of prenatal testosterone exposure. AMERICAN JOURNAL OF HUMAN BIOLOGY. 2014 Mar;26(2):176-182. https://doi.org/10.1002/ajhb.22495

Author

Kothari, Radha ; Gafton, Joseph ; Treasure, Janet ; Micali, Nadia. / 2D:4D ratio in children at familial high-risk for eating disorders : The role of prenatal testosterone exposure. In: AMERICAN JOURNAL OF HUMAN BIOLOGY. 2014 ; Vol. 26, No. 2. pp. 176-182.

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@article{4940f69de364485db570a6a810baa8cf,
title = "2D:4D ratio in children at familial high-risk for eating disorders: The role of prenatal testosterone exposure",
abstract = "ObjectivesMarkers of prenatal hormone exposure have been associated with the development of eating disorder (ED) behaviors. Our aim was to determine whether 2D:4D ratio, a marker for in utero testosterone exposure, is associated with risk for ED in a large population-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: This is the first study to investigate prenatal testosterone exposure in children at high-risk for ED, using 2D:4D as a marker. We compared children whose mothers reported a lifetime ED (anorexia, bulimia, or both; N = 446) to children whose mothers did not (n = 5,367). Results: Daughters of women with lifetime bulimia nervosa (BN) had lower 2D:4D ratio (B: −0.01, 95{\%} CI: −0.02 to −0.002, P = 0.02), indicating higher prenatal testosterone exposure, than daughters of mothers unaffected by ED. No differences were observed in the male children of women with an ED. Conclusions: Findings suggest that children at high-risk for BN may be exposed to higher levels of testosterone in utero. Fetal exposure to androgen excess is thought to be causal in the development of polycystic ovary syndrome (PCOS), a disorder which is highly comorbid with binge eating and BN. Future research should investigate the potential role of testosterone exposure in utero as a risk factor for BN and binge eating.",
author = "Radha Kothari and Joseph Gafton and Janet Treasure and Nadia Micali",
year = "2014",
month = "3",
doi = "10.1002/ajhb.22495",
language = "English",
volume = "26",
pages = "176--182",
journal = "AMERICAN JOURNAL OF HUMAN BIOLOGY",
issn = "1042-0533",
publisher = "Wiley-Liss Inc.",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - 2D:4D ratio in children at familial high-risk for eating disorders

T2 - The role of prenatal testosterone exposure

AU - Kothari, Radha

AU - Gafton, Joseph

AU - Treasure, Janet

AU - Micali, Nadia

PY - 2014/3

Y1 - 2014/3

N2 - ObjectivesMarkers of prenatal hormone exposure have been associated with the development of eating disorder (ED) behaviors. Our aim was to determine whether 2D:4D ratio, a marker for in utero testosterone exposure, is associated with risk for ED in a large population-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: This is the first study to investigate prenatal testosterone exposure in children at high-risk for ED, using 2D:4D as a marker. We compared children whose mothers reported a lifetime ED (anorexia, bulimia, or both; N = 446) to children whose mothers did not (n = 5,367). Results: Daughters of women with lifetime bulimia nervosa (BN) had lower 2D:4D ratio (B: −0.01, 95% CI: −0.02 to −0.002, P = 0.02), indicating higher prenatal testosterone exposure, than daughters of mothers unaffected by ED. No differences were observed in the male children of women with an ED. Conclusions: Findings suggest that children at high-risk for BN may be exposed to higher levels of testosterone in utero. Fetal exposure to androgen excess is thought to be causal in the development of polycystic ovary syndrome (PCOS), a disorder which is highly comorbid with binge eating and BN. Future research should investigate the potential role of testosterone exposure in utero as a risk factor for BN and binge eating.

AB - ObjectivesMarkers of prenatal hormone exposure have been associated with the development of eating disorder (ED) behaviors. Our aim was to determine whether 2D:4D ratio, a marker for in utero testosterone exposure, is associated with risk for ED in a large population-based cohort: the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: This is the first study to investigate prenatal testosterone exposure in children at high-risk for ED, using 2D:4D as a marker. We compared children whose mothers reported a lifetime ED (anorexia, bulimia, or both; N = 446) to children whose mothers did not (n = 5,367). Results: Daughters of women with lifetime bulimia nervosa (BN) had lower 2D:4D ratio (B: −0.01, 95% CI: −0.02 to −0.002, P = 0.02), indicating higher prenatal testosterone exposure, than daughters of mothers unaffected by ED. No differences were observed in the male children of women with an ED. Conclusions: Findings suggest that children at high-risk for BN may be exposed to higher levels of testosterone in utero. Fetal exposure to androgen excess is thought to be causal in the development of polycystic ovary syndrome (PCOS), a disorder which is highly comorbid with binge eating and BN. Future research should investigate the potential role of testosterone exposure in utero as a risk factor for BN and binge eating.

U2 - 10.1002/ajhb.22495

DO - 10.1002/ajhb.22495

M3 - Article

C2 - 24323736

VL - 26

SP - 176

EP - 182

JO - AMERICAN JOURNAL OF HUMAN BIOLOGY

JF - AMERICAN JOURNAL OF HUMAN BIOLOGY

SN - 1042-0533

IS - 2

ER -

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