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3D myocardial T1 mapping using saturation recovery

Research output: Contribution to journalArticle

Original languageEnglish
JournalJournal of Magnetic Resonance Imaging
Publication statusPublished - 2 Feb 2017


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King's Authors


Purpose: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects. Materials and Methods: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8mm3. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols. Results: There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6±31 msec vs. 1123.6±8 msec, P=0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881±40 msec, 1181.3±32 msec, and 1153.6±28 msec respectively. Conclusion: The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1-mapping with T1 values in good agreement with the 2D SASHA and improved precision. Level of Evidence: 2 J. Magn. Reson. Imaging 2017

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