A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity

Matteo Bergami, Giacomo Masserdotti, Silvio G Temprana, Elisa Motori, Therese M Eriksson, Jana Göbel, Sun Min Yang, Karl-Klaus Conzelmann, Alejandro F Schinder, Magdalena Götz, Benedikt Berninger

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)

Abstract

Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2–6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
Original languageEnglish
Pages (from-to)710-717
JournalNeuron
Volume85
Issue number4
Early online date5 Feb 2015
DOIs
Publication statusPublished - 18 Feb 2015

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