A condensed view of chromatin during T cell development

TY - JOUR

T1 - A condensed view of chromatin during T cell development

AU - Wood, Andrew J.

AU - Bickmore, Wendy A.

PY - 2011/1/19

Y1 - 2011/1/19

N2 - In cell-mediated immunity, specific T cell subsets proliferate in response to cytokines. But the mechanisms that limit clonal expansion to only those T cells that have recognised foreign antigen via their T cell receptor (TCR) are incompletely understood. In this issue of The EMBO Journal, Rawlings et at (2011) identify one such mechanism that acts, unexpectedly, through chromatin compaction and involves a subunit of condensin-a complex better known for restructuring chromosomes in preparation for cell division.

AB - In cell-mediated immunity, specific T cell subsets proliferate in response to cytokines. But the mechanisms that limit clonal expansion to only those T cells that have recognised foreign antigen via their T cell receptor (TCR) are incompletely understood. In this issue of The EMBO Journal, Rawlings et at (2011) identify one such mechanism that acts, unexpectedly, through chromatin compaction and involves a subunit of condensin-a complex better known for restructuring chromosomes in preparation for cell division.

U2 - 10.1038/emboj.2010.340

DO - 10.1038/emboj.2010.340

M3 - Article

VL - 30

SP - 235

EP - 236

JO - EMBO Journal

JF - EMBO Journal

IS - 2

ER -