A Clinical & Experimental Obstetrics and Gynecology survey on ursodeoxycholic treatment of intrahepatic cholestasis of pregnancy: Scholars' opinion

Caroline Ovadia, Ugo Indraccolo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The current paper reports a survey on intrahepatic cholestasis of pregnancy (ICP), concerning obstetric outcomes and treatment of the disease. The survey assessed the opinions of contributors on ursodeoxycholic acid (UDCA) therapy and ICP care. It was administered online on behalf of the editorial office of Clinical & Experimental Obstetrics and Gynecology. Ten questions were provided to the scholars, fellows and peers. Nine questions of the survey allowed closed answers, while the tenth question was open. Semantic Brand Score (https://semanticbrandscore.com/) was used to conduct the survey and to extract the key concepts on ICP. Despite the unclear roles of ursodeoxycholic acid in ICP, respondents believed that reducing the bile acid using ursodeoxycholic acid was beneficial to prevent adverse pregnancy outcomes. The three key-concepts frequently reported by respondents in the optional text responses were (1) disease severity, (2) need for research, and (3) management. In conclusion, respondents demonstrated a marked disparity in their understanding and use of ursodeoxycholic acid in ICP, highlighting the importance of urgent update of international guidelines, in the light of recent publications.

Original languageEnglish
Pages (from-to)1300-1303
Number of pages4
JournalClinical and Experimental Obstetrics and Gynecology
Volume48
Issue number6
DOIs
Publication statusPublished - 15 Dec 2021

Keywords

  • Intrahepatic cholestasis of pregnancy
  • Opinion
  • Outcome
  • Survey
  • Treatment
  • Ursodeoxycholic acid

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