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A framework for advancing our understanding of cancer-associated fibroblasts

Research output: Contribution to journalReview articlepeer-review

Erik Sahai, Igor Astsaturov, Edna Cukierman, David G DeNardo, Mikala Egeblad, Ronald M Evans, Douglas Fearon, Florian R Greten, Sunil R Hingorani, Tony Hunter, Richard O Hynes, Rakesh K Jain, Tobias Janowitz, Claus Jorgensen, Alec C Kimmelman, Mikhail G Kolonin, Robert G Maki, R Scott Powers, Ellen Puré, Daniel C Ramirez & 9 more Ruth Scherz-Shouval, Mara H Sherman, Sheila Stewart, Thea D Tlsty, David A Tuveson, Fiona M Watt, Valerie Weaver, Ashani T Weeraratna, Zena Werb

Original languageEnglish
Pages (from-to)174-186
Number of pages13
Issue number3
Early online date24 Jan 2020
E-pub ahead of print24 Jan 2020
Published1 Mar 2020

King's Authors


Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating leukocytes. As such, they are a potential target for optimizing therapeutic strategies against cancer. However, many challenges are present in ongoing attempts to modulate CAFs for therapeutic benefit. These include limitations in our understanding of the origin of CAFs and heterogeneity in CAF function, with it being desirable to retain some antitumorigenic functions. On the basis of a meeting of experts in the field of CAF biology, we summarize in this Consensus Statement our current knowledge and present a framework for advancing our understanding of this critical cell type within the tumour microenvironment.

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