A distance-dependent distribution of presynaptic boutons tunes frequency-dependent dendritic integration

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Abstract

How presynaptic inputs and neurotransmitter release dynamics are distributed along a dendritic tree is not well established. Here, we show that presynaptic boutons that form onto basal dendrites of CA1 pyramidal neurons display a decrease in active zone (AZ) size with distance from the soma, resulting in a distance-dependent increase in short-term facilitation. Our findings suggest that the spatial distribution of short-term facilitation serves to compensate for the electrotonic attenuation of subthreshold distal inputs during repeated stimulation and fine-tunes the preferred input frequency of dendritic domains.
Original languageEnglish
Pages (from-to)275-282
JournalNeuron
Volume99
Issue number2
Early online date5 Jul 2018
DOIs
Publication statusPublished - 25 Jul 2018

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