A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

J Hampe; A Franke; P Rosenstiel; A Till; M Teuber; K Huse; M Albrecht; G Mayr; F M De La Vega; J Briggs; S Gunther; N J Prescott; C M Onnie; R Hasler; B Sipos; U R Folsch; T Lengauer; M Platzer; C G Mathew; M Krawczak; S Schreiber

doi:10.1038/ng1954

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

J Hampe, A Franke, P Rosenstiel, A Till, M Teuber, K Huse, M Albrecht, G Mayr, F M De La Vega, J Briggs, S Gunther, N J Prescott, C M Onnie, R Hasler, B Sipos, U R Folsch, T Lengauer, M Platzer, C G Mathew, M KrawczakS Schreiber

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Abstract

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease

Original language	English
Pages (from-to)	207 - 211
Number of pages	5
Journal	Nature Genetics
Volume	39
Issue number	2
DOIs	https://doi.org/10.1038/ng1954
Publication status	Published - Feb 2007

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Hampe, J., Franke, A., Rosenstiel, P., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., De La Vega, F. M., Briggs, J., Gunther, S., Prescott, N. J., Onnie, C. M., Hasler, R., Sipos, B., Folsch, U. R., Lengauer, T., Platzer, M., Mathew, C. G., ... Schreiber, S. (2007). A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nature Genetics, 39(2), 207 - 211. https://doi.org/10.1038/ng1954

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title = "A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1",

abstract = "We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease",

author = "J Hampe and A Franke and P Rosenstiel and A Till and M Teuber and K Huse and M Albrecht and G Mayr and {De La Vega}, {F M} and J Briggs and S Gunther and Prescott, {N J} and Onnie, {C M} and R Hasler and B Sipos and Folsch, {U R} and T Lengauer and M Platzer and Mathew, {C G} and M Krawczak and S Schreiber",

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doi = "10.1038/ng1954",

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Hampe, J, Franke, A, Rosenstiel, P, Till, A, Teuber, M, Huse, K, Albrecht, M, Mayr, G, De La Vega, FM, Briggs, J, Gunther, S, Prescott, NJ , Onnie, CM, Hasler, R, Sipos, B, Folsch, UR, Lengauer, T, Platzer, M, Mathew, CG, Krawczak, M & Schreiber, S 2007, 'A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1', Nature Genetics, vol. 39, no. 2, pp. 207 - 211. https://doi.org/10.1038/ng1954

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T1 - A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

AU - Hampe, J

AU - Franke, A

AU - Rosenstiel, P

AU - Till, A

AU - Teuber, M

AU - Huse, K

AU - Albrecht, M

AU - Mayr, G

AU - De La Vega, F M

AU - Briggs, J

AU - Gunther, S

AU - Prescott, N J

AU - Onnie, C M

AU - Hasler, R

AU - Sipos, B

AU - Folsch, U R

AU - Lengauer, T

AU - Platzer, M

AU - Mathew, C G

AU - Krawczak, M

AU - Schreiber, S

PY - 2007/2

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N2 - We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease

AB - We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease

U2 - 10.1038/ng1954

DO - 10.1038/ng1954

M3 - Article

SN - 1546-1718

VL - 39

SP - 207

EP - 211

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Abstract

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