Abstract
Purpose: To develop a novel, free-breathing, 3D joint T1 /T1π/T2 mapping sequence with Dixon encoding to provide co-registered 3D T1 , T1π, and T2 maps and water-fat volumes with isotropic spatial resolution in a single β 7 min scan for comprehensive contrast-agent-free myocardial tissue characterization and simultaneous evaluation of the whole-heart anatomy.
Methods: An interleaving sequence over 5 heartbeats is proposed to provide T1 , T1π,and T2 encoding, with 3D data acquired with Dixon gradient-echo readout and 2Dimage navigators to enable 100% respiratory scan efficiency. Images were reconstructed with a non-rigid motion-corrected, low-rank patch-based reconstruction, and maps we regenerated through dictionary matching. The proposed sequence was compared against conventional 2D techniques in phantoms, 10 healthy subjects, and 1 patient.
Results: The proposed 3D T1 , T1π, and T2 measurements showed excellent correlation with 2D reference measurements in phantoms. For healthy subjects, the mapping values of septal myocardial tissue were T1 = 1060 Β± 48 ms, T1π = 48.1 Β± 3.9 ms, and T2 =44.2 Β± 3.2 ms for the proposed sequence, against T1 = 959 Β± 15 ms, T1π = 56.4 Β± 1.9 ms,and T2 = 47.3 Β± 1.5 ms for 2D MOLLI, 2D T1π-prep bSSFP and 2D T2 -prep bSSFP, respectively. Promising results were obtained when comparing the proposed mapping to 2D references in 1 patient with active myocarditis.
Conclusion: The proposed approach enables simultaneous 3D whole-heart jointT1 /T1π/T2 mapping and water/fat imaging in β 7 min scan time, demonstrating good agreement with conventional mapping techniques in phantoms and healthy subjects and promising results in 1 patient with suspected cardiovascular disease.
Methods: An interleaving sequence over 5 heartbeats is proposed to provide T1 , T1π,and T2 encoding, with 3D data acquired with Dixon gradient-echo readout and 2Dimage navigators to enable 100% respiratory scan efficiency. Images were reconstructed with a non-rigid motion-corrected, low-rank patch-based reconstruction, and maps we regenerated through dictionary matching. The proposed sequence was compared against conventional 2D techniques in phantoms, 10 healthy subjects, and 1 patient.
Results: The proposed 3D T1 , T1π, and T2 measurements showed excellent correlation with 2D reference measurements in phantoms. For healthy subjects, the mapping values of septal myocardial tissue were T1 = 1060 Β± 48 ms, T1π = 48.1 Β± 3.9 ms, and T2 =44.2 Β± 3.2 ms for the proposed sequence, against T1 = 959 Β± 15 ms, T1π = 56.4 Β± 1.9 ms,and T2 = 47.3 Β± 1.5 ms for 2D MOLLI, 2D T1π-prep bSSFP and 2D T2 -prep bSSFP, respectively. Promising results were obtained when comparing the proposed mapping to 2D references in 1 patient with active myocarditis.
Conclusion: The proposed approach enables simultaneous 3D whole-heart jointT1 /T1π/T2 mapping and water/fat imaging in β 7 min scan time, demonstrating good agreement with conventional mapping techniques in phantoms and healthy subjects and promising results in 1 patient with suspected cardiovascular disease.
| Original language | English |
|---|---|
| Pages (from-to) | 2297-2310 |
| Number of pages | 14 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 93 |
| Issue number | 6 |
| Early online date | 21 Feb 2025 |
| DOIs | |
| Publication status | E-pub ahead of print - 21 Feb 2025 |
