A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy

Antonios P. Antoniadis; Jonathan M. Behar; Ben Sieniewicz; Justin Gould; Steven Niederer; Christopher A. Rinaldi

doi:10.1080/17434440.2017.1369404

A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy

Antonios P. Antoniadis^*, Jonathan M. Behar, Ben Sieniewicz, Justin Gould, Steven Niederer, Christopher A. Rinaldi

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Introduction: Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas covered: This review article concisely summarizes the main technical characteristics of the quadripolar LV leads either currently available in the market today or under final stages of development. Focus is given in recent advancements in the area and challenging aspects and controversies, future implications as well as opportunities for further development. Expert commentary: Quadripolar LV pacing leads have now become the standard of care in CRT. Currently a multitude of lead options is available to the clinician. The selection process of the most appropriate lead is far from the ‘one size fits all’ concept. Further development of quadripolar LV leads is currently ongoing and it is anticipated to contribute towards the release of more technologically advantageous leads which will enable the delivery of optimal CRT therapy with the lowest rate of complications.

Original language	English
Pages (from-to)	697-706
Number of pages	10
Journal	Expert Review Of Medical Devices
Volume	14
Issue number	9
DOIs	https://doi.org/10.1080/17434440.2017.1369404
Publication status	Published - 2 Sept 2017

Keywords

biventricular pacing
cardiac resynchronization therapy
heart failure
multisite pacing
Quadripolar left ventricular leads

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10.1080/17434440.2017.1369404

Cite this

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title = "A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy",

abstract = "Introduction: Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas covered: This review article concisely summarizes the main technical characteristics of the quadripolar LV leads either currently available in the market today or under final stages of development. Focus is given in recent advancements in the area and challenging aspects and controversies, future implications as well as opportunities for further development. Expert commentary: Quadripolar LV pacing leads have now become the standard of care in CRT. Currently a multitude of lead options is available to the clinician. The selection process of the most appropriate lead is far from the {\textquoteleft}one size fits all{\textquoteright} concept. Further development of quadripolar LV leads is currently ongoing and it is anticipated to contribute towards the release of more technologically advantageous leads which will enable the delivery of optimal CRT therapy with the lowest rate of complications.",

keywords = "biventricular pacing, cardiac resynchronization therapy, heart failure, multisite pacing, Quadripolar left ventricular leads",

author = "Antoniadis, {Antonios P.} and Behar, {Jonathan M.} and Ben Sieniewicz and Justin Gould and Steven Niederer and Rinaldi, {Christopher A.}",

note = "Funding Information: CA Rinaldi has received research funding and Honoraria from Abbott, Medtronic, Boston Scientific and Livanova. JM Behar has received speaker fees for Abbott. J Gould has received a fellowship sponsored by SJM/Abbott. S Niederer discloses the following grants UK Engineering and Physical Sciences Research Council (EP/P01268X/1), Boston Scientific and British Heart Foundation (PG/15/91/31812). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",

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AU - Behar, Jonathan M.

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AU - Gould, Justin

AU - Niederer, Steven

AU - Rinaldi, Christopher A.

N1 - Funding Information: CA Rinaldi has received research funding and Honoraria from Abbott, Medtronic, Boston Scientific and Livanova. JM Behar has received speaker fees for Abbott. J Gould has received a fellowship sponsored by SJM/Abbott. S Niederer discloses the following grants UK Engineering and Physical Sciences Research Council (EP/P01268X/1), Boston Scientific and British Heart Foundation (PG/15/91/31812). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © 2017 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2017/9/2

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N2 - Introduction: Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas covered: This review article concisely summarizes the main technical characteristics of the quadripolar LV leads either currently available in the market today or under final stages of development. Focus is given in recent advancements in the area and challenging aspects and controversies, future implications as well as opportunities for further development. Expert commentary: Quadripolar LV pacing leads have now become the standard of care in CRT. Currently a multitude of lead options is available to the clinician. The selection process of the most appropriate lead is far from the ‘one size fits all’ concept. Further development of quadripolar LV leads is currently ongoing and it is anticipated to contribute towards the release of more technologically advantageous leads which will enable the delivery of optimal CRT therapy with the lowest rate of complications.

AB - Introduction: Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas covered: This review article concisely summarizes the main technical characteristics of the quadripolar LV leads either currently available in the market today or under final stages of development. Focus is given in recent advancements in the area and challenging aspects and controversies, future implications as well as opportunities for further development. Expert commentary: Quadripolar LV pacing leads have now become the standard of care in CRT. Currently a multitude of lead options is available to the clinician. The selection process of the most appropriate lead is far from the ‘one size fits all’ concept. Further development of quadripolar LV leads is currently ongoing and it is anticipated to contribute towards the release of more technologically advantageous leads which will enable the delivery of optimal CRT therapy with the lowest rate of complications.

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KW - cardiac resynchronization therapy

KW - heart failure

KW - multisite pacing

KW - Quadripolar left ventricular leads

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ER -

A comparison of the different features of quadripolar left ventricular pacing leads to deliver cardiac resynchronization therapy

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