A dedicated neonatal brain imaging system

TY - JOUR

T1 - A dedicated neonatal brain imaging system

AU - Hughes, Emer J

AU - Winchman, Tobias

AU - Padormo, Francesco

AU - Teixeira, Rui

AU - Wurie, Julia

AU - Sharma, Maryanne

AU - Fox, Matthew

AU - Hutter, Jana

AU - Cordero-Grande, Lucilio

AU - Price, Anthony N

AU - Allsop, Joanna

AU - Bueno-Conde, Jose

AU - Tusor, Nora

AU - Arichi, Tomoki

AU - Edwards, A D

AU - Rutherford, Mary A

AU - Counsell, Serena J

AU - Hajnal, Joseph V

N1 - © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

PY - 2017/8

Y1 - 2017/8

N2 - PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.

AB - PURPOSE: The goal of the Developing Human Connectome Project is to acquire MRI in 1000 neonates to create a dynamic map of human brain connectivity during early development. High-quality imaging in this cohort without sedation presents a number of technical and practical challenges.METHODS: We designed a neonatal brain imaging system (NBIS) consisting of a dedicated 32-channel receive array coil and a positioning device that allows placement of the infant's head deep into the coil for maximum signal-to-noise ratio (SNR). Disturbance to the infant was minimized by using an MRI-compatible trolley to prepare and transport the infant and by employing a slow ramp-up and continuation of gradient noise during scanning. Scan repeats were minimized by using a restart capability for diffusion MRI and retrospective motion correction. We measured the 1) SNR gain, 2) number of infants with a completed scan protocol, and 3) number of anatomical images with no motion artifact using NBIS compared with using an adult 32-channel head coil.RESULTS: The NBIS has 2.4 times the SNR of the adult coil and 90% protocol completion rate.CONCLUSION: The NBIS allows advanced neonatal brain imaging techniques to be employed in neonatal brain imaging with high protocol completion rates.

U2 - 10.1002/mrm.26462

DO - 10.1002/mrm.26462

M3 - Article

C2 - 27643791

SN - 1522-2594

VL - 78

SP - 794

EP - 804

JO - Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

JF - Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine

IS - 2

ER -