A calibrated physical flow standard for medical perfusion imaging

TY - CONF

T1 - A calibrated physical flow standard for medical perfusion imaging

AU - Kok, G.

AU - Pelevic, N.

AU - Chiribiri, A.

AU - Milidonis, X.

AU - Nazir, M.

AU - Capstick, M.

AU - Drost, S.

AU - Poelma, C.

AU - Schaeffter, T.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In the medical sector, various imaging methodologies or modalities (e.g. MRI, PET, CT) are used to assess the health of various parts of the bodies of patients. One such investigation is the blood flow or perfusion of the heart muscle, expressed as the (blood) flow rate normalized by the mass of the volume of interest, with unit mL/min/g. Currently there is no physical flow standard for the assessment and validation of myocardial perfusion imaging methodologies, resulting in a large proportion of medical diagnoses being inaccurate and highly dependent on the scanner type, software used and the clinical operator. In the EMPIR 15HLT05 PerfusImaging project a phantom simulating myocardial perfusion has recently been developed with which imaging modalities can be tested. In this paper the construction and validation of the phantom is described which involved several iterations with design updates, computational fluid dynamics simulations, 3D printing of the phantom, ultrasound imaging velocimetry and magnetic resonance imaging (MRI). Dynamic contrast-enhanced MRI was performed to image the passage of a tracer through the phantom and estimate perfusion. Two flow models and associated data analysis methods to relate the measurement data with the reference flow rates are presented and discussed.

AB - In the medical sector, various imaging methodologies or modalities (e.g. MRI, PET, CT) are used to assess the health of various parts of the bodies of patients. One such investigation is the blood flow or perfusion of the heart muscle, expressed as the (blood) flow rate normalized by the mass of the volume of interest, with unit mL/min/g. Currently there is no physical flow standard for the assessment and validation of myocardial perfusion imaging methodologies, resulting in a large proportion of medical diagnoses being inaccurate and highly dependent on the scanner type, software used and the clinical operator. In the EMPIR 15HLT05 PerfusImaging project a phantom simulating myocardial perfusion has recently been developed with which imaging modalities can be tested. In this paper the construction and validation of the phantom is described which involved several iterations with design updates, computational fluid dynamics simulations, 3D printing of the phantom, ultrasound imaging velocimetry and magnetic resonance imaging (MRI). Dynamic contrast-enhanced MRI was performed to image the passage of a tracer through the phantom and estimate perfusion. Two flow models and associated data analysis methods to relate the measurement data with the reference flow rates are presented and discussed.

UR - http://www.scopus.com/inward/record.url?scp=85091440286&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:85091440286

T2 - 18th International Flow Measurement Conference, FLOMEKO 2019

Y2 - 26 June 2019 through 28 June 2019

ER -