A Genome-Wide Association Study Identifies an Osteoarthritis Susceptibility Locus on Chromosome 7q22

Hanneke J. M. Kerkhof, Rik J. Lories, Ingrid Meulenbelt, Ingileif Jonsdottir, Ana M. Valdes, Pascal Arp, Thorvaldur Ingvarsson, Mila Jhamai, Helgi Jonsson, Lisette Stolk, Gudmar Thorleifsson, Guangju Zhai, Feng Zhang, Yanyan Zhu, Ruud van der Breggen, Andrew Carr, Michael Doherty, Sally Doherty, David T. Felson, Antonio GonzalezBjarni V. Halldorsson, Deborah J. Hart, Valdimar B. Hauksson, Albert Hofman, John P. A. Ioannidis, Margreet Kloppenburg, Nancy E. Lane, John Loughlin, Frank P. Luyten, Michael C. Nevitt, Neeta Parimi, Huibert A. P. Pols, Fernando Rivadeneira, Eline P. Slagboom, Unnur Styrkarsdottir, Aspasia Tsezou, Tom van de Putte, Joseph Zmuda, Tim D. Spector, Kari Stefansson, Andre G. Uitterlinden, Joyce B. J. van Meurs

Research output: Contribution to journalArticlepeer-review

179 Citations (Scopus)

Abstract

Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were analyzed in 14,938 OA cases and similar to 39,000 controls. Meta-analyses were performed using the program Comprehensive Meta-analysis, with P values
Original languageEnglish
Pages (from-to)499 - 510
Number of pages12
JournalArthritis & Rheumatism
Volume62
Issue number2
DOIs
Publication statusPublished - Feb 2010

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