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A 18F radiolabelled Zn(II) sensing fluorescent probe

Research output: Contribution to journalArticlepeer-review

Thomas W. Price, George Firth, Charlotte J. Eling, Michelle Kinnon, Nicholas J. Long, Justin Sturge, Graeme J. Stasiuk

Original languageEnglish
Pages (from-to)3227-3230
Number of pages4
JournalChemical Communications
Issue number26
Early online date5 Mar 2018
Accepted/In press5 Mar 2018
E-pub ahead of print5 Mar 2018
PublishedApr 2018


King's Authors


A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl2] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, Kd = 15.2 μM with Zn(ii). This probe has been shown to respond to endogenous Zn(ii) levels in vitro in prostate and prostate cancer cell lines. [18F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(ii).

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