3D B1+ corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation

Haikun Qi; Zhenfeng Lv; Jiameng Diao; Xiaofeng Tao; Junpu Hu; Jian Xu; René Botnar; Claudia Prieto; Peng Hu

doi:10.1002/mrm.30317

3D B1+ corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation

Haikun Qi^*, Zhenfeng Lv, Jiameng Diao, Xiaofeng Tao, Junpu Hu, Jian Xu, René Botnar, Claudia Prieto, Peng Hu

^*Corresponding author for this work

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To develop a 3D free-breathing cardiac multi-parametric mapping framework that is robust to confounders of respiratory motion, fat, and B1+ inhomogeneities and validate it for joint myocardial T1 and T1ρ mapping at 3T. Methods: An electrocardiogram-triggered sequence with dual-echo Dixon readout was developed, where nine cardiac cycles were repeatedly acquired with inversion recovery and T1ρ preparation pulses for T1 and T1ρ sensitization. A subject-specific respiratory motion model relating the 1D diaphragmatic navigator to the respiration-induced 3D translational motion of the heart was constructed followed by respiratory motion binning and intra-bin 3D translational and inter-bin non-rigid motion correction. Spin history B1+ inhomogeneities were corrected with optimized dual flip angle strategy. After water-fat separation, the water images were matched to the simulated dictionary for T1 and T1ρ quantification. Phantoms and 10 heathy subjects were imaged to validate the proposed technique. Results: The proposed technique achieved strong correlation (T1: R² = 0.99; T1ρ: R² = 0.98) with the reference measurements in phantoms. 3D cardiac T1 and T1ρ maps with spatial resolution of 2 × 2 × 4 mm were obtained with scan time of 5.4 ± 0.5 min, demonstrating comparable T1 (1236 ± 59 ms) and T1ρ (50.2 ± 2.4 ms) measurements to 2D separate breath-hold mapping techniques. The estimated B1+ maps showed spatial variations across the left ventricle with the septal and inferior regions being 10%–25% lower than the anterior and septal regions. Conclusion: The proposed technique achieved efficient 3D joint myocardial T1 and T1ρ mapping at 3T with respiratory motion correction, spin history B1+ correction and water-fat separation.

Original language	English
Pages (from-to)	751-760
Number of pages	10
Journal	Magnetic Resonance in Medicine
Volume	93
Issue number	2
DOIs	https://doi.org/10.1002/mrm.30317
Publication status	Published - Feb 2025

Keywords

B1+ correction
cardiac multi-parametric mapping
free-breathing
T1 mapping
T1ρ mapping

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10.1002/mrm.30317

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@article{76811a9e3cdb4b51ad76bfe562924080,

title = "3D B1+ corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation",

abstract = "Purpose: To develop a 3D free-breathing cardiac multi-parametric mapping framework that is robust to confounders of respiratory motion, fat, and B1+ inhomogeneities and validate it for joint myocardial T1 and T1ρ mapping at 3T. Methods: An electrocardiogram-triggered sequence with dual-echo Dixon readout was developed, where nine cardiac cycles were repeatedly acquired with inversion recovery and T1ρ preparation pulses for T1 and T1ρ sensitization. A subject-specific respiratory motion model relating the 1D diaphragmatic navigator to the respiration-induced 3D translational motion of the heart was constructed followed by respiratory motion binning and intra-bin 3D translational and inter-bin non-rigid motion correction. Spin history B1+ inhomogeneities were corrected with optimized dual flip angle strategy. After water-fat separation, the water images were matched to the simulated dictionary for T1 and T1ρ quantification. Phantoms and 10 heathy subjects were imaged to validate the proposed technique. Results: The proposed technique achieved strong correlation (T1: R2 = 0.99; T1ρ: R2 = 0.98) with the reference measurements in phantoms. 3D cardiac T1 and T1ρ maps with spatial resolution of 2 × 2 × 4 mm were obtained with scan time of 5.4 ± 0.5 min, demonstrating comparable T1 (1236 ± 59 ms) and T1ρ (50.2 ± 2.4 ms) measurements to 2D separate breath-hold mapping techniques. The estimated B1+ maps showed spatial variations across the left ventricle with the septal and inferior regions being 10%–25% lower than the anterior and septal regions. Conclusion: The proposed technique achieved efficient 3D joint myocardial T1 and T1ρ mapping at 3T with respiratory motion correction, spin history B1+ correction and water-fat separation.",

keywords = "B1+ correction, cardiac multi-parametric mapping, free-breathing, T1 mapping, T1ρ mapping",

author = "Haikun Qi and Zhenfeng Lv and Jiameng Diao and Xiaofeng Tao and Junpu Hu and Jian Xu and Ren{\'e} Botnar and Claudia Prieto and Peng Hu",

note = "Publisher Copyright: {\textcopyright} 2024 International Society for Magnetic Resonance in Medicine.",

year = "2025",

month = feb,

doi = "10.1002/mrm.30317",

language = "English",

volume = "93",

pages = "751--760",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "WILEY-BLACKWELL",

number = "2",

}

TY - JOUR

T1 - 3D B1+ corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation

AU - Qi, Haikun

AU - Lv, Zhenfeng

AU - Diao, Jiameng

AU - Tao, Xiaofeng

AU - Hu, Junpu

AU - Xu, Jian

AU - Botnar, René

AU - Prieto, Claudia

AU - Hu, Peng

PY - 2025/2

Y1 - 2025/2

N2 - Purpose: To develop a 3D free-breathing cardiac multi-parametric mapping framework that is robust to confounders of respiratory motion, fat, and B1+ inhomogeneities and validate it for joint myocardial T1 and T1ρ mapping at 3T. Methods: An electrocardiogram-triggered sequence with dual-echo Dixon readout was developed, where nine cardiac cycles were repeatedly acquired with inversion recovery and T1ρ preparation pulses for T1 and T1ρ sensitization. A subject-specific respiratory motion model relating the 1D diaphragmatic navigator to the respiration-induced 3D translational motion of the heart was constructed followed by respiratory motion binning and intra-bin 3D translational and inter-bin non-rigid motion correction. Spin history B1+ inhomogeneities were corrected with optimized dual flip angle strategy. After water-fat separation, the water images were matched to the simulated dictionary for T1 and T1ρ quantification. Phantoms and 10 heathy subjects were imaged to validate the proposed technique. Results: The proposed technique achieved strong correlation (T1: R2 = 0.99; T1ρ: R2 = 0.98) with the reference measurements in phantoms. 3D cardiac T1 and T1ρ maps with spatial resolution of 2 × 2 × 4 mm were obtained with scan time of 5.4 ± 0.5 min, demonstrating comparable T1 (1236 ± 59 ms) and T1ρ (50.2 ± 2.4 ms) measurements to 2D separate breath-hold mapping techniques. The estimated B1+ maps showed spatial variations across the left ventricle with the septal and inferior regions being 10%–25% lower than the anterior and septal regions. Conclusion: The proposed technique achieved efficient 3D joint myocardial T1 and T1ρ mapping at 3T with respiratory motion correction, spin history B1+ correction and water-fat separation.

AB - Purpose: To develop a 3D free-breathing cardiac multi-parametric mapping framework that is robust to confounders of respiratory motion, fat, and B1+ inhomogeneities and validate it for joint myocardial T1 and T1ρ mapping at 3T. Methods: An electrocardiogram-triggered sequence with dual-echo Dixon readout was developed, where nine cardiac cycles were repeatedly acquired with inversion recovery and T1ρ preparation pulses for T1 and T1ρ sensitization. A subject-specific respiratory motion model relating the 1D diaphragmatic navigator to the respiration-induced 3D translational motion of the heart was constructed followed by respiratory motion binning and intra-bin 3D translational and inter-bin non-rigid motion correction. Spin history B1+ inhomogeneities were corrected with optimized dual flip angle strategy. After water-fat separation, the water images were matched to the simulated dictionary for T1 and T1ρ quantification. Phantoms and 10 heathy subjects were imaged to validate the proposed technique. Results: The proposed technique achieved strong correlation (T1: R2 = 0.99; T1ρ: R2 = 0.98) with the reference measurements in phantoms. 3D cardiac T1 and T1ρ maps with spatial resolution of 2 × 2 × 4 mm were obtained with scan time of 5.4 ± 0.5 min, demonstrating comparable T1 (1236 ± 59 ms) and T1ρ (50.2 ± 2.4 ms) measurements to 2D separate breath-hold mapping techniques. The estimated B1+ maps showed spatial variations across the left ventricle with the septal and inferior regions being 10%–25% lower than the anterior and septal regions. Conclusion: The proposed technique achieved efficient 3D joint myocardial T1 and T1ρ mapping at 3T with respiratory motion correction, spin history B1+ correction and water-fat separation.

KW - B1+ correction

KW - cardiac multi-parametric mapping

KW - free-breathing

KW - T1 mapping

KW - T1ρ mapping

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U2 - 10.1002/mrm.30317

DO - 10.1002/mrm.30317

M3 - Article

C2 - 39370883

AN - SCOPUS:85205894283

SN - 0740-3194

VL - 93

SP - 751

EP - 760

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -

3D B1+ corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation

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