Abstract
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene-environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors (P = 3.98x10(-8)). We followed up the association in further genotyped monozygotic twins (N = 1,261), which showed a moderate association for the variant (P = 0.200, same direction of an effect). In addition, we report a new association on the level of apolipoprotein A-II (P = 4.03x10(-8)).
Original language | English |
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Pages (from-to) | 691-699 |
Number of pages | 9 |
Journal | TWIN RESEARCH AND HUMAN GENETICS |
Volume | 15 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2012 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein A-II
- Cholesterol, HDL
- Female
- GTPase-Activating Proteins
- Gene-Environment Interaction
- Genetic Loci
- Genome-Wide Association Study
- Humans
- Introns
- Middle Aged
- Polymorphism, Single Nucleotide
- Twins, Monozygotic