A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

P Asherson; K Zhou; R J L Anney; B Franke; J Buitelaar; R Ebstein; M Gill; M Altink; R Arnold; F Boer; K Brookes; C Buschgens; L Butler; D Cambell; W Chen; H Christiansen; L Feldman; K Fleischman; E Fliers; R Howe-Forbes; A Goldfarb; A Heise; I Gabrieels; L Johansson; I Lubetzki; R Marco; S Medad; R Minderaa; F Mulas; U Mueller; A Mulligan; B Neale; F Rijsdijk; K Rabin; N Rommelse; V Sethna; J Sorohan; H Uebel; L Psychogiou; A Weeks; R Barrett; X Xu; T Banaschewski; E Sonuga-Barke; J Eisenberg; I Manor; A Miranda; R D Oades; H Roeyers; A Rothenberger; J Sergeant; H C Steinhausen; E Taylor; M Thompson; S V Faraone

doi:10.1038/sj.mp.4002140

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

P Asherson, K Zhou, R J L Anney, B Franke, J Buitelaar, R Ebstein, M Gill, M Altink, R Arnold, F Boer, K Brookes, C Buschgens, L Butler, D Cambell, W Chen, H Christiansen, L Feldman, K Fleischman, E Fliers, R Howe-ForbesA Goldfarb, A Heise, I Gabrieels, L Johansson, I Lubetzki, R Marco, S Medad, R Minderaa, F Mulas, U Mueller, A Mulligan, B Neale, F Rijsdijk, K Rabin, N Rommelse, V Sethna, J Sorohan, H Uebel, L Psychogiou, A Weeks, R Barrett, X Xu, T Banaschewski, E Sonuga-Barke, J Eisenberg, I Manor, A Miranda, R D Oades, H Roeyers, A Rothenberger, J Sergeant, H C Steinhausen, E Taylor, M Thompson, S V Faraone

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Abstract

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci

Original language	English
Pages (from-to)	514 - 521
Number of pages	8
Journal	Molecular Psychiatry
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/sj.mp.4002140
Publication status	Published - 10 May 2008

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Asherson, P., Zhou, K., Anney, R. J. L., Franke, B., Buitelaar, J., Ebstein, R., Gill, M., Altink, M., Arnold, R., Boer, F., Brookes, K., Buschgens, C., Butler, L., Cambell, D., Chen, W., Christiansen, H., Feldman, L., Fleischman, K., Fliers, E., ... Faraone, S. V. (2008). A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Molecular Psychiatry, 13(5), 514 - 521. https://doi.org/10.1038/sj.mp.4002140

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title = "A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16",

abstract = "As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci",

author = "P Asherson and K Zhou and Anney, {R J L} and B Franke and J Buitelaar and R Ebstein and M Gill and M Altink and R Arnold and F Boer and K Brookes and C Buschgens and L Butler and D Cambell and W Chen and H Christiansen and L Feldman and K Fleischman and E Fliers and R Howe-Forbes and A Goldfarb and A Heise and I Gabrieels and L Johansson and I Lubetzki and R Marco and S Medad and R Minderaa and F Mulas and U Mueller and A Mulligan and B Neale and F Rijsdijk and K Rabin and N Rommelse and V Sethna and J Sorohan and H Uebel and L Psychogiou and A Weeks and R Barrett and X Xu and T Banaschewski and E Sonuga-Barke and J Eisenberg and I Manor and A Miranda and Oades, {R D} and H Roeyers and A Rothenberger and J Sergeant and Steinhausen, {H C} and E Taylor and M Thompson and Faraone, {S V}",

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language = "English",

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pages = "514 -- 521",

journal = "Molecular Psychiatry",

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Asherson, P, Zhou, K, Anney, RJL, Franke, B, Buitelaar, J, Ebstein, R, Gill, M, Altink, M, Arnold, R, Boer, F, Brookes, K, Buschgens, C, Butler, L, Cambell, D, Chen, W, Christiansen, H, Feldman, L, Fleischman, K, Fliers, E, Howe-Forbes, R, Goldfarb, A, Heise, A, Gabrieels, I, Johansson, L, Lubetzki, I, Marco, R, Medad, S, Minderaa, R, Mulas, F, Mueller, U, Mulligan, A, Neale, B, Rijsdijk, F, Rabin, K, Rommelse, N, Sethna, V, Sorohan, J, Uebel, H, Psychogiou, L, Weeks, A, Barrett, R, Xu, X, Banaschewski, T, Sonuga-Barke, E, Eisenberg, J, Manor, I, Miranda, A, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Steinhausen, HC, Taylor, E, Thompson, M & Faraone, SV 2008, 'A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16', Molecular Psychiatry, vol. 13, no. 5, pp. 514 - 521. https://doi.org/10.1038/sj.mp.4002140

TY - JOUR

T1 - A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

AU - Asherson, P

AU - Zhou, K

AU - Anney, R J L

AU - Franke, B

AU - Buitelaar, J

AU - Ebstein, R

AU - Gill, M

AU - Altink, M

AU - Arnold, R

AU - Boer, F

AU - Brookes, K

AU - Buschgens, C

AU - Butler, L

AU - Cambell, D

AU - Chen, W

AU - Christiansen, H

AU - Feldman, L

AU - Fleischman, K

AU - Fliers, E

AU - Howe-Forbes, R

AU - Goldfarb, A

AU - Heise, A

AU - Gabrieels, I

AU - Johansson, L

AU - Lubetzki, I

AU - Marco, R

AU - Medad, S

AU - Minderaa, R

AU - Mulas, F

AU - Mueller, U

AU - Mulligan, A

AU - Neale, B

AU - Rijsdijk, F

AU - Rabin, K

AU - Rommelse, N

AU - Sethna, V

AU - Sorohan, J

AU - Uebel, H

AU - Psychogiou, L

AU - Weeks, A

AU - Barrett, R

AU - Xu, X

AU - Banaschewski, T

AU - Sonuga-Barke, E

AU - Eisenberg, J

AU - Manor, I

AU - Miranda, A

AU - Oades, R D

AU - Roeyers, H

AU - Rothenberger, A

AU - Sergeant, J

AU - Steinhausen, H C

AU - Taylor, E

AU - Thompson, M

AU - Faraone, S V

PY - 2008/5/10

Y1 - 2008/5/10

N2 - As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci

AB - As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99cM (log of the odds, LOD= 3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD > 1, similar to 95 cM) and Dutch LOD > 1, similar to 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90cM (LOD = 2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD= 1.45 at 93 cM; German LOD= 0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci

U2 - 10.1038/sj.mp.4002140

DO - 10.1038/sj.mp.4002140

M3 - Article

VL - 13

SP - 514

EP - 521

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 5

ER -

A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

Abstract

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