3D myocardial T1 mapping using saturation recovery

Giovanna Nordio; Markus Henningsson; Amedeo Chiribiri; Adriana D M Villa; Torben Schneider; René M. Botnar

doi:10.1002/jmri.25575

3D myocardial T₁ mapping using saturation recovery

Giovanna Nordio^*, Markus Henningsson, Amedeo Chiribiri, Adriana D M Villa, Torben Schneider, René M. Botnar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

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Abstract

Purpose: To propose a 3D quantitative high-resolution T₁ mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T₁ phantom and in healthy subjects. Materials and Methods: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8mm³. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T₁ phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols. Results: There was good agreement between the T₁ values measured in a T₁ phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6±31 msec vs. 1123.6±8 msec, P=0.9947). Mean and standard deviation of the myocardial T₁ values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881±40 msec, 1181.3±32 msec, and 1153.6±28 msec respectively. Conclusion: The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T₁-mapping with T₁ values in good agreement with the 2D SASHA and improved precision. Level of Evidence: 2 J. Magn. Reson. Imaging 2017

Original language	English
Journal	Journal of Magnetic Resonance Imaging
DOIs	https://doi.org/10.1002/jmri.25575
Publication status	Published - 2 Feb 2017

Keywords

Accuracy
MRI
Precision
Saturation-recovery
T mapping

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "3D myocardial T1 mapping using saturation recovery",

abstract = "Purpose: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects. Materials and Methods: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8mm3. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols. Results: There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6±31 msec vs. 1123.6±8 msec, P=0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881±40 msec, 1181.3±32 msec, and 1153.6±28 msec respectively. Conclusion: The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1-mapping with T1 values in good agreement with the 2D SASHA and improved precision. Level of Evidence: 2 J. Magn. Reson. Imaging 2017",

keywords = "Accuracy, MRI, Precision, Saturation-recovery, T mapping",

author = "Giovanna Nordio and Markus Henningsson and Amedeo Chiribiri and Villa, {Adriana D M} and Torben Schneider and Botnar, {Ren{\'e} M.}",

note = "{\textcopyright} 2017 International Society for Magnetic Resonance in Medicine.",

year = "2017",

month = feb,

day = "2",

doi = "10.1002/jmri.25575",

language = "English",

journal = "Journal of Magnetic Resonance Imaging",

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T1 - 3D myocardial T1 mapping using saturation recovery

AU - Nordio, Giovanna

AU - Henningsson, Markus

AU - Chiribiri, Amedeo

AU - Villa, Adriana D M

AU - Schneider, Torben

AU - Botnar, René M.

PY - 2017/2/2

Y1 - 2017/2/2

N2 - Purpose: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects. Materials and Methods: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8mm3. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols. Results: There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6±31 msec vs. 1123.6±8 msec, P=0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881±40 msec, 1181.3±32 msec, and 1153.6±28 msec respectively. Conclusion: The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1-mapping with T1 values in good agreement with the 2D SASHA and improved precision. Level of Evidence: 2 J. Magn. Reson. Imaging 2017

AB - Purpose: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects. Materials and Methods: The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8mm3. For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols. Results: There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6±31 msec vs. 1123.6±8 msec, P=0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881±40 msec, 1181.3±32 msec, and 1153.6±28 msec respectively. Conclusion: The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1-mapping with T1 values in good agreement with the 2D SASHA and improved precision. Level of Evidence: 2 J. Magn. Reson. Imaging 2017

KW - Accuracy

KW - MRI

KW - Precision

KW - Saturation-recovery

KW - T mapping

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DO - 10.1002/jmri.25575

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C2 - 28152227

SN - 1522-2586

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

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