A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

Kogularamanan  Suntharalingam; Anna Łczkowska; Mona A. Furrer; Yilei Wu; Marina K. Kuimova; Bruno Therrien; Andrew J P White; Ramon Vilar

doi:10.1002/chem.201202990

A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

Kogularamanan Suntharalingam^*, Anna Łczkowska, Mona A. Furrer, Yilei Wu, Marina K. Kuimova, Bruno Therrien, Andrew J P White, Ramon Vilar

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.

Original language	English
Pages (from-to)	16277-16282
Number of pages	6
Journal	Chemistry (Weinheim an der Bergstrasse, Germany)
Volume	18
Issue number	51
DOIs	https://doi.org/10.1002/chem.201202990
Publication status	Published - 14 Dec 2012

Keywords

G-quadruplexes
host-guest interactions
molecular cages
optical imaging
platinum

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10.1002/chem.201202990

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abstract = "Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.",

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AU - Suntharalingam, Kogularamanan

AU - Łczkowska, Anna

AU - Furrer, Mona A.

AU - Wu, Yilei

AU - Kuimova, Marina K.

AU - Therrien, Bruno

AU - White, Andrew J P

AU - Vilar, Ramon

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AB - Hits the spot: A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo-cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.

KW - G-quadruplexes

KW - host-guest interactions

KW - molecular cages

KW - optical imaging

KW - platinum

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JO - Chemistry (Weinheim an der Bergstrasse, Germany)

JF - Chemistry (Weinheim an der Bergstrasse, Germany)

IS - 51

ER -

A cyclometallated platinum complex as a selective optical switch for quadruplex DNA

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Keywords

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