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A discordance between the human muscle NCAM sequence and those seen in other NCAM cDNAs

Research output: Contribution to journalArticle

R J Rossell, Afshan Malik, W Helfrich, J T Kemshead, K Patel

Original languageEnglish
Article numberN/A
Pages (from-to)95-96
Number of pages2
JournalBiochimica et Biophysica Acta
Volume1130
Issue number1
Publication statusPublished - 28 Feb 1992

King's Authors

Abstract

A cDNA clone, designated NC7, has been isolated from human foetal kidney that partially codes for the 140 kDa isoform of human NCAM. This clone contains a 6 bp insert that is not present in the human muscle cDNA clone λ4.4. This same sequence has also been found in both a cDNA clone obtained from a human Small Cell Lung Carcinoma (SCLC) line and in human genomic DNA. Furthermore, an equivalent sequence to the 6 bp region identified in the above samples is present in mouse, rat and chicken NCAM. The 6 bp insertion does not lie at a predicted intron/exon boundary as extrapolated by homology studies with the chicken and, therefore, the mechanism by which the sequence is deleted from the human muscle clone λ4.4 remains unclear.

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