A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes

Gwyn T. Williams, Mirna Mourtada-Maarabouni, Farzin Farzaneh

    Research output: Contribution to journalConference paper

    92 Citations (Scopus)

    Abstract

    Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5'-TOP (5'-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway. GASS was identified by functional expression cloning and is necessary and sufficient for normal growth arrest in both leukaemic and untransformed human T-lymphocytes. GAS5 is also required for the inhibitory effects of rapamycin and its analogues on T-cells. The striking functional effects of GAS5 may be mediated through the snoRNAs (small nucleolar RNAs) encoded in its introns and/or through the unusual folding of the mRNA itself, which sequesters, and therefore inhibits, the glucocorticoid receptor.
    Original languageEnglish
    Pages (from-to)482 - 486
    Number of pages5
    JournalBiochemical Society Transactions
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - Apr 2011
    EventFocused Meeting of the Biochemical-Society on mTOR Signalling in Health and Disease - London, ENGLAND
    Duration: 11 Nov 201012 Nov 2010

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