A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [I-123]CNS 1261

R A Bressan; K Erlandsson; R S Mulligan; R N Gunn; V J Cunningham; J Owens; I D Cullum; P J Ell; L S Pilowsky

doi:10.1016/j.nucmedbio.2003.08.008

A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [I-123]CNS 1261

R A Bressan, K Erlandsson, R S Mulligan, R N Gunn, V J Cunningham, J Owens, I D Cullum, P J Ell, L S Pilowsky

King's College London

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [I-123]CNS 1261 in clinical populations. (C) 2004 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	155 - 164
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.nucmedbio.2003.08.008
Publication status	Published - Feb 2004

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10.1016/j.nucmedbio.2003.08.008

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title = "A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [I-123]CNS 1261",

abstract = "We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [I-123]CNS 1261 in clinical populations. (C) 2004 Elsevier Inc. All rights reserved.",

author = "Bressan, {R A} and K Erlandsson and Mulligan, {R S} and Gunn, {R N} and Cunningham, {V J} and J Owens and Cullum, {I D} and Ell, {P J} and Pilowsky, {L S}",

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language = "English",

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T1 - A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [I-123]CNS 1261

AU - Bressan, R A

AU - Erlandsson, K

AU - Mulligan, R S

AU - Gunn, R N

AU - Cunningham, V J

AU - Owens, J

AU - Cullum, I D

AU - Ell, P J

AU - Pilowsky, L S

PY - 2004/2

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AB - We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [I-123]CNS 1261 in clinical populations. (C) 2004 Elsevier Inc. All rights reserved.

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DO - 10.1016/j.nucmedbio.2003.08.008

M3 - Article

VL - 31

SP - 155

EP - 164

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 2

ER -

A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [I-123]CNS 1261

Abstract

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