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A framework for memory performance prediction from brain volume in preterm-born adolescents

Research output: Contribution to journalArticle

Hassna Irzan, Helen O'Reilly, Sebastien Ourselin, Neil Marlow, Andrew Melbourne

Original languageEnglish
Pages (from-to)400-403
Number of pages4
JournalInternational Symposium on Biomedical Imaging (ISBI)
Publication statusPublished - 1 Apr 2019
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: 8 Apr 201911 Apr 2019

King's Authors


With advances in medical care, higher numbers of extremely preterm-born babies are now surviving, however the rate of neurodevelopmental and neurological complications has not improved at the same rate and the relative rate of disabilities and health problems is increasing, with associated high costs for health care systems and education. Understanding brain development after early birth is of great importance to be able to make informed decisions. Many studies have associated different areas of the preterm brain with poor cognitive performance, however it is less clear whether these associations persist into adult life. In this study, we investigate how well cortical volumes describe memory performance in 133 19 year-old adolescents, 61% of whom were born extremely preterm. We employ LASSO to identify brain regions that better explain memory performance. The brain regions identified by LASSO explained 27% and 32% of the variance in the visual working memory scores and the visual short term memory respectively. Furthermore, the correlation between the predicted scores and validation scores is statistically significant and it is 58% for the visual working memory task and 56% for the visual short term memory task.

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