King's College London

Research portal

A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors

Research output: Contribution to journalArticle

Standard

A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors. / Sahara, Setsuko; Kodama, Takashi ; Stevens, Charles F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 26, 16.06.2020, p. 15221-15229.

Research output: Contribution to journalArticle

Harvard

Sahara, S, Kodama, T & Stevens, CF 2020, 'A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 26, pp. 15221-15229. https://doi.org/10.1073/pnas.1916665117

APA

Sahara, S., Kodama, T., & Stevens, C. F. (2020). A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors. Proceedings of the National Academy of Sciences of the United States of America, 117(26), 15221-15229. https://doi.org/10.1073/pnas.1916665117

Vancouver

Sahara S, Kodama T, Stevens CF. A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors. Proceedings of the National Academy of Sciences of the United States of America. 2020 Jun 16;117(26):15221-15229. https://doi.org/10.1073/pnas.1916665117

Author

Sahara, Setsuko ; Kodama, Takashi ; Stevens, Charles F. / A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors. In: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Vol. 117, No. 26. pp. 15221-15229.

Bibtex Download

@article{f6adaf373e044ce393757042d5e238dd,
title = "A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors",
abstract = "The balance between proliferation and differentiation of stem cells and progenitors determines the size of an adult brain region. While the molecular mechanisms regulating proliferation and differentiation of cortical progenitors have been intensively studied, an analysis of the kinetics of progenitor choice between self-renewal and differentiation in vivo is, due to the technical difficulties, still unknown. Here we established a descriptive mathematical model to estimate the probability of self-renewal or differentiation of cortical progenitor behaviors in vivo, a variable we have termed the expansion coefficient. We have applied the model, one which depends only on experimentally measured parameters, to the developing mouse cortex where the expansive neuroepithelial cells and neurogenic radial glial progenitors are coexisting. Surprisingly, we found that the expansion coefficients of both neuroepithelium cells and radial glial progenitors follow the same developmental trajectory during cortical development, suggesting a common rule governing self-renewal/differentiation behaviors in mouse cortical progenitor differentiation.",
keywords = "cortical development, expansion coefficient, neuroepithelial cells, radial glia progenitors",
author = "Setsuko Sahara and Takashi Kodama and Stevens, {Charles F.}",
year = "2020",
month = "6",
day = "16",
doi = "10.1073/pnas.1916665117",
language = "English",
volume = "117",
pages = "15221--15229",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Acad Sciences",
number = "26",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - A Common Rule Governing Differentiation Kinetics of Mouse Cortical Progenitors

AU - Sahara, Setsuko

AU - Kodama, Takashi

AU - Stevens, Charles F.

PY - 2020/6/16

Y1 - 2020/6/16

N2 - The balance between proliferation and differentiation of stem cells and progenitors determines the size of an adult brain region. While the molecular mechanisms regulating proliferation and differentiation of cortical progenitors have been intensively studied, an analysis of the kinetics of progenitor choice between self-renewal and differentiation in vivo is, due to the technical difficulties, still unknown. Here we established a descriptive mathematical model to estimate the probability of self-renewal or differentiation of cortical progenitor behaviors in vivo, a variable we have termed the expansion coefficient. We have applied the model, one which depends only on experimentally measured parameters, to the developing mouse cortex where the expansive neuroepithelial cells and neurogenic radial glial progenitors are coexisting. Surprisingly, we found that the expansion coefficients of both neuroepithelium cells and radial glial progenitors follow the same developmental trajectory during cortical development, suggesting a common rule governing self-renewal/differentiation behaviors in mouse cortical progenitor differentiation.

AB - The balance between proliferation and differentiation of stem cells and progenitors determines the size of an adult brain region. While the molecular mechanisms regulating proliferation and differentiation of cortical progenitors have been intensively studied, an analysis of the kinetics of progenitor choice between self-renewal and differentiation in vivo is, due to the technical difficulties, still unknown. Here we established a descriptive mathematical model to estimate the probability of self-renewal or differentiation of cortical progenitor behaviors in vivo, a variable we have termed the expansion coefficient. We have applied the model, one which depends only on experimentally measured parameters, to the developing mouse cortex where the expansive neuroepithelial cells and neurogenic radial glial progenitors are coexisting. Surprisingly, we found that the expansion coefficients of both neuroepithelium cells and radial glial progenitors follow the same developmental trajectory during cortical development, suggesting a common rule governing self-renewal/differentiation behaviors in mouse cortical progenitor differentiation.

KW - cortical development

KW - expansion coefficient

KW - neuroepithelial cells

KW - radial glia progenitors

UR - http://www.scopus.com/inward/record.url?scp=85087468853&partnerID=8YFLogxK

U2 - 10.1073/pnas.1916665117

DO - 10.1073/pnas.1916665117

M3 - Article

VL - 117

SP - 15221

EP - 15229

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 26

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454