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A CCD-based tissue imaging system

Research output: Contribution to journalArticlepeer-review

Original languageUndefined/Unknown
Pages (from-to)220-226
Number of pages7
JournalNuclear Instruments & Methods In Physics Research Section A, Accelerators, Spectrometers, Detectors And Associated Equipment
Issue number1-3

Bibliographical note

Xu981 Times Cited:5 Cited References Count:6

King's Authors


A novel tissue imaging system has been developed utilising a cooled scientific grade charge coupled device (CCD) to detect the low energy X-ray emissions and beta particle emissions from a variety of isotopes commonly used in tissue autoradiography. Results are presented which illustrate the systems potential for faster and more accurate imaging of tissue samples than is conventionally achieved using film emulsion autoradiography. With position resolution approaching 20 mu m and intrinsic sensitivity approaching 100%, the CCD system also surpasses the performance of current digital autoradiography technology. Because of the frame-by-frame composite way in which images are constructed, the system displays excellent linearity over a large dynamic range. Operation of the CCD in the inverted mode at temperatures up to 35 degrees C has been investigated, with promising results.

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