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A Cross-Sectional Study of Sleep and Depression in a Rheumatoid Arthritis Population

Research output: Contribution to journalArticle

Original languageEnglish
JournalClinical rheumatology
Accepted/In press6 Sep 2020

King's Authors


Objectives. To assess the prevalence of impaired sleep quality and depression in a rheumatoid arthritis population and determine their correlation with Disease Activity Score (DAS) and its components.
Methods. In this single centre observational cross-sectional study, data was collected by the assessing clinician for DAS28, age and gender in various treatment groups according to use of csDAMRDs, biologics and long-term steroids. Presence of impaired sleep quality and depression was assessed by the Pittsburgh Sleep Quality Index (PSQI) and Public Health Questionnaire 9 (PHQ 9). Correlation for DAS and its components with the outcomes was determined by Pearsons correlation coefficient. Multivariate analysis was performed by logistic regression.
Results. 200 patients were included. The prevalence across all subgroups of poor sleep quality and depression were 86.5% and 30% respectively, with a correlation coefficient of 0.69 between the two and poor sleep quality amongst all RA patients with comorbid depression. Multivariate analysis found only subjective DAS components, tender joint count (TJC) and patient global health visual analogue score (VAS) to significantly correlate with both outcomes. Age inversely correlated with depression. Long term steroid use was associated with poorer sleep quality, but there was no significant effect of csDMARDs or biologics. There was no significant difference in prevalence of depression amongst treatment subgroups.
Conclusion. Poor sleep quality and to a lesser extent, depression are prevalent in the general rheumatoid arthritis population. Patients would benefit from clinicians measuring these outcomes routinely as they constitute a significant non-inflammatory burden of living with rheumatoid disease.

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