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A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution

Research output: Contribution to journalArticle

Kate Lauder, Domiziana Masci, Anita Toscani, Aya Al Mekdad, Gary W. Black, Nicola L. Brown, Nicholas J. Turner, Renzo Luisi, Daniele Castagnolo

Original languageEnglish
Pages (from-to)8982-8986
Number of pages5
JournalORGANIC AND BIOMOLECULAR CHEMISTRY
Volume17
Issue number40
Early online date25 Sep 2019
DOIs
Accepted/In press25 Sep 2019
E-pub ahead of print25 Sep 2019

King's Authors

Abstract

A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.

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