3D T (1)-mapping for the characterization of deep vein thrombosis

TY - JOUR

T1 - 3D T (1)-mapping for the characterization of deep vein thrombosis

AU - Blume, Ulrike

AU - Orbell, James

AU - Waltham, Matthew

AU - Smith, Alberto

AU - Razavi, Reza

AU - Schaeffter, Tobias

PY - 2009/12

Y1 - 2009/12

N2 - The aim of this work was to investigate fast T (1)-mapping for the characterization of deep vein thrombosis (DVT). The accuracy and reproducibility of the T (1)-mapping sequence was tested in phantoms and in 8 healthy volunteers on a 1.5 T clinical scanner using a 32-channel array coil. Furthermore, the feasibility of the technique was tested in 5 patients diagnosed with DVT by measuring the volume and T (1) values of the thrombus at 5 time points over a period of 6 months. The results of the phantom and volunteer study showed a high accuracy and reproducibility for the quantification of T (1). The resolution of the T (1)-maps was high enough to identify small anatomical structures. T (1) values derived for normal blood and various other tissues were comparable to those reported in the literature. In all patients, the T (1) times of thrombi showed decreased values (T (1) = 843 +/- A 91 ms) in the acute phase and recovered back to normal values of blood (T (1) = 1,317 +/- A 36 ms) after 6 months. Measurement of all relevant T (1) values of acute thrombi and normal blood achieved accurate and reproducible results in vivo. Fast T (1) quantification of the thrombus can provide information about tissue characteristics such as thrombus resolution. Such a quantitative MRI technique may be valuable in studying the factors that influence natural resolution and in evaluating treatment effects that enhance this process.

AB - The aim of this work was to investigate fast T (1)-mapping for the characterization of deep vein thrombosis (DVT). The accuracy and reproducibility of the T (1)-mapping sequence was tested in phantoms and in 8 healthy volunteers on a 1.5 T clinical scanner using a 32-channel array coil. Furthermore, the feasibility of the technique was tested in 5 patients diagnosed with DVT by measuring the volume and T (1) values of the thrombus at 5 time points over a period of 6 months. The results of the phantom and volunteer study showed a high accuracy and reproducibility for the quantification of T (1). The resolution of the T (1)-maps was high enough to identify small anatomical structures. T (1) values derived for normal blood and various other tissues were comparable to those reported in the literature. In all patients, the T (1) times of thrombi showed decreased values (T (1) = 843 +/- A 91 ms) in the acute phase and recovered back to normal values of blood (T (1) = 1,317 +/- A 36 ms) after 6 months. Measurement of all relevant T (1) values of acute thrombi and normal blood achieved accurate and reproducible results in vivo. Fast T (1) quantification of the thrombus can provide information about tissue characteristics such as thrombus resolution. Such a quantitative MRI technique may be valuable in studying the factors that influence natural resolution and in evaluating treatment effects that enhance this process.

U2 - 10.1007/s10334-009-0189-8

DO - 10.1007/s10334-009-0189-8

M3 - Article

SN - 1352-8661

VL - 22

SP - 375

EP - 383

JO - Magma: Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magma: Magnetic Resonance Materials in Physics, Biology and Medicine

IS - 6

ER -